Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication
Burgess, Hannah M., Depledge, Daniel P., Thompson, Letitia, Srinivas, Kalanghad Puthankalam, Grande, Rebecca C., Vink, Elizabeth I., Abebe, Jonathan S., Blackaby, Wesley P., Hendrick, Alan, Albertella, Mark R., Kouzarides, Tony, Stapleford, Kenneth A., Wilson, Angus C., Mohr, Ian
Published in Genes & development (01.07.2021)
Published in Genes & development (01.07.2021)
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Discovery, Multiparametric Optimization, and Solid-State Driven Identification of CHF-6550, a Novel Soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases
Carzaniga, Laura, Linney, Ian D., Rizzi, Andrea, Schmidt, Wolfgang, Knight, Christopher K., Mileo, Valentina, Amadei, Francesco, Pastore, Fiorella, Miglietta, Daniela, Cesari, Nicola, Riccardi, Benedetta, Mazzucato, Roberta, Ghidini, Eleonora, Blackaby, Wesley P., Patacchini, Riccardo, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio
Published in Journal of medicinal chemistry (27.06.2024)
Published in Journal of medicinal chemistry (27.06.2024)
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Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and beta 2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD)
Rancati, Fabio, Linney, Ian D., Rizzi, Andrea, Delcanale, Maurizio, Knight, Chris K., Schmidt, Wolfgang, Pastore, Fiorella, Riccardi, Benedetta, Mileo, Valentina, Carnini, Chiara, Cesari, Nicola, Blackaby, Wesley P., Patacchini, Riccardo, Carzaniga, Laura
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
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Journal Article
Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD)
Rancati, Fabio, Linney, Ian D., Rizzi, Andrea, Delcanale, Maurizio, Knight, Chris K., Schmidt, Wolfgang, Pastore, Fiorella, Riccardi, Benedetta, Mileo, Valentina, Carnini, Chiara, Cesari, Nicola, Blackaby, Wesley P., Patacchini, Riccardo, Carzaniga, Laura
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
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Journal Article
Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases
Carzaniga, Laura, Linney, Ian D., Rizzi, Andrea, Delcanale, Maurizio, Schmidt, Wolfgang, Knight, Christopher K., Pastore, Fiorella, Miglietta, Daniela, Carnini, Chiara, Cesari, Nicola, Riccardi, Benedetta, Mileo, Valentina, Venturi, Luca, Moretti, Elisa, Blackaby, Wesley P., Patacchini, Riccardo, Accetta, Alessandro, Biagetti, Matteo, Bassani, Franco, Tondelli, Marina, Murgo, Annalisa, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio
Published in Journal of medicinal chemistry (11.08.2022)
Published in Journal of medicinal chemistry (11.08.2022)
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Journal Article
Targeting the m 6 A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication
Burgess, Hannah M, Depledge, Daniel P, Thompson, Letitia, Srinivas, Kalanghad Puthankalam, Grande, Rebecca C, Vink, Elizabeth I, Abebe, Jonathan S, Blackaby, Wesley P, Hendrick, Alan, Albertella, Mark R, Kouzarides, Tony, Stapleford, Kenneth A, Wilson, Angus C, Mohr, Ian
Published in Genes & development (01.07.2021)
Published in Genes & development (01.07.2021)
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Journal Article
Evaluation of 5‑(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington’s Disease
Stott, Andrew J, Maillard, Michel C, Beaumont, Vahri, Allcock, David, Aziz, Omar, Borchers, Alexander H, Blackaby, Wesley, Breccia, Perla, Creighton-Gutteridge, Gillian, Haughan, Alan F, Jarvis, Rebecca E, Luckhurst, Christopher A, Matthews, Kim L, McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Van de Poël, Amanda J, Vater, Huw D, Vann, Julie, Williams, Rachel, Yates, Dawn, Muñoz-Sanjuán, Ignacio, Dominguez, Celia
