Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine Aurora Kinase Inhibitors
Wang, Shudong, Midgley, Carol A, Scaërou, Frederic, Grabarek, Joanna B, Griffiths, Gary, Jackson, Wayne, Kontopidis, George, McClue, Steven J, McInnes, Campbell, Meades, Christopher, Mezna, Mokdad, Plater, Andy, Stuart, Iain, Thomas, Mark P, Wood, Gavin, Clarke, Rosemary G, Blake, David G, Zheleva, Daniella I, Lane, David P, Jackson, Robert C, Glover, David M, Fischer, Peter M
Published in Journal of medicinal chemistry (10.06.2010)
Published in Journal of medicinal chemistry (10.06.2010)
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High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase
Walker, Roderick G, Thomson, Graeme, Malone, Kirk, Nowicki, Matthew W, Brown, Elaine, Blake, David G, Turner, Nicholas J, Walkinshaw, Malcolm D, Grant, Karen M, Mottram, Jeremy C
Published in PLoS neglected tropical diseases (01.04.2011)
Published in PLoS neglected tropical diseases (01.04.2011)
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The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1
Pearson, Russell J, Blake, David G, Mezna, Mokdad, Fischer, Peter M, Westwood, Nicholas J, McInnes, Campbell
Published in Cell chemical biology (20.09.2018)
Published in Cell chemical biology (20.09.2018)
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Design, Synthesis, and Evaluation of 2-Methyl- and 2-Amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as Ring-Constrained 2-Anilino-4-(thiazol-5-yl)pyrimidine Cyclin-Dependent Kinase Inhibitors
McIntyre, Neil A, McInnes, Campbell, Griffiths, Gary, Barnett, Anna L, Kontopidis, George, Slawin, Alexandra M. Z, Jackson, Wayne, Thomas, Mark, Zheleva, Daniella I, Wang, Shudong, Blake, David G, Westwood, Nicholas J, Fischer, Peter M
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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A Quantitative Study of the in Vitro Binding of the C-Terminal Domain of p21 to PCNA: Affinity, Stoichiometry, and Thermodynamics
Zheleva, Daniella I, Zhelev, Nikolai Z, Fischer, Peter M, Duff, Susan V, Warbrick, Emma, Blake, David G, Lane, David P
Published in Biochemistry (Easton) (27.06.2000)
Published in Biochemistry (Easton) (27.06.2000)
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Discovery and Characterization of 2-Anilino-4- (Thiazol-5-yl)Pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents
Wang, Shudong, Griffiths, Gary, Midgley, Carol A., Barnett, Anna L., Cooper, Michael, Grabarek, Joanna, Ingram, Laura, Jackson, Wayne, Kontopidis, George, McClue, Steven J., McInnes, Campbell, McLachlan, Janice, Meades, Christopher, Mezna, Mokdad, Stuart, Iain, Thomas, Mark P., Zheleva, Daniella I., Lane, David P., Jackson, Robert C., Glover, David M., Blake, David G., Fischer, Peter M.
Published in Chemistry & biology (29.10.2010)
Published in Chemistry & biology (29.10.2010)
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Abstract 5666: DNA repair defects enhance tumor cell sensitivity to sapacitabine
Frame, Sheelagh, Armour, Sian, Zheleva, Daniella I., Green, Simon R., Blake, David G.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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