The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer
Diefenbacher, Markus E, Popov, Nikita, Blake, Sophia M, Schülein-Völk, Christina, Nye, Emma, Spencer-Dene, Bradley, Jaenicke, Laura A, Eilers, Martin, Behrens, Axel
Published in The Journal of clinical investigation (01.08.2014)
Published in The Journal of clinical investigation (01.08.2014)
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Discovery of Novel Spiro[3H‑indole-3,2′-pyrrolidin]-2(1H)‑one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction
Gollner, Andreas, Rudolph, Dorothea, Arnhof, Heribert, Bauer, Markus, Blake, Sophia M, Boehmelt, Guido, Cockroft, Xiao-Ling, Dahmann, Georg, Ettmayer, Peter, Gerstberger, Thomas, Karolyi-Oezguer, Jale, Kessler, Dirk, Kofink, Christiane, Ramharter, Juergen, Rinnenthal, Jörg, Savchenko, Alexander, Schnitzer, Renate, Weinstabl, Harald, Weyer-Czernilofsky, Ulrike, Wunberg, Tobias, McConnell, Darryl B
Published in Journal of medicinal chemistry (23.11.2016)
Published in Journal of medicinal chemistry (23.11.2016)
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Usp28 counteracts Fbw7 in intestinal homeostasis and cancer
Diefenbacher, Markus E, Chakraborty, Atanu, Blake, Sophia M, Mitter, Richard, Popov, Nikita, Eilers, Martin, Behrens, Axel
Published in Cancer research (Chicago, Ill.) (01.04.2015)
Published in Cancer research (Chicago, Ill.) (01.04.2015)
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Inducible knock-out of BCL6 in lymphoma cells results in tumor stasis
Schlager, Stefanie, Salomon, Carina, Olt, Sabine, Albrecht, Christoph, Ebert, Anja, Bergner, Oliver, Wachter, Johannes, Trapani, Francesca, Gerlach, Daniel, Voss, Tilman, Traunbauer, Anna, Jude, Julian, Hinterndorfer, Matthias, Minnich, Martina, Schweifer, Norbert, Blake, Sophia M, Zinzalla, Vittoria, Drobits, Barbara, McConnell, Darryl B, Kraut, Norbert, Pearson, Mark, Zuber, Johannes, Koegl, Manfred
Published in Oncotarget (03.03.2020)
Published in Oncotarget (03.03.2020)
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Differential Functions of ApoER2 and Very Low Density Lipoprotein Receptor in Reelin Signaling Depend on Differential Sorting of the Receptors
Duit, Sarah, Mayer, Harald, Blake, Sophia M, Schneider, Wolfgang J, Nimpf, Johannes
Published in The Journal of biological chemistry (12.02.2010)
Published in The Journal of biological chemistry (12.02.2010)
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The paradoxical role of cytokines and chemokines at the tumor microenvironment: a comprehensive review
Abdul-Rahman, Toufik, Ghosh, Shankhaneel, Badar, Sarah M, Nazir, Abubakar, Bamigbade, Gafar Babatunde, Aji, Narjiss, Roy, Poulami, Kachani, Hajar, Garg, Neil, Lawal, Lukman, Bliss, Zarah Sophia Blake, Wireko, Andrew Awuah, Atallah, Oday, Adebusoye, Favour Tope, Teslyk, Tetiana, Sikora, Kateryna, Horbas, Viktoriia
Published in European journal of medical research (15.02.2024)
Published in European journal of medical research (15.02.2024)
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Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation
Blake, Sophia M, Stricker, Stefan H, Halavach, Hanna, Poetsch, Anna R, Cresswell, George, Kelly, Gavin, Kanu, Nnennaya, Marino, Silvia, Luscombe, Nicholas M, Pollard, Steven M, Behrens, Axel
Published in eLife (17.03.2016)
Published in eLife (17.03.2016)
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ApoER2/VLDL Receptor and Dab1 in the Rostral Migratory Stream Function in Postnatal Neuronal Migration Independently of Reelin
Andrade, Nuno, Komnenovic, Vukoslav, Blake, Sophia M., Jossin, Yves, Howell, Brian, Goffinet, Andre, Schneider, Wolfgang J., Nimpf, Johannes
Published in Proceedings of the National Academy of Sciences - PNAS (15.05.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (15.05.2007)
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BI-907828, a novel potent MDM2 inhibitor, inhibits glioblastoma brain tumor stem cells in vitro and prolongs survival in orthotopic xenograft mouse models
Hao, Xiaoguang, Bahia, Ravinder K, Cseh, Orsolya, Bozek, Danielle A, Blake, Sophia, Rinnenthal, Jörg, Weyer-Czernilofsky, Ulrike, Rudolph, Dorothea, Artee Luchman, H