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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Imidazo[1,2-a]pyrimidines as Functionally Selective and Orally Bioavailable GABAAα2/α3 Binding Site Agonists for the Treatment of Anxiety Disorders
Goodacre, Simon C, Street, Leslie J, Hallett, David J, Crawforth, James M, Kelly, Sarah, Owens, Andrew P, Blackaby, Wesley P, Lewis, Richard T, Stanley, Joanna, Smith, Alison J, Ferris, Pushpinder, Sohal, Bindi, Cook, Susan M, Pike, Andrew, Brown, Nicola, Wafford, Keith A, Marshall, George, Castro, José L, Atack, John R
Published in Journal of medicinal chemistry (12.01.2006)
Published in Journal of medicinal chemistry (12.01.2006)
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Journal Article
Probing Mechanisms of CYP3A Time-Dependent Inhibition Using a Truncated Model System
Wang, Xiaojing, Sun, Minghua, New, Connie, Nam, Spencer, Blackaby, Wesley P, Hodges, Alastair J, Nash, David, Matteucci, Mizio, Lyssikatos, Joseph P, Fan, Peter W, Tay, Suzanne, Chang, Jae H
Published in ACS medicinal chemistry letters (13.08.2015)
Published in ACS medicinal chemistry letters (13.08.2015)
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Journal Article
Optimisation of a series of potent, selective and orally bioavailable GlyT1 inhibitors
Thomson, Joanne L., Blackaby, Wesley P., Jennings, Andrew S.R., Goodacre, Simon C., Pike, Andrew, Thomas, Steve, Brown, Terry A., Smith, Alison, Pillai, Gopalan, Street, Leslie J., Lewis, Richard T.
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
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Journal Article
Imidazo[1,2 -a]pyrimidines as functionally selective GABAA ligands
BLACKABY, Wesley P, ATACK, John R, STREET, Leslie J, TATTERSALL, David F. D, WAFFORD, Keith A, BROMIDGE, Frances, CASTRO, José L, GOODACRE, Simon C, HALLETT, David J, LEWIS, Richard T, MARSHALL, George R, PIKE, Andrew, SMITH, Alison J
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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Journal Article
Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1
Blackaby, Wesley P, Lewis, Richard T, Thomson, Joanne L, Jennings, Andrew S. R, Goodacre, Simon C, Street, Leslie J, MacLeod, Angus M, Pike, Andrew, Wood, Suzanne, Thomas, Steve, Brown, Terry A, Smith, Alison, Pillai, Gopalan, Almond, Sarah, Guscott, Martin R, Burns, H. Donald, Eng, Waisi, Ryan, Christine, Cook, Jacquelynn, Hamill, Terence G
Published in ACS medicinal chemistry letters (14.10.2010)
Published in ACS medicinal chemistry letters (14.10.2010)
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Journal Article
Imidazo[1,2- a]pyrimidines as functionally selective GABA A ligands
Blackaby, Wesley P., Atack, John R., Bromidge, Frances, Castro, José L., Goodacre, Simon C., Hallett, David J., Lewis, Richard T., Marshall, George R., Pike, Andrew, Smith, Alison J., Street, Leslie J., Tattersall, David F.D., Wafford, Keith A.
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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Journal Article
The in vivo properties of pagoclone in rat are most likely mediated by 5′-hydroxy pagoclone
Atack, John R., Pike, Andy, Marshall, George, Stanley, Jo, Lincoln, Rachael, Cook, Susan M., Lewis, Richard T., Blackaby, Wesley P., Goodacre, Simon C., McKernan, Ruth M., Dawson, Gerard R., Wafford, Keith A., Reynolds, David S.
