A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice[S]
de Boer, Jan Freark, Verkade, Esther, Mulder, Niels L., de Vries, Hilde D., Huijkman, Nicolette, Koehorst, Martijn, Boer, Theo, Wolters, Justina C., Bloks, Vincent W., van de Sluis, Bart, Kuipers, Folkert
Published in Journal of lipid research (01.03.2020)
Published in Journal of lipid research (01.03.2020)
Get full text
Journal Article
In Utero Undernutrition in Male Mice Programs Liver Lipid Metabolism in the Second-Generation Offspring Involving Altered Lxra DNA Methylation
Martínez, Débora, Pentinat, Thais, Ribó, Sílvia, Daviaud, Christian, Bloks, Vincent W., Cebrià, Judith, Villalmanzo, Nuria, Kalko, Susana G., Ramón-Krauel, Marta, Díaz, Rubén, Plösch, Torsten, Tost, Jörg, Jiménez-Chillarón, Josep C.
Published in Cell metabolism (03.06.2014)
Published in Cell metabolism (03.06.2014)
Get full text
Journal Article
Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion
Jakulj, Lily, van Dijk, Theo H., de Boer, Jan Freark, Kootte, Ruud S., Schonewille, Marleen, Paalvast, Yared, Boer, Theo, Bloks, Vincent W., Boverhof, Renze, Nieuwdorp, Max, Beuers, Ulrich H.W., Stroes, Erik S.G., Groen, Albert K.
Published in Cell metabolism (13.12.2016)
Published in Cell metabolism (13.12.2016)
Get full text
Journal Article
Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction
van Zutphen, Tim, Ciapaite, Jolita, Bloks, Vincent W, Ackereley, Cameron, Gerding, Albert, Jurdzinski, Angelika, de Moraes, Roberta Allgayer, Zhang, Ling, Wolters, Justina C, Bischoff, Rainer, Wanders, Ronald J, Houten, Sander M, Bronte-Tinkew, Dana, Shatseva, Tatiana, Lewis, Gary F, Groen, Albert K, Reijngoud, Dirk-Jan, Bakker, Barbara M, Jonker, Johan W, Kim, Peter K, Bandsma, Robert H.J
Published in Journal of hepatology (01.12.2016)
Published in Journal of hepatology (01.12.2016)
Get full text
Journal Article
Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice
Schonewille, Marleen, Freark de Boer, Jan, Mele, Laura, Wolters, Henk, Bloks, Vincent W., Wolters, Justina C., Kuivenhoven, Jan A., Tietge, Uwe J.F., Brufau, Gemma, Groen, Albert K.
Published in Journal of lipid research (01.08.2016)
Published in Journal of lipid research (01.08.2016)
Get full text
Journal Article
Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content
Chen, Lianmin, van den Munckhof, Inge C.L., Schraa, Kiki, ter Horst, Rob, Koehorst, Martijn, van Faassen, Martijn, van der Ley, Claude, Doestzada, Marwah, Zhernakova, Daria V., Kurilshikov, Alexander, Bloks, Vincent W., Groen, Albert K., Riksen, Niels P., Rutten, Joost H.W., Joosten, Leo A.B., Wijmenga, Cisca, Zhernakova, Alexandra, Netea, Mihai G., Fu, Jingyuan, Kuipers, Folkert
Published in Cell reports (Cambridge) (06.10.2020)
Published in Cell reports (Cambridge) (06.10.2020)
Get full text
Journal Article
Hepatic Carbohydrate Response Element Binding Protein Activation Limits Nonalcoholic Fatty Liver Disease Development in a Mouse Model for Glycogen Storage Disease Type 1a
Lei, Yu, Hoogerland, Joanne A., Bloks, Vincent W., Bos, Trijnie, Bleeker, Aycha, Wolters, Henk, Wolters, Justina C., Hijmans, Brenda S., Dijk, Theo H., Thomas, Rachel, Weeghel, Michel, Mithieux, Gilles, Houtkooper, Riekelt H., Bruin, Alain, Rajas, Fabienne, Kuipers, Folkert, Oosterveer, Maaike H.
Published in Hepatology (Baltimore, Md.) (01.11.2020)
Published in Hepatology (Baltimore, Md.) (01.11.2020)
Get full text
Journal Article
An epigenome-wide association study identifies multiple DNA methylation markers of exposure to endocrine disruptors
Lu, Xueling, Fraszczyk, Eliza, van der Meer, Thomas P., van Faassen, Martijn, Bloks, Vincent W., Kema, Ido P., van Beek, André P., Li, Shuang, Franke, Lude, Westra, Harm-Jan, Xu, Xijin, Huo, Xia, Snieder, Harold, Wolffenbuttel, Bruce H.R., van Vliet-Ostaptchouk, Jana V.
