Tumour dose response to the antivascular agent ZD6126 assessed by magnetic resonance imaging
ROBINSON, S. P, MCINTYRE, D. J. O, CHECKLEY, D, TESSIER, J. J, HOWE, F. A, GRIFFITHS, J. R, ASHTON, S. E, RYAN, A. J, BLAKEY, D. C, WATERTON, J. C
Published in British journal of cancer (19.05.2003)
Published in British journal of cancer (19.05.2003)
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Liposomal encapsulation enhances the antitumour efficacy of the vascular disrupting agent ZD6126 in murine B16.F10 melanoma
FENS, M. H. A. M, HILL, K. J, ISSA, J, ASHTON, S. E, WESTWOOD, F. R, BLAKEY, D. C, STORM, G, RYAN, A. J, SCHIFFELERS, R. M
Published in British journal of cancer (21.10.2008)
Published in British journal of cancer (21.10.2008)
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A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo
Eberlein, C, Kendrew, J, McDaid, K, Alfred, A, Kang, J S, Jacobs, V N, Ross, S J, Rooney, C, Smith, N R, Rinkenberger, J, Cao, A, Churchman, A, Marshall, J F, Weir, H M, Bedian, V, Blakey, D C, Foltz, I N, Barry, S T
Published in Oncogene (12.09.2013)
Published in Oncogene (12.09.2013)
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Journal Article
A human monoclonal antibody 264RAD targeting alpha v beta 6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo
Eberlein, C, Kendrew, J, McDaid, K, Alfred, A, Kang, J S, Jacobs, V N, Ross, S J, Rooney, C, Smith, N R, Rinkenberger, J, Cao, A, Churchman, A, Marshall, J F, Weir, H M, Bedian, V, Blakey, D C, Foltz, I N, Barry, S T
Published in Oncogene (12.09.2013)
Published in Oncogene (12.09.2013)
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Journal Article
Induction of apoptosis by the ADEPT agent ZD2767: comparison with the classical nitrogen mustard chlorambucil and a monofunctional ZD2767 analogue
MONKS, N. R, BLAKEY, D. C, CURTIN, N. J, EAST, S. J, HEUZE, A, NEWELL, D. R
Published in British journal of cancer (01.09.2001)
Published in British journal of cancer (01.09.2001)
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Journal Article
Cellular glutathione as a determinant of the sensitivity of colorectal tumour cell-lines to ZD2767 antibody-directed enzyme prodrug therapy (ADEPT)
MONKS, N. R, CALVETE, J. A, CURTIN, N. J, BLAKEY, D. C, EAST, S. J, NEWELL, D. R
Published in British journal of cancer (01.07.2000)
Published in British journal of cancer (01.07.2000)
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Journal Article
Anti-tumour effects of an antibody-carboxypeptidase G2 conjugate in combination with phenol mustard prodrugs
BLAKEY, D. C, DAVIES, D. H, DOWELL, R. I, EAST, S. J, BURKE, P. J, SHARMA, S. K, SPRINGER, C. J, MAUGER, A. B, MELTON, R. G
Published in British journal of cancer (01.11.1995)
Published in British journal of cancer (01.11.1995)
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Journal Article
ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal tumor xenografts
BLAKEY, D. C, BURKE, P. J, PINDER, P. E, SHARMA, S. K, WRIGHT, A. F, SPRINGER, C. J, DAVIES, D. H, DOWELL, R. I, EAST, S. J, ECKERSLEY, K. P, FITTON, J. E, MCDAID, J, MELTON, R. G, NICULESCU-DUVAZ, I. A
Published in Cancer research (Chicago, Ill.) (15.07.1996)
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Published in Cancer research (Chicago, Ill.) (15.07.1996)
Journal Article
Purification of ricin A1, A2, and B chains and characterization of their toxicity
Fulton, R J, Blakey, D C, Knowles, P P, Uhr, J W, Thorpe, P E, Vitetta, E S
Published in The Journal of biological chemistry (25.04.1986)
Published in The Journal of biological chemistry (25.04.1986)
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Journal Article
New Mustard Prodrugs for Antibody-Directed Enzyme Prodrug Therapy: Alternatives to the Amide Link
Dowell, Robert I, Springer, Caroline J, Davies, David H, Hadley, Elizabeth M, Burke, Philip J, Boyle, F. Thomas, Melton, Roger G, Connors, Thomas A, Blakey, David C, Mauger, Anthony B
Published in Journal of medicinal chemistry (01.03.1996)
Published in Journal of medicinal chemistry (01.03.1996)
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Journal Article
Antibody-directed enzyme prodrug therapy (ADEPT) for treatment of major solid tumour disease
Blakey, D C, Burke, P J, Davies, D H, Dowell, R I, Melton, R G, Springer, C J, Wright, A F
Published in Biochemical Society transactions (01.11.1995)
Published in Biochemical Society transactions (01.11.1995)
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Journal Article
ZD6126: A novel small molecule vascular targeting agent
Blakey, David C, Ashton, Susan E, Westwood, F.Russell, Walker, Mike, Ryan, Anderson J
Published in International journal of radiation oncology, biology, physics (01.12.2002)
Published in International journal of radiation oncology, biology, physics (01.12.2002)
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Journal Article
Conference Proceeding
Antitumor effects of an antibody-carboxypeptidase G2 conjugate in combination with a benzoic acid mustard prodrug
Blakey, D C, Valcaccia, B E, East, S, Wright, A F, Boyle, F T, Springer, C J, Burke, P J, Melton, R G, Bagshawe, K D
Published in Cell biophysics (01.01.1993)
Published in Cell biophysics (01.01.1993)
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Journal Article
Comparison of the pharmacokinetics and hepatotoxic effects of saporin and ricin A-chain immunotoxins on murine liver parenchymal cells
BLAKEY, D. C, SKILLETER, D. N, PRICE, R. J, WATSON, G. J, HART, L. I, NEWELL, D. R, THORPE, P. E
Published in Cancer research (Chicago, Ill.) (15.12.1988)
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Published in Cancer research (Chicago, Ill.) (15.12.1988)
Journal Article
New coupling agents for the synthesis of immunotoxins containing a hindered disulfide bond with improved stability in vivo
THORPE, P. E, WALLACE, P. M, KNOWLES, P. P, RELF, M. G, BROWN, A. N. F, WATSON, G. J, KNYBA, R. E, WAWRZYNCZAK, E. J, BLAKEY, D. C
Published in Cancer research (Chicago, Ill.) (15.11.1987)
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Published in Cancer research (Chicago, Ill.) (15.11.1987)
Journal Article
Optimization of Alkylating Agent Prodrugs Derived from Phenol and Aniline Mustards: A New Clinical Candidate Prodrug (ZD2767) for Antibody-Directed Enzyme Prodrug Therapy
Springer, Caroline J, Dowell, Robert, Burke, Philip J, Hadley, Elma, Davies, D. Huw, Blakey, David C, Melton, Roger G, Niculescu-Duvaz, Ion
Published in Journal of medicinal chemistry (01.12.1995)
Published in Journal of medicinal chemistry (01.12.1995)
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