Published in Neuropharmacology (01.05.2006)
Published in Neuropharmacology (01.05.2006)
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Journal Article
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia
Yankova, Eliza, Blackaby, Wesley, Albertella, Mark, Rak, Justyna, De Braekeleer, Etienne, Tsagkogeorga, Georgia, Pilka, Ewa S, Aspris, Demetrios, Leggate, Dan, Hendrick, Alan G, Webster, Natalie A, Andrews, Byron, Fosbeary, Richard, Guest, Patrick, Irigoyen, Nerea, Eleftheriou, Maria, Gozdecka, Malgorzata, Dias, Joao M L, Bannister, Andrew J, Vick, Binje, Jeremias, Irmela, Vassiliou, George S, Rausch, Oliver, Tzelepis, Konstantinos, Kouzarides, Tony
Published in Nature (London) (27.05.2021)
Published in Nature (London) (27.05.2021)
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Journal Article
Pyrazolopyridinones as functionally selective GABAA ligands
BLACKABY, Wesley P, ATACK, John R, BROMIDGE, Frances, LEWIS, Richard, RUSSELL, Michael G. N, SMITH, Alison, WAFFORD, Keith, MCKERNAN, Ruth M, STREET, Leslie J, CASTRO, José L
Published in Bioorganic & medicinal chemistry letters (15.11.2005)
Published in Bioorganic & medicinal chemistry letters (15.11.2005)
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Journal Article
Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington’s Disease Pathology
Macabuag, Natsuko, Esmieu, William, Breccia, Perla, Jarvis, Rebecca, Blackaby, Wesley, Lazari, Ovadia, Urbonas, Liudvikas, Eznarriaga, Maria, Williams, Rachel, Strijbosch, Annelieke, Van de Bospoort, Rhea, Matthews, Kim, Clissold, Cole, Ladduwahetty, Tammy, Vater, Huw, Heaphy, Patrick, Stafford, Douglas G., Wang, Hong-Jun, Mangette, John E., McAllister, George, Beaumont, Vahri, Vogt, Thomas F., Wilkinson, Hilary A., Doherty, Elizabeth M., Dominguez, Celia
Published in Journal of medicinal chemistry (22.09.2022)
Published in Journal of medicinal chemistry (22.09.2022)
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Journal Article
Discovery, Multiparametric Optimization, and Solid-State Driven Identification of CHF-6550, a Novel Soft Dual Pharmacology Muscarinic Antagonist and β 2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases
Carzaniga, Laura, Linney, Ian D., Rizzi, Andrea, Schmidt, Wolfgang, Knight, Christopher K., Mileo, Valentina, Amadei, Francesco, Pastore, Fiorella, Miglietta, Daniela, Cesari, Nicola, Riccardi, Benedetta, Mazzucato, Roberta, Ghidini, Eleonora, Blackaby, Wesley P., Patacchini, Riccardo, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio
Published in Journal of medicinal chemistry (27.06.2024)
Published in Journal of medicinal chemistry (27.06.2024)
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Journal Article
Optimization of M3 Antagonist–PDE4 Inhibitor (MAPI) Dual Pharmacology Molecules for the Treatment of COPD
Rizzi, Andrea, Amari, Gabriele, Pivetti, Fausto, Delcanale, Maurizio, Amadei, Francesco, Pappani, Alice, Fornasari, Luca, Villetti, Gino, Marchini, Gessica, Pisano, Anna Rita, Pitozzi, Vanessa, Pittelli, Maria Gloria, Trevisani, Marcello, Salvadori, Michela, Cenacchi, Valentina, Fioni, Alessandro, Puccini, Paola, Civelli, Maurizio, Patacchini, Riccardo, Baker-Glenn, Charles, Van de Poël, Hervé, Blackaby, Wesley, Nash, Kevin, Armani, Elisabetta
Published in Journal of medicinal chemistry (24.08.2023)
Published in Journal of medicinal chemistry (24.08.2023)
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Journal Article
Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and beta(2) Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases
Carzaniga, Laura, Linney, Ian D., Rizzi, Andrea, Delcanale, Maurizio, Schmidt, Wolfgang, Knight, Christopher K., Pastore, Fiorella, Miglietta, Daniela, Carnini, Chiara, Cesari, Nicola, Riccardi, Benedetta, Mileo, Valentina, Venturi, Luca, Moretti, Elisa, Blackaby, Wesley P., Patacchini, Riccardo, Accetta, Alessandro, Biagetti, Matteo, Bassani, Franco, Tondelli, Marina, Murgo, Annalisa, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio
Published in Journal of medicinal chemistry (11.08.2022)
Published in Journal of medicinal chemistry (11.08.2022)
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