Published in Environment international (01.11.2020)
Published in Environment international (01.11.2020)
Get full text
Journal Article
The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis
Heida, Andries, Gruben, Nanda, Catrysse, Leen, Koehorst, Martijn, Koster, Mirjam, Kloosterhuis, Niels J., Gerding, Albert, Havinga, Rick, Bloks, Vincent W., Bongiovanni, Laura, Wolters, Justina C., van Dijk, Theo, van Loo, Geert, de Bruin, Alain, Kuipers, Folkert, Koonen, Debby P.Y., van de Sluis, Bart
Published in Molecular metabolism (Germany) (01.12.2021)
Published in Molecular metabolism (Germany) (01.12.2021)
Get full text
Journal Article
FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements[S]
van Zutphen, Tim, Stroeve, Johanna H.M., Yang, Jiufang, Bloks, Vincent W., Jurdzinski, Angelika, Roelofsen, Han, Huijkman, Nicolette C.A., van Dijk, Theo H., Vonk, Roel J., van Deursen, Jan, Staels, Bart, Groen, Albert K., Kuipers, Folkert
Published in Journal of lipid research (01.09.2019)
Published in Journal of lipid research (01.09.2019)
Get full text
Journal Article
Low production of 12α-hydroxylated bile acids prevents hepatic steatosis in Cyp2c70−/− mice by reducing fat absorption
Li, Rumei, Palmiotti, Anna, de Vries, Hilde D., Hovingh, Milaine V., Koehorst, Martijn, Mulder, Niels L., Zhang, Yue, Kats, Kim, Bloks, Vincent W., Fu, Jingyuan, Verkade, Henkjan J., de Boer, Jan Freark, Kuipers, Folkert
Published in Journal of lipid research (01.01.2021)
Published in Journal of lipid research (01.01.2021)
Get full text
Journal Article
Identification of Side Chain Oxidized Sterols as Novel Liver X Receptor Agonists with Therapeutic Potential in the Treatment of Cardiovascular and Neurodegenerative Diseases
Zhan, Na, Wang, Boyang, Martens, Nikita, Liu, Yankai, Zhao, Shangge, Voortman, Gardi, van Rooij, Jeroen, Leijten, Frank, Vanmierlo, Tim, Kuipers, Folkert, Jonker, Johan W, Bloks, Vincent W, Lütjohann, Dieter, Palumbo, Marcella, Zimetti, Francesca, Adorni, Maria Pia, Liu, Hongbing, Mulder, Monique T
Published in International journal of molecular sciences (09.01.2023)
Published in International journal of molecular sciences (09.01.2023)
Get full text
Journal Article
Hepatic farnesoid X-receptor isoforms α2 and α4 differentially modulate bile salt and lipoprotein metabolism in mice
Boesjes, Marije, Bloks, Vincent W, Hageman, Jurre, Bos, Trijnie, van Dijk, Theo H, Havinga, Rick, Wolters, Henk, Jonker, Johan W, Kuipers, Folkert, Groen, Albert K
Published in PloS one (15.12.2014)
Published in PloS one (15.12.2014)
Get full text
Journal Article
Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism
Blankestijn, Maaike, Bloks, Vincent W., Struik, Dicky, Huijkman, Nicolette, Kloosterhuis, Niels, Wolters, Justina C., Wanders, Ronald J. A., Vaz, Frédéric M., Islinger, Markus, Kuipers, Folkert, van de Sluis, Bart, Groen, Albert K., Verkade, Henkjan J., Jonker, Johan W.
Published in Scientific reports (15.02.2022)
Published in Scientific reports (15.02.2022)
Get full text
Journal Article
Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia
van der Schoor, Lori W. E., Verkade, Henkjan J., Bertolini, Anna, de Wit, Sanne, Mennillo, Elvira, Rettenmeier, Eva, Weber, André A., Havinga, Rick, Valášková, Petra, Jašprová, Jana, Struik, Dicky, Bloks, Vincent W., Chen, Shujuan, Schreuder, Andrea B., Vítek, Libor, Tukey, Robert H., Jonker, Johan W.
Published in Scientific reports (27.05.2021)
Published in Scientific reports (27.05.2021)
Get full text
Journal Article
Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization study
Doestzada, Marwah, Zhernakova, Daria V, C L van den Munckhof, Inge, Wang, Daoming, Kurilshikov, Alexander, Chen, Lianmin, Bloks, Vincent W, van Faassen, Martijn, Rutten, Joost H W, Joosten, Leo A B, Netea, Mihai G, Wijmenga, Cisca, Riksen, Niels P, Zhernakova, Alexandra, Kuipers, Folkert, Fu, Jingyuan
Published in BMC medicine (15.12.2022)
Published in BMC medicine (15.12.2022)
Get full text
Journal Article
Pharmacological inhibition of MEK1/2 signaling disrupts bile acid metabolism through loss of Shp and enhanced Cyp7a1 expression
Verzijl, Cristy R.C., van de Peppel, Ivo P., Eilers, Roos E., Bloks, Vincent W., Wolters, Justina C., Koehorst, Martijn, Kloosterhuis, Niels J., Havinga, Rick, Jalving, Mathilde, Struik, Dicky, Jonker, Johan W.
Published in Biomedicine & pharmacotherapy (01.03.2023)
Published in Biomedicine & pharmacotherapy (01.03.2023)
Get full text
Journal Article
Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia
Doktorova, Marcela, Zwarts, Irene, Zutphen, Tim van, Dijk, Theo H. van, Bloks, Vincent W., Harkema, Liesbeth, Bruin, Alain de, Downes, Michael, Evans, Ronald M., Verkade, Henkjan J., Jonker, Johan W.
Published in Scientific reports (12.04.2017)
Published in Scientific reports (12.04.2017)
Get full text
Journal Article
Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet
Ronda, Onne A. H. O, van de Heijning, Bert J. M, de Bruin, Alain, Thomas, Rachel E, Martini, Ingrid, Koehorst, Martijn, Gerding, Albert, Koster, Mirjam H, Bloks, Vincent W, Jurdzinski, Angelika, Mulder, Niels L, Havinga, Rick, van der Beek, Eline M, Reijngoud, Dirk-Jan, Kuipers, Folkert, Verkade, Henkjan J, Greene, Michael W
Published in PloS one (21.09.2020)
Published in PloS one (21.09.2020)
Get full text
Journal Article
The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction
van Straten, Esther M. E, Bloks, Vincent W, Huijkman, Nicolette C. A, Baller, Julius F. W, Meer, Hester van, Lutjohann, Dieter, Kuipers, Folkert, Plosch, Torsten
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.02.2010)
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.02.2010)
Get full text
Journal Article