Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis
Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Joncour, Agnès, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Rondet, Emilie, Peixoto, Christophe, Grassot, Jean-Marie, Picolet, Olivier, Annoot, Denis, Triballeau, Nicolas, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Blanque, Roland, Cottereaux, Celine, Vandervoort, Nele, Christophe, Thierry, Mollat, Patrick, Lamers, Marieke, Auberval, Marielle, Hrvacic, Boska, Ralic, Jovica, Oste, Line, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand
Published in Journal of medicinal chemistry (11.05.2017)
Published in Journal of medicinal chemistry (11.05.2017)
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Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2‑a]pyridine Series of Autotaxin Inhibitors
Joncour, Agnès, Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Peixoto, Christophe, Annoot, Denis, Lepissier, Luce, Heiermann, Jörg, Hengeveld, Willem Jan, Pilzak, Gregor, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Galien, René, David, Christelle, Vandervoort, Nele, Christophe, Thierry, Conrath, Katja, Jans, Mia, Wohlkonig, Alexandre, Soror, Sameh, Steyaert, Jan, Touitou, Robert, Fleury, Damien, Vercheval, Lionel, Mollat, Patrick, Triballeau, Nicolas, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand
Published in Journal of medicinal chemistry (14.09.2017)
Published in Journal of medicinal chemistry (14.09.2017)
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Discovery of GLPG2737, a Potent Type 2 Corrector of CFTR for the Treatment of Cystic Fibrosis in Combination with a Potentiator and a Type 1 Co-corrector
Pizzonero, Mathieu, Akkari, Rhalid, Bock, Xavier, Gosmini, Romain, De Lemos, Elsa, Duthion, Béranger, Newsome, Gregory, Mai, Thi-Thu-Trang, Roques, Virginie, Jary, Hélène, Lefrancois, Jean-Michel, Cherel, Laetitia, Quenehen, Vanessa, Babel, Marielle, Merayo, Nuria, Bienvenu, Natacha, Mammoliti, Oscar, Coti, Ghjuvanni, Palisse, Adeline, Cowart, Marlon, Shrestha, Anurupa, Greszler, Stephen, Van Der Plas, Steven, Jansen, Koen, Claes, Pieter, Jans, Mia, Gees, Maarten, Borgonovi, Monica, De Wilde, Gert, Conrath, Katja
Published in Journal of medicinal chemistry (11.04.2024)
Published in Journal of medicinal chemistry (11.04.2024)
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Correction to Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2‑a]pyridine Series of Autotaxin Inhibitors
Joncour, Agnès, Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Peixoto, Christophe, Annoot, Denis, Lepissier, Luce, Heiermann, Jörg, Hengeveld, Willem Jan, Pilzak, Gregor, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Galien, René, David, Christelle, Vandervoort, Nele, Christophe, Thierry, Conrath, Katja, Jans, Mia, Wohlkonig, Alexandre, Soror, Sameh, Steyaert, Jan, Touitou, Robert, Fleury, Damien, Vercheval, Lionel, Mollat, Patrick, Triballeau, Nicolas, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand
Published in Journal of medicinal chemistry (10.05.2018)
Published in Journal of medicinal chemistry (10.05.2018)
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N-설포닐화 피라졸로[3,4-b]피리딘-6-카복스아미드 및 사용 방법
AKKARI RHALID, BROWN BRIAN S, BOCK XAVIER MARIE, HOUSSEMAN CHRISTOPHER GAETAN, PATEL SACHIN V, JI JIANGUO, DE BLIECK ANN, KYM PHILIP R, SHRESTHA ANURUPA, WANG XUEQING, GFESSER GREGORY A, SWIFT ELIZABETH C, ALVEY LUKE JONATHAN, PALISSE ADELINE MARIE ELISE, NEWSOME GREGORY JOHN ROBERT, PIZZONERO MATHIEU RAFAEL, DESROY NICOLAS, MERAYO NURIA MERAYO, CLAES PIETER ISABELLE ROGER, GOSMINI ROMAIN LUC MARIE, DUTHION BERANGER, MENET CHRISTEL JEANNE MARIE, DE LEMOS ELSA, LEFRANCOIS JEAN MICHEL, MAMMOLITI OSCAR, VAN DER PLAS STEVEN EMIEL, JANSEN KOEN KAREL, COWART MARLON D
Year of Publication 20.07.2018
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Year of Publication 20.07.2018
Patent
Discovery of 2‑[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2‑a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis
Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Joncour, Agnès, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Rondet, Emilie, Peixoto, Christophe, Grassot, Jean-Marie, Picolet, Olivier, Annoot, Denis, Triballeau, Nicolas, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Blanque, Roland, Cottereaux, Celine, Vandervoort, Nele, Christophe, Thierry, Mollat, Patrick, Lamers, Marieke, Auberval, Marielle, Hrvacic, Boska, Ralic, Jovica, Oste, Line, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand
Published in Journal of medicinal chemistry (11.05.2017)
Published in Journal of medicinal chemistry (11.05.2017)
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PYRAZOLOPYRIDINE DERIVATIVES AS INHIBITORS OF PASK
BOCK, Xavier, BEAUMONT, Stéphane, LÓPEZ RAMOS, Miriam, TEMAL-LAÏB, Taoues, COMAS MARTINEZ, Daniel, JONCOUR, Agnès, LABÉGUÈRE, Frédéric
Year of Publication 29.09.2021
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Year of Publication 29.09.2021
Patent