Potent and selective bivalent inhibitors of BET bromodomains
Waring, Michael J, Chen, Huawei, Rabow, Alfred A, Walker, Graeme, Bobby, Romel, Boiko, Scott, Bradbury, Rob H, Callis, Rowena, Clark, Edwin, Dale, Ian, Daniels, Danette L, Dulak, Austin, Flavell, Liz, Holdgate, Geoff, Jowitt, Thomas A, Kikhney, Alexey, McAlister, Mark, Méndez, Jacqui, Ogg, Derek, Patel, Joe, Petteruti, Philip, Robb, Graeme R, Robers, Matthew B, Saif, Sakina, Stratton, Natalie, Svergun, Dmitri I, Wang, Wenxian, Whittaker, David, Wilson, David M, Yao, Yi
Published in Nature chemical biology (01.12.2016)
Published in Nature chemical biology (01.12.2016)
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Journal Article
Segmental Isotope Labelling of an Individual Bromodomain of a Tandem Domain BRD4 Using Sortase A
Williams, Felix P, Milbradt, Alexander G, Embrey, Kevin J, Bobby, Romel
Published in PloS one (29.04.2016)
Published in PloS one (29.04.2016)
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Journal Article
Bromodomain Interactions with Acetylated Histone 4 Peptides in the BRD4 Tandem Domain: Effects on Domain Dynamics and Internal Flexibility
Wernersson, Sven, Bobby, Romel, Flavell, Liz, Milbradt, Alexander G., Holdgate, Geoffrey A., Embrey, Kevin J., Akke, Mikael
Published in Biochemistry (Easton) (01.11.2022)
Published in Biochemistry (Easton) (01.11.2022)
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Journal Article
NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24
Torres, Felix, Walser, Reto, Kaderli, Janina, Rossi, Emanuele, Bobby, Romel, Packer, Martin J, Sarda, Sunil, Walker, Graeme, Hitchin, James R, Milbradt, Alexander G, Orts, Julien
Published in Journal of medicinal chemistry (14.04.2022)
Published in Journal of medicinal chemistry (14.04.2022)
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Journal Article
Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence
Vo, Uybach, Vajpai, Navratna, Flavell, Liz, Bobby, Romel, Breeze, Alexander L., Embrey, Kevin J., Golovanov, Alexander P.
Published in The Journal of biological chemistry (22.01.2016)
Published in The Journal of biological chemistry (22.01.2016)
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Journal Article
Backbone resonance assignments for the SET domain of the human methyltransferase NSD2
Bobby, Romel, Peciak, Karolina, Milbradt, Alexander G.
Published in Biomolecular NMR assignments (01.10.2016)
Published in Biomolecular NMR assignments (01.10.2016)
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Journal Article
Structure and dynamics of human Nedd4-1 WW3 in complex with the αENaC PY motif
Bobby, Romel, Medini, Karima, Neudecker, Philipp, Lee, Tet Verne, Brimble, Margaret A., McDonald, Fiona J., Lott, J. Shaun, Dingley, Andrew J.
Published in Biochimica et biophysica acta (01.08.2013)
Published in Biochimica et biophysica acta (01.08.2013)
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Journal Article
Structure and dynamics of human Nedd4-1 WW3 in complex with the I-ENaC PY motif
Bobby, Romel, Medini, Karima, Neudecker, Philipp, Lee, Tet, Brimble, Margaret, McDonald, Fiona, Lott, J, Dingley, Andrew
Published in Biochimica et biophysica acta. Proteins and proteomics (01.08.2013)
Published in Biochimica et biophysica acta. Proteins and proteomics (01.08.2013)
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Journal Article
Functional implications of large backbone amplitude motions of the glycoprotein 130‐binding epitope of interleukin‐6
Bobby, Romel, Robustelli, Paul, Kralicek, Andrew V., Mobli, Mehdi, King, Glenn F., Grötzinger, Joachim, Dingley, Andrew J.
Published in The FEBS journal (01.05.2014)
Published in The FEBS journal (01.05.2014)
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Journal Article