Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
Hubbard, Basil P., Gomes, Ana P., Dai, Han, Li, Jun, Case, April W., Considine, Thomas, Riera, Thomas V., Lee, Jessica E., Yen E, Sook, Lamming, Dudley W., Pentelute, Bradley L., Schuman, Eli R., Stevens, Linda A., Ling, Alvin J. Y., Armour, Sean M., Michan, Shaday, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Blum, Charles A., Disch, Jeremy S., Ng, Pui Yee, Howitz, Konrad T., Rolo, Anabela P., Hamuro, Yoshitomo, Moss, Joel, Perni, Robert B., Ellis, James L., Vlasuk, George P., Sinclair, David A.
Published in Science (American Association for the Advancement of Science) (08.03.2013)
Published in Science (American Association for the Advancement of Science) (08.03.2013)
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Journal Article
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
Szallasi, Arpad, Cortright, Daniel N, Blum, Charles A, Eid, Samer R
Published in Nature reviews. Drug discovery (01.05.2007)
Published in Nature reviews. Drug discovery (01.05.2007)
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Journal Article
Discovery of Thieno[3,2‑d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3
Disch, Jeremy S, Evindar, Ghotas, Chiu, Cynthia H, Blum, Charles A, Dai, Han, Jin, Lei, Schuman, Eli, Lind, Kenneth E, Belyanskaya, Svetlana L, Deng, Jianghe, Coppo, Frank, Aquilani, Leah, Graybill, Todd L, Cuozzo, John W, Lavu, Siva, Mao, Cheney, Vlasuk, George P, Perni, Robert B
Published in Journal of medicinal chemistry (09.05.2013)
Published in Journal of medicinal chemistry (09.05.2013)
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Journal Article
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
Dai, Han, Case, April W., Riera, Thomas V., Considine, Thomas, Lee, Jessica E., Hamuro, Yoshitomo, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Pietrak, Beth, Schwartz, Benjamin, Blum, Charles A., Disch, Jeremy S., Caldwell, Richard, Szczepankiewicz, Bruce, Oalmann, Christopher, Yee Ng, Pui, White, Brian H., Casaubon, Rebecca, Narayan, Radha, Koppetsch, Karsten, Bourbonais, Francis, Wu, Bo, Wang, Junfeng, Qian, Dongming, Jiang, Fan, Mao, Cheney, Wang, Minghui, Hu, Erding, Wu, Joe C., Perni, Robert B., Vlasuk, George P., Ellis, James L.
Published in Nature communications (02.07.2015)
Published in Nature communications (02.07.2015)
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Journal Article
Differential regulation of type III secretion and virulence genes in Bordetella pertussis and Bordetella bronchiseptica by a secreted anti-σ factor
Ahuja, Umesh, Shokeen, Bhumika, Cheng, Ning, Cho, Yeonjoo, Blum, Charles, Coppola, Giovanni, Miller, Jeff F.
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2016)
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Journal Article
SIRT1 Modulation as a Novel Approach to the Treatment of Diseases of Aging
Blum, Charles A, Ellis, James L, Loh, Christine, Ng, Pui Yee, Perni, Robert B, Stein, Ross L
Published in Journal of medicinal chemistry (27.01.2011)
Published in Journal of medicinal chemistry (27.01.2011)
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Journal Article
Mapping Gene Expression in Excitatory Neurons during Hippocampal Late-Phase Long-Term Potentiation
Chen, Patrick B, Kawaguchi, Riki, Blum, Charles, Achiro, Jennifer M, Coppola, Giovanni, O'Dell, Thomas J, Martin, Kelsey C
Published in Frontiers in molecular neuroscience (22.02.2017)
Published in Frontiers in molecular neuroscience (22.02.2017)
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Journal Article
Discovery and evaluation of pyrazolo[1,5- a]pyrimidines as neuropeptide Y1 receptor antagonists
Griffith, David A., Hargrove, Diane M., Maurer, Tristan S., Blum, Charles A., De Lombaert, Stéphane, Inthavongsay, John K., Klade, Lee E., Mack, Christine M., Rose, Colin R., Sanders, Martin J., Carpino, Philip A.
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
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Journal Article
Discovery of Novel 6,6-Heterocycles as Transient Receptor Potential Vanilloid (TRPV1) Antagonists
Blum, Charles A, Caldwell, Timothy, Zheng, Xiaozhang, Bakthavatchalam, Rajagopal, Capitosti, Scott, Brielmann, Harry, De Lombaert, Stéphane, Kershaw, Mark T, Matson, David, Krause, James E, Cortright, Daniel, Crandall, Marci, Martin, William J, Murphy, Beth Ann, Boyce, Susan, Jones, A. Brian, Mason, Glenn, Rycroft, Wayne, Perrett, Helen, Conley, Rachael, Burnaby-Davies, Nicola, Chenard, Bertrand L, Hodgetts, Kevin J
Published in Journal of medicinal chemistry (22.04.2010)
Published in Journal of medicinal chemistry (22.04.2010)
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Journal Article
Design, Synthesis, and Biological Evaluation of Substituted 2-Cyclohexyl-4-phenyl-1H-imidazoles: Potent and Selective Neuropeptide Y Y5-Receptor Antagonists
Blum, Charles A, Zheng, Xiaozhang, De Lombaert, Stéphane
Published in Journal of medicinal chemistry (22.04.2004)
Published in Journal of medicinal chemistry (22.04.2004)
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Journal Article
Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites
Hodgetts, Kevin J., Blum, Charles A., Caldwell, Timothy, Bakthavatchalam, Rajagopal, Zheng, Xiaozhang, Capitosti, Scott, Krause, James E., Cortright, Daniel, Crandall, Marci, Murphy, Beth Ann, Boyce, Susan, Brian Jones, A., Chenard, Bertrand L.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Journal Article
Aminoquinazolines as TRPV1 antagonists: Modulation of drug-like properties through the exploration of 2-position substitution
Blum, Charles A., Zheng, Xiaozhang, Brielmann, Harry, Hodgetts, Kevin J., Bakthavatchalam, Rajagopal, Chandrasekhar, Jayaraman, Krause, James E., Cortright, Daniel, Matson, David, Crandall, Marci, Ngo, Chu K., Fung, Lawrence, Day, Marta, Kershaw, Mark, De Lombaert, Stéphane, Chenard, Bertrand L.
Published in Bioorganic & medicinal chemistry (15.08.2008)
Published in Bioorganic & medicinal chemistry (15.08.2008)
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Journal Article
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
Szallasi, Arpad, Cortright, Daniel N, Blum, Charles A, Eid, Samer R
Published in Nature reviews. Drug discovery (01.06.2007)
Published in Nature reviews. Drug discovery (01.06.2007)
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Journal Article
From arylureas to biarylamides to aminoquinazolines: Discovery of a novel, potent TRPV1 antagonist
Zheng, Xiaozhang, Hodgetts, Kevin J., Brielmann, Harry, Hutchison, Alan, Burkamp, Frank, Brian Jones, A., Blurton, Peter, Clarkson, Robert, Chandrasekhar, Jayaraman, Bakthavatchalam, Rajagopal, De Lombaert, Stéphane, Crandall, Marci, Cortright, Daniel, Blum, Charles A.
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
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