Mesothelin-Targeted Thorium-227 Conjugate (MSLN-TTC): Preclinical Evaluation of a New Targeted Alpha Therapy for Mesothelin-Positive Cancers
Hagemann, Urs B, Ellingsen, Christine, Schuhmacher, Joachim, Kristian, Alexander, Mobergslien, Anne, Cruciani, Véronique, Wickstroem, Katrine, Schatz, Christoph A, Kneip, Christoph, Golfier, Sven, Smeets, Roger, Uran, Steinar, Hennekes, Hartwig, Karlsson, Jenny, Bjerke, Roger M, Ryan, Olav B, Mumberg, Dominik, Ziegelbauer, Karl, Cuthbertson, Alan S
Published in Clinical cancer research (01.08.2019)
Published in Clinical cancer research (01.08.2019)
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Journal Article
Synergistic Effect of a HER2 Targeted Thorium-227 Conjugate in Combination with Olaparib in a BRCA2 Deficient Xenograft Model
Wickstroem, Katrine, Karlsson, Jenny, Ellingsen, Christine, Cruciani, Véronique, Kristian, Alexander, Hagemann, Urs B, Bjerke, Roger M, Ryan, Olav B, Linden, Lars, Mumberg, Dominik, Brands, Michael, Cuthbertson, Alan
Published in Pharmaceuticals (Basel, Switzerland) (15.10.2019)
Published in Pharmaceuticals (Basel, Switzerland) (15.10.2019)
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Journal Article
Preclinical Efficacy of a PSMA-Targeted Thorium-227 Conjugate (PSMA-TTC), a Targeted Alpha Therapy for Prostate Cancer
Hammer, Stefanie, Hagemann, Urs B, Zitzmann-Kolbe, Sabine, Larsen, Aasmund, Ellingsen, Christine, Geraudie, Solene, Grant, Derek, Indrevoll, Baard, Smeets, Roger, von Ahsen, Oliver, Kristian, Alexander, Lejeune, Pascale, Hennekes, Hartwig, Karlsson, Jenny, Bjerke, Roger M, Ryan, Olav B, Cuthbertson, Alan S, Mumberg, Dominik
Published in Clinical cancer research (15.04.2020)
Published in Clinical cancer research (15.04.2020)
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Journal Article
In Vitro and In Vivo Efficacy of a Novel CD33-Targeted Thorium-227 Conjugate for the Treatment of Acute Myeloid Leukemia
Hagemann, Urs B, Wickstroem, Katrine, Wang, Ellen, Shea, Adam O, Sponheim, Kristine, Karlsson, Jenny, Bjerke, Roger M, Ryan, Olav B, Cuthbertson, Alan S
Published in Molecular cancer therapeutics (01.10.2016)
Published in Molecular cancer therapeutics (01.10.2016)
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Journal Article
Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met
Burggraaf, Jacobus, Kamerling, Ingrid M C, Gordon, Paul B, Schrier, Lenneke, de Kam, Marieke L, Kales, Andrea J, Bendiksen, Ragnar, Indrevoll, Bård, Bjerke, Roger M, Moestue, Siver A, Yazdanfar, Siavash, Langers, Alexandra M J, Swaerd-Nordmo, Marit, Torheim, Geir, Warren, Madhuri V, Morreau, Hans, Voorneveld, Philip W, Buckle, Tessa, van Leeuwen, Fijs W B, Ødegårdstuen, Liv-Ingrid, Dalsgaard, Grethe T, Healey, Andrew, Hardwick, James C H
Published in Nature medicine (01.08.2015)
Published in Nature medicine (01.08.2015)
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Journal Article
Advances in Precision Oncology: Targeted Thorium-227 Conjugates As a New Modality in Targeted Alpha Therapy
Hagemann, Urs B, Wickstroem, Katrine, Hammer, Stefanie, Bjerke, Roger M, Zitzmann-Kolbe, Sabine, Ryan, Olav B, Karlsson, Jenny, Scholz, Arne, Hennekes, Hartwig, Mumberg, Dominik, Cuthbertson, Alan S
Published in Cancer biotherapy & radiopharmaceuticals (01.09.2020)
Published in Cancer biotherapy & radiopharmaceuticals (01.09.2020)
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Journal Article
Preclinical efficacy of a PSMA-targeted actinium-225 conjugate (225Ac-macropa-pelgifatamab) - a targeted alpha therapy for prostate cancer
Schatz, Christoph A, Zitzmann-Kolbe, Sabine, Moen, Ingrid, Klotz, Monika, Nair, Shankari, Stargard, Stefan, Bjerke, Roger M, Wickstrøm Biseth, Katrine, Feng, Yuan Zeng, Indrevoll, Bård, Cruciani, Véronique, Karlsson, Jenny, Haendler, Bernard, Nielsen, Carsten H, Alfsen, Maria Z, Hammer, Stefanie, Hennekes, Hartwig, Cuthbertson, Alan, Hagemann, Urs B, Larsen, Aasmund
Published in Clinical cancer research (03.06.2024)
Published in Clinical cancer research (03.06.2024)
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Journal Article
A targeted thorium-227 conjugate demonstrates efficacy in preclinical models of acquired drug resistance and combination potential with chemotherapeutics and antiangiogenic therapies
Zitzmann-Kolbe, Sabine, Kristian, Alexander, Zopf, Dieter, Kamfenkel, Claudia, Politz, Oliver, Ellingsen, Christine, Hilbig, Jochen, Juul, Mark U, Fonslet, Jesper, Nielsen, Carsten H, Schatz, Christoph A, Bjerke, Roger M, Cuthbertson, Alan S, Mumberg, Dominik, Hagemann, Urs B
Published in Molecular cancer therapeutics (05.09.2023)
Published in Molecular cancer therapeutics (05.09.2023)
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Journal Article
Targeted alpha therapy using a novel CD70 targeted thorium-227 conