Discovery of 6‑(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl‑1H‑indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia
Genin, Michael J, Bueno, Ana B, Agejas Francisco, Javier, Manninen, Peter R, Bocchinfuso, Wayne P, Montrose-Rafizadeh, Chahrzad, Cannady, Ellen A, Jones, Timothy M, Stille, John R, Raddad, Eyas, Reidy, Charles, Cox, Amy, Michael, M. Dodson, Michael, Laura F
Published in Journal of medicinal chemistry (24.12.2015)
Published in Journal of medicinal chemistry (24.12.2015)
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The Hypolipidemic Natural Product Guggulsterone Is a Promiscuous Steroid Receptor Ligand
Burris, Thomas P, Montrose, Chahrzad, Houck, Keith A, Osborne, Harold E, Bocchinfuso, Wayne P, Yaden, Benjamin C, Cheng, Christine C, Zink, Richard W, Barr, Robert J, Hepler, Christoper D, Krishnan, Venkatesh, Bullock, Heather A, Burris, Lorri L, Galvin, Rachelle J, Bramlett, Kelli, Stayrook, Keith R
Published in Molecular pharmacology (01.03.2005)
Published in Molecular pharmacology (01.03.2005)
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Mammary gland development and tumorigenesis in estrogen receptor knockout mice
Bocchinfuso, W P, Korach, K S
Published in Journal of mammary gland biology and neoplasia (01.10.1997)
Published in Journal of mammary gland biology and neoplasia (01.10.1997)
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LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity
Bonday, Zahid Q., Cortez, Guillermo S., Grogan, Michael J., Antonysamy, Stephen, Weichert, Ken, Bocchinfuso, Wayne P., Li, Fengling, Kennedy, Steven, Li, Binghui, Mader, Mary M., Arrowsmith, Cheryl H., Brown, Peter J., Eram, Mohammad S., Szewczyk, Magdalena M., Barsyte-Lovejoy, Dalia, Vedadi, Masoud, Guccione, Ernesto, Campbell, Robert M.
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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Tamoxifen versus Aromatase Inhibitors for Breast Cancer Prevention
Yue, Wei, Wang, Ji-Ping, Li, Yuebai, Bocchinfuso, Wayne P, Korach, Kenneth S, Devanesan, Prabu D, Rogan, Eleanor, Cavalieri, Ercole, Santen, Richard J
Published in Clinical cancer research (15.01.2005)
Published in Clinical cancer research (15.01.2005)
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HDX reveals unique fragment ligands for the vitamin D receptor
Carson, Matthew W, Zhang, Jun, Chalmers, Michael J, Bocchinfuso, Wayne P, Holifield, Karol D, Masquelin, Thierry, Stites, Ryan E, Stayrook, Keith R, Griffin, Patrick R, Dodge, Jeffery A
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
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Catechol estrogen metabolites and conjugates in mammary tumors and hyperplastic tissue from estrogen receptor-α knock-out (ERKO)/Wnt-1 mice: implications for initiation of mammary tumors
Devanesan, Prabu, Santen, Richard J., Bocchinfuso, Wayne P., Korach, Kenneth S., Rogan, Eleanor G., Cavalieri, Ercole
Published in Carcinogenesis (New York) (01.09.2001)
Published in Carcinogenesis (New York) (01.09.2001)
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Development of an HTS-compatible assay for discovery of RORα modulators using AlphaScreen® technology
Istrate, Monica A, Spicer, Timothy P, Wang, Yan, Bernard, Jerrold A, Helvering, Leah M, Bocchinfuso, Wayne P, Richardson, Timothy I, Zink, Richard, Kumar, Naresh, Montrose-Rafizadeh, Chahrzad, Dodge, Jeffrey, Hodder, Peter, Griffin, Patrick R
Published in Journal of biomolecular screening (01.02.2011)
Published in Journal of biomolecular screening (01.02.2011)
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Journal Article
HDX reveals unique fragment ligands for the vitamin D receptor
Carson, Matthew W., Zhang, Jun, Chalmers, Michael J., Bocchinfuso, Wayne P., Holifield, Karol D., Masquelin, Thierry, Stites, Ryan E., Stayrook, Keith R., Griffin, Patrick R., Dodge, Jeffery A.
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
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Lack of ductal development in the absence of functional estrogen receptor alpha delays mammary tumor formation induced by transgenic expression of ErbB2/neu
Hewitt, Sylvia Curtis, Bocchinfuso, Wayne P, Zhai, Jun, Harrell, Chuck, Koonce, Linwood, Clark, James, Myers, Page, Korach, Kenneth S
Published in Cancer research (Chicago, Ill.) (15.05.2002)
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Published in Cancer research (Chicago, Ill.) (15.05.2002)
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Cyclic AMP-independent activation of CYP3A4 gene expression by forskolin
Dowless, Michele S., Barbee, James L., Borchert, Kristen M., Bocchinfuso, Wayne P., Houck, Keith A.
Published in European journal of pharmacology (04.04.2005)
Published in European journal of pharmacology (04.04.2005)
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Potency of combined estrogenic pesticides
Ramamoorthy, K. (Texas AandM University, College Station, TX.), Wang, F, Chen, I.C, Safe, S, Norris, J.D, McDonnell, D.P, Gaido, K.W, Bocchinfuso, W.P, Korach, K.S
Published in Science (American Association for the Advancement of Science) (17.01.1997)
Published in Science (American Association for the Advancement of Science) (17.01.1997)
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Estrogen Receptor Residues Required for Stereospecific Ligand Recognition and Activation
Bocchinfuso, Wayne P, Korach, Kenneth S
Published in Molecular endocrinology (Baltimore, Md.) (01.05.1997)
Published in Molecular endocrinology (Baltimore, Md.) (01.05.1997)
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Abstract 1259: Preclinical characterization of LY3537982, a novel, highly selective and potent KRAS-G12C inhibitor
Peng, Sheng-Bin, Si, Chong, Zhang, Youyan, Van Horn, Robert D., Lin, Xi, Gong, Xueqian, Huber, Lysiane, Donoho, Gregory, Curtis, Carmen, Strelow, John M., Bocchinfuso, Wayne P., Guo, Deqi, Boulet, Serge L., Barda, David, Manglicmot, Danalyn, Saflor, Melbert-Brian D., Wang, Jing, Xiao, Junpeng, Chalmers, Michael J., Burns, Lee, Linder, Ryan J., Ackermann, Bradley L., Cornwell, Paul D., Zhou, Lian, McCann, Denis, Henry, James
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1 H -indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia
Genin, Michael J., Bueno, Ana B., Agejas Francisco, Javier, Manninen, Peter R., Bocchinfuso, Wayne P., Montrose-Rafizadeh, Chahrzad, Cannady, Ellen A., Jones, Timothy M., Stille, John R., Raddad, Eyas, Reidy, Charles, Cox, Amy, Michael, M. Dodson, Michael, Laura F.
Published in Journal of medicinal chemistry (24.12.2015)
Published in Journal of medicinal chemistry (24.12.2015)
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Journal Article
Estrogenic Activity of a Dieldrin/Toxaphene Mixture in the Mouse Uterus, MCF-7 Human Breast Cancer Cells, and Yeast-Based Estrogen Receptor Assays: No Apparent Synergism
Ramamoorthy, Kavita, Wang, Fan, Chen, I-Chen, Norris, John D., McDonnell, Donald P., Leonard, Linda S., Gaido, Kevin W., Bocchinfuso, Wayne P., Korach, Kenneth S., Safe, Stephen
Published in Endocrinology (Philadelphia) (01.04.1997)
Published in Endocrinology (Philadelphia) (01.04.1997)
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