Published in Neuro-oncology (Charlottesville, Va.) (04.05.2023)
Published in Neuro-oncology (Charlottesville, Va.) (04.05.2023)
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Abstract 3084: BI-907828: A novel, potent MDM2 inhibitor, inhibits GBM brain tumor stem cells in vitro and prolonged survival in orthotopic xenograft mouse models
Luchman, Hema A., Bozek, Danielle, Hao, Xiaoguang, Rudolph, Dorothea, Blake, Sophia, Rinnenthal, Jörg, Weiss, Samuel
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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First-in-human phase I trial of the oral first-in-class ubiquitin specific peptidase 1 (USP1) inhibitor KSQ-4279 (KSQi), given as single agent (SA) and in combination with olaparib (OLA) or carboplatin (CARBO) in patients (pts) with advanced solid tumors, enriched for deleterious homologous recombination repair (HRR) mutations
Yap, Timothy A., Lakhani, Nehal J., Patnaik, Amita, Lee, Elizabeth Katherine, Gutierrez, Martin, Moore, Kathleen N., Carneiro, Benedito A., Hays, John L., Huang, Marilyn, LoRusso, Patricia, Wylie, Andrew, Cadzow, Louise, Goulet, Matthew, Tobin, Erica, Krieter, Oliver, Schmid, Daniela, Blake, Sophia M., Dieterich, Max, Jamois, Candice, Harris, Patricia M.
Published in Journal of clinical oncology (01.06.2024)
Published in Journal of clinical oncology (01.06.2024)
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RNA in cardiovascular disease: A new frontier of personalized medicine
Abdul-Rahman, Toufik, Lizano-Jubert, Ileana, Bliss, Zarah Sophia Blake, Garg, Neil, Meale, Emily, Roy, Poulami, Crino, Salvatore Antonio, Deepak, Bethineedi Lakshmi, Miteu, Goshen David, Wireko, Andrew Awuah, Qadeer, Abdul, Condurat, Alexandra, Tanasa, Andra Diana, Pyrpyris, Nikolaos, Sikora, Kateryna, Horbas, Viktoriia, Sood, Aayushi, Gupta, Rahul, Lavie, Carl J.
Published in Progress in cardiovascular diseases (01.07.2024)
Published in Progress in cardiovascular diseases (01.07.2024)
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Allergic sensitization impairs lung resident memory CD8 T-cell response and virus clearance
Agrawal, Komal, Ong, Li Ching, Monkley, Susan, Thörn, Kristofer, Israelsson, Elisabeth, Baturcam, Engin, Rist, Cassie, Schön, Karin, Blake, Sophia, Magnusson, Björn, Cartwright, James, Mitra, Suman, Ravi, Abilash, Zounemat-Kermani, Nazanin, Krishnaswamy, Jayendra Kumar, Lycke, Nils Y., Gehrmann, Ulf, Mattsson, Johan
Published in Journal of allergy and clinical immunology (01.12.2022)
Published in Journal of allergy and clinical immunology (01.12.2022)
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Abstract DDT01-01: BI 905677: A first-in-class LRP5/6 antagonist targeting Wnt-driven proliferation and immune escape
Zinzalla, Vittoria, Drobits-Handl, Barbara, Savchenko, Alexander, Rinnenthal, Jörg, Bauer, Markus Johann, Sanderson, Michael, Blake, Sophia Maria, Schweifer, Norbert, Vries, Robert Gerhardus Jacob, Clevers, Hans, Kraut, Norbert
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 3197: BI-907828, a novel and potent MDM2-p53 antagonist, acts synergistically in a triple combination with anti-PD-1 and anti-LAG-3 antibodies in syngeneic mouse models of cancer
Rudolph, Dorothea, Weyer-Czernilofsky, Ulrike, Reschke, Markus, Sykora, Martina, Rinnenthal, Jörg, Blake, Sophia, Gremel, Gabriela, Wernitznig, Andreas, Gollner, Andreas, Kraut, Norbert, Moll, Jürgen
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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The impact of air quality on cardiovascular health: A state of the art review
Abdul-Rahman, Toufik, Roy, Poulami, Bliss, Zarah Sophia Blake, Mohammad, Abdulkader, Corriero, Anna Chiara, Patel, Neal T, Wireko, Andrew Awuah, Shaikh, Raheel, Faith, Ogungbemi Evelyn, Arevalo-Rios, Einer Carlos Eduardo, Dupuis, Léonie, Ulusan, Sebahat, Erbay, Muhammed Ibrahim, Cedeño, Mario Villalobos, Sood, Aayushi, Gupta, Rahul
Published in Current problems in cardiology (01.02.2024)
Published in Current problems in cardiology (01.02.2024)
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