Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β
Arndt, Joseph W, Qian, Fang, Smith, Benjamin A, Quan, Chao, Kilambi, Krishna Praneeth, Bush, Martin W, Walz, Thomas, Pepinsky, R Blake, Bussière, Thierry, Hamann, Stefan, Cameron, Thomas O, Weinreb, Paul H
Published in Scientific reports (23.04.2018)
Published in Scientific reports (23.04.2018)
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Journal Article
Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models
Weihofen, Andreas, Liu, YuTing, Arndt, Joseph W., Huy, Christian, Quan, Chao, Smith, Benjamin A., Baeriswyl, Jean-Luc, Cavegn, Nicole, Senn, Luzia, Su, Lihe, Marsh, Galina, Auluck, Pavan K., Montrasio, Fabio, Nitsch, Roger M., Hirst, Warren D., Cedarbaum, Jesse M., Pepinsky, R. Blake, Grimm, Jan, Weinreb, Paul H.
Published in Neurobiology of disease (01.04.2019)
Published in Neurobiology of disease (01.04.2019)
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Journal Article
LINGO-1 negatively regulates myelination by oligodendrocytes
Mi, Sha, Miller, Robert H, Lee, Xinhua, Scott, Martin L, Shulag-Morskaya, Svetlane, Shao, Zhaohui, Chang, Jufang, Thill, Greg, Levesque, Melissa, Zhang, Mingdi, Hession, Cathy, Sah, Dinah, Trapp, Bruce, He, Zhigang, Jung, Vincent, McCoy, John M, Pepinsky, R Blake
Published in Nature neuroscience (01.06.2005)
Published in Nature neuroscience (01.06.2005)
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Journal Article
LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury
Ji, Benxiu, Li, Mingwei, Wu, Wu-Tian, Yick, Leung-Wah, Lee, Xinhua, Shao, Zhaohui, Wang, Joy, So, Kwok-Fai, McCoy, John M., Blake Pepinsky, R., Mi, Sha, Relton, Jane K.
Published in Molecular and cellular neuroscience (01.11.2006)
Published in Molecular and cellular neuroscience (01.11.2006)
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Journal Article
LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex
Mi, Sha, Lee, Xinhua, Shao, Zhaohui, Thill, Greg, Ji, Benxiu, Relton, Jane, Levesque, Melissa, Allaire, Norm, Perrin, Steve, Sands, Bryan, Crowell, Thomas, Cate, Richard L, McCoy, John M, Pepinsky, R Blake
Published in Nature neuroscience (01.03.2004)
Published in Nature neuroscience (01.03.2004)
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Journal Article
Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination
Mi, Sha, Lee, Xinhua, Hu, Yinghui, Ji, Benxiu, Shao, Zhaohui, Yang, Weixing, Huang, Guanrong, Walus, Lee, Rhodes, Kenneth, Gong, Bang Jian, Miller, Robert H, Pepinsky, R Blake
Published in Nature medicine (01.07.2011)
Published in Nature medicine (01.07.2011)
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Journal Article
Improving the solubility of anti‐LINGO‐1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis
Pepinsky, R. Blake, Silvian, Laura, Berkowitz, Steven A., Farrington, Graham, Lugovskoy, Alexey, Walus, Lee, Eldredge, John, Capili, Allan, Mi, Sha, Graff, Christilyn, Garber, Ellen
Published in Protein science (01.05.2010)
Published in Protein science (01.05.2010)
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Journal Article
Constitutive negative regulation in the processing of the anti-Müllerian hormone receptor II
Hirschhorn, Tal, di Clemente, Nathalie, Amsalem, Ayelet R, Pepinsky, R Blake, Picard, Jean-Yves, Smorodinsky, Nechama I, Cate, Richard L, Ehrlich, Marcelo
Published in Journal of cell science (01.04.2015)
Published in Journal of cell science (01.04.2015)
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Journal Article
NGF Regulates the Expression of Axonal LINGO-1 to Inhibit Oligodendrocyte Differentiation and Myelination
Lee, Xinhua, Yang, Zhongshu, Shao, Zhaohui, Rosenberg, Sheila S, Levesque, Melissa, Pepinsky, R. Blake, Qiu, Mengsheng, Miller, Robert H, Chan, Jonah R, Mi, Sha
Published in The Journal of neuroscience (03.01.2007)
Published in The Journal of neuroscience (03.01.2007)
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Journal Article
TAJ/TROY, an Orphan TNF Receptor Family Member, Binds Nogo-66 Receptor 1 and Regulates Axonal Regeneration
Shao, Zhaohui, Browning, Jeffrey L., Lee, Xinhua, Scott, Martin L., Shulga-Morskaya, Sveltlana, Allaire, Norm, Thill, Greg, Levesque, Melissa, Sah, Dinah, McCoy, John M., Murray, Beth, Jung, Vincent, Pepinsky, R. Blake, Mi, Sha
Published in Neuron (Cambridge, Mass.) (03.02.2005)
Published in Neuron (Cambridge, Mass.) (03.02.2005)
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Journal Article
Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site
Hanf, Karl J M, Arndt, Joseph W, Liu, YuTing, Gong, Bang Jian, Rushe, Mia, Sopko, Richelle, Massol, Ramiro, Smith, Benjamin, Gao, Yan, Dalkilic-Liddle, Isin, Lee, Xinhua, Mojta, Shanell, Shao, Zhaohui, Mi, Sha, Pepinsky, R Blake
Published in mAbs (01.01.2020)
Published in mAbs (01.01.2020)
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Journal Article
Blocking LINGO-1 Function Promotes Retinal Ganglion Cell Survival Following Ocular Hypertension and Optic Nerve Transection
Fu, Qing-Ling, Hu, Bing, Wu, Wutian, Pepinsky, R. Blake, Mi, Sha, So, Kwok-Fai
Published in Investigative ophthalmology & visual science (01.03.2008)
Published in Investigative ophthalmology & visual science (01.03.2008)
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Journal Article
The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
Isner, Jeffrey M, Pola, Roberto, Ling, Leona E, Silver, Marcy, Corbley, Michael J, Kearney, Marianne, Blake Pepinsky, R, Shapiro, Renee, Taylor, Frederick R, Baker, Darren P, Asahara, Takayuki
Published in Nature medicine (01.06.2001)
Published in Nature medicine (01.06.2001)
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Journal Article
Efficient on-column conversion of IgG₁ trisulfide linkages to native disulfides in tandem with Protein A affinity chromatography
Aono, Hiromasa, Wen, Dingy, Zang, Li, Houde, Damian, Pepinsky, R. Blake, Evans, David R.H
Published in Journal of Chromatography A (01.08.2010)
Published in Journal of Chromatography A (01.08.2010)
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Journal Article
Development and validation of immunoassays to quantify the half-antibody exchange of an IgG4 antibody, natalizumab (Tysabri ®) with endogenous IgG4
Shapiro, Renée I., Plavina, Tatiana, Schlain, Brian R., Pepinsky, R. Blake, Garber, Ellen A., Jarpe, Matthew, Hochman, Paula S., Wehner, Nancy G., Bard, Frederique, Motter, Ruth, Yednock, Ted A., Taylor, Frederick R.
Published in Journal of pharmaceutical and biomedical analysis (28.04.2011)
Published in Journal of pharmaceutical and biomedical analysis (28.04.2011)
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Journal Article
Antibody humanization by redesign of complementarity-determining region residues proximate to the acceptor framework
Hanf, Karl J.M., Arndt, Joseph W., Chen, Ling Ling, Jarpe, Matthew, Boriack-Sjodin, P. Ann, Li, You, van Vlijmen, Herman W.T., Pepinsky, R. Blake, Simon, Kenneth J., Lugovskoy, Alexey
Published in Methods (San Diego, Calif.) (01.01.2014)
Published in Methods (San Diego, Calif.) (01.01.2014)
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Journal Article
Production of a PEGylated Fab′ of the anti-LINGO-1 Li33 Antibody and Assessment of Its Biochemical and Functional Properties in Vitro and in a Rat Model of Remyelination
Pepinsky, R. Blake, Walus, Lee, Shao, Zhaohui, Ji, Benxiu, Gu, Sheng, Sun, Yaping, Wen, Dingyi, Lee, Xinhua, Wang, Qin, Garber, Ellen, Mi, Sha
Published in Bioconjugate chemistry (16.02.2011)
Published in Bioconjugate chemistry (16.02.2011)
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Journal Article
IGF-1:Tetanus toxin fragment C fusion protein improves delivery of IGF-1 to spinal cord but fails to prolong survival of ALS mice
Chian, Ru-Ju, Li, Jianhong, Ay, Ilknur, Celia, Samuel A, Kashi, Brenda B, Tamrazian, Eric, Matthews, Jonathan C, Bronson, Roderick T, Rossomando, Anthony, Pepinsky, R. Blake, Fishman, Paul S, Brown, Robert H, Francis, Jonathan W
Published in Brain research (01.09.2009)
Published in Brain research (01.09.2009)
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Journal Article
The anti-Müllerian hormone prodomain is displaced from the hormone/prodomain complex upon bivalent binding to the hormone receptor
Cate, Richard L., di Clemente, Nathalie, Racine, Chrystèle, Groome, Nigel P., Pepinsky, R. Blake, Whitty, Adrian
Published in The Journal of biological chemistry (01.01.2022)
Published in The Journal of biological chemistry (01.01.2022)
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