Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia
Shi, Yuzhe, Beckett, Melanie C, Blair, Helen J, Tirtakusuma, Ricky, Nakjang, Sirintra, Enshaei, Amir, Halsey, Christina, Vormoor, Josef, Heidenreich, Olaf, Krippner-Heidenreich, Anja, van Delft, Frederik W
Published in Haematologica (Roma) (01.04.2021)
Published in Haematologica (Roma) (01.04.2021)
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The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation
Martinez-Soria, Natalia, McKenzie, Lynsey, Draper, Julia, Ptasinska, Anetta, Issa, Hasan, Potluri, Sandeep, Blair, Helen J., Pickin, Anna, Isa, Asmida, Chin, Paulynn Suyin, Tirtakusuma, Ricky, Coleman, Daniel, Nakjang, Sirintra, Assi, Salam, Forster, Victoria, Reza, Mojgan, Law, Ed, Berry, Philip, Mueller, Dorothee, Osborne, Cameron, Elder, Alex, Bomken, Simon N., Pal, Deepali, Allan, James M., Veal, Gareth J., Cockerill, Peter N., Wichmann, Christian, Vormoor, Josef, Lacaud, Georges, Bonifer, Constanze, Heidenreich, Olaf
Published in Cancer cell (08.10.2018)
Published in Cancer cell (08.10.2018)
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Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth
Kellaway, Sophie G, Potluri, Sandeep, Keane, Peter, Blair, Helen J, Ames, Luke, Worker, Alice, Chin, Paulynn S, Ptasinska, Anetta, Derevyanko, Polina K, Adamo, Assunta, Coleman, Daniel J L, Khan, Naeem, Assi, Salam A, Krippner-Heidenreich, Anja, Raghavan, Manoj, Cockerill, Peter N, Heidenreich, Olaf, Bonifer, Constanze
Published in Nature communications (14.02.2024)
Published in Nature communications (14.02.2024)
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Disruption to the FOXO-PRDM1 axis resulting from deletions of chromosome 6 in acute lymphoblastic leukaemia
Sinclair, Paul B, Cranston, Ruth E, Raninga, Prahlad, Cheng, Joanna, Hanna, Rebecca, Hawking, Zoe, Hair, Steven, Ryan, Sarra L, Enshaei, Amir, Nakjang, Sirintra, Rand, Vikki, Blair, Helen J, Moorman, Anthony V, Heidenreich, Olaf, Harrison, Christine J
Published in Leukemia (01.03.2023)
Published in Leukemia (01.03.2023)
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Targeting WEE1 kinase as a p53-independent therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia
Bell, Hayden L., Blair, Helen J., Singh, Mankaran, Moorman, Anthony V., Heidenreich, Olaf, van Delft, Frederik W., Lunec, John, Irving, Julie A. E.
Published in Cancer cell international (15.09.2023)
Published in Cancer cell international (15.09.2023)
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Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia
Ruiz-Perez, Victor L, Blair, Helen J, Rodriguez-Andres, M Elena, Blanco, Maria Jose, Wilson, Amy, Liu, Yu-Ning, Miles, Colin, Peters, Heiko, Goodship, Judith A
Published in Development (Cambridge) (01.08.2007)
Published in Development (Cambridge) (01.08.2007)
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Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus
Blair, Helen J, Tompson, Stuart, Liu, Yu-Ning, Campbell, Jennifer, MacArthur, Katie, Ponting, Chris P, Ruiz-Perez, Victor L, Goodship, Judith A
Published in BMC biology (28.02.2011)
Published in BMC biology (28.02.2011)
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Inhibition of ATR acutely sensitizes acute myeloid leukemia cells to nucleoside analogs that target ribonucleotide reductase
Fordham, Sarah E., Blair, Helen J., Elstob, Claire J., Plummer, Ruth, Drew, Yvette, Curtin, Nicola J., Heidenreich, Olaf, Pal, Deepali, Jamieson, David, Park, Catherine, Pollard, John, Fields, Scott, Milne, Paul, Jackson, Graham H., Marr, Helen J., Menne, Tobias, Jones, Gail L., Allan, James M.
Published in Blood advances (22.05.2018)
Published in Blood advances (22.05.2018)
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Mutations in Two Nonhomologous Genes in a Head-to-Head Configuration Cause Ellis-van Creveld Syndrome
Ruiz-Perez, Victor L., Stuart Tompson, W.J., Helen Blair, J., Espinoza-Valdez, Cecilia, Lapunzina, Pablo, Silva, Elias O., Hamel, Ben, Gibbs, John L., Young, Ian D., Wright, Michael J., Goodship, Judith A.
Published in American journal of human genetics (01.03.2003)
Published in American journal of human genetics (01.03.2003)
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Fusion transcripts are present in early progenitor cells in KMT2A-rearranged B-ALL
Tirtakusuma, Ricky, Milne, Paul, Blair, Helen J, Shi, Yuzhe, Bomken, Simon, Heidenreich, Olaf
Published in Leukemia (01.04.2024)
Published in Leukemia (01.04.2024)
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Sequencing EVC and EVC2 identifies mutations in two-thirds of Ellis-van Creveld syndrome patients
TOMPSON, Stuart W. J, RUIZ-PEREZ, Victor L, BLAIR, Helen J, BARTON, Stephanie, NAVARRO, Victoria, ROBSON, Joanne L, WRIGHT, Michael J, GOODSHIP, Judith A
Published in Human genetics (01.01.2007)
Published in Human genetics (01.01.2007)
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Synthesis and In Vivo Evaluation of a Site-specifically Labeled Radioimmunoconjugate for Dual-Modal (PET/NIRF) Imaging of MT1-MMP in Sarcomas
Pringle, Toni A., Chan, Corey D., Luli, Saimir, Blair, Helen J., Rankin, Kenneth S., Knight, James C.
Published in Bioconjugate chemistry (17.08.2022)
Published in Bioconjugate chemistry (17.08.2022)
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Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia
Tirtakusuma, Ricky, Szoltysek, Katarzyna, Milne, Paul, Grinev, Vasily V., Ptasinska, Anetta, Chin, Paulynn S., Meyer, Claus, Nakjang, Sirintra, Hehir-Kwa, Jayne Y., Williamson, Daniel, Cauchy, Pierre, Keane, Peter, Assi, Salam A., Ashtiani, Minoo, Kellaway, Sophie G., Imperato, Maria R., Vogiatzi, Fotini, Schweighart, Elizabeth K., Lin, Shan, Wunderlich, Mark, Stutterheim, Janine, Komkov, Alexander, Zerkalenkova, Elena, Evans, Paul, McNeill, Hesta, Elder, Alex, Martinez-Soria, Natalia, Fordham, Sarah E., Shi, Yuzhe, Russell, Lisa J., Pal, Deepali, Smith, Alex, Kingsbury, Zoya, Becq, Jennifer, Eckert, Cornelia, Haas, Oskar A., Carey, Peter, Bailey, Simon, Skinner, Roderick, Miakova, Natalia, Collin, Matthew, Bigley, Venetia, Haniffa, Muzlifah, Marschalek, Rolf, Harrison, Christine J., Cargo, Catherine A., Schewe, Denis, Olshanskaya, Yulia, Thirman, Michael J., Cockerill, Peter N., Mulloy, James C., Blair, Helen J., Vormoor, Josef, Allan, James M., Bonifer, Constanze, Heidenreich, Olaf, Bomken, Simon
Published in Blood (27.10.2022)
Published in Blood (27.10.2022)
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Combination p53 activation and BCL-xL/BCL-2 inhibition as a therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia
Bell, Hayden L., Blair, Helen J., Jepson Gosling, Samantha J., Galler, Martin, Astley, Daniel, Moorman, Anthony V., Heidenreich, Olaf, Veal, Gareth J., van Delft, Frederik W., Lunec, John, Irving, Julie A. E.
Published in Leukemia (01.06.2024)
Published in Leukemia (01.06.2024)
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A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Assay Identifies Nilotinib as an Inhibitor of Inflammation in Acute Myeloid Leukemia
Marín-Rubio, José Luis, Peltier-Heap, Rachel E., Dueñas, Maria Emilia, Heunis, Tiaan, Dannoura, Abeer, Inns, Joseph, Scott, Jonathan, Simpson, A. John, Blair, Helen J., Heidenreich, Olaf, Allan, James M., Watt, Jessica E., Martin, Mathew P., Saxty, Barbara, Trost, Matthias
Published in Journal of medicinal chemistry (22.09.2022)
Published in Journal of medicinal chemistry (22.09.2022)
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The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation
Martinez-Soria, Natalia, McKenzie, Lynsey, Draper, Julia, Ptasinska, Anetta, Issa, Hasan, Potluri, Sandeep, Blair, Helen J., Pickin, Anna, Isa, Asmida, Chin, Paulynn Suyin, Tirtakusuma, Ricky, Coleman, Daniel, Nakjang, Sirintra, Assi, Salam, Forster, Victoria, Reza, Mojgan, Law, Ed, Berry, Philip, Mueller, Dorothee, Osborne, Cameron, Elder, Alex, Bomken, Simon N., Pal, Deepali, Allan, James M., Veal, Gareth J., Cockerill, Peter N., Wichmann, Christian, Vormoor, Josef, Lacaud, Georges, Bonifer, Constanze, Heidenreich, Olaf
Published in Cancer cell (15.04.2019)
Published in Cancer cell (15.04.2019)
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Dual Targeting of MDM2 and BCL2/Bclxl Demonstrates Potent Synergistic Activity in High-Risk Adult Acute Lymphoblastic Leukemia
Bell, Hayden L, Singh, Mankaran, Blair, Helen J, Heidenreich, Olaf, van Delft, Frederik W., Moorman, Anthony V., Lunec, John, Irving, Julie
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Preclinical Investigation of the p53-MDM2 Antagonist Idasanutlin (RG7388) Demonstrates Significant Activity in High Risk Adult Acute Lymphoblastic Leukemia
Bell, Hayden L, Singh, Mankaran, Blair, Helen J, van Delft, Frederik W., Moorman, Anthony V., Lunec, John, Irving, Julie
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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MDB-74. SERINE/GLYCINE METABOLISM REPRESENTS A NOVEL TARGETABLE THERAPEUTIC VULNERABILITY IN MYC-AMPLIFIED MEDULLOBLASTOMA
Adiamah, Magretta, Poole, Bethany, Lindsey, Janet C, Swartz, Shanel, Morcavallo, Alaide, Gosling, Samantha Jepson, Singh, Mankaran, Blair, Helen J, Kohe, Sarah, Zhang, Tong, Maddocks, Oliver, Peet, Andrew, Chesler, Louis, Hickson, Ian, Maxwell, Ross, Hill, Rebecca M, Clifford, Steven C
Published in Neuro-oncology (Charlottesville, Va.) (18.06.2024)
Published in Neuro-oncology (Charlottesville, Va.) (18.06.2024)
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Exploring Pre-B Cell Receptor Signalling As a Therapeutic Target in Acute Lymphoblastic Leukaemia
Alhammer, Ali, Case, Marian, Blair, Helen J, Vormoor, Josef, Irving, Julie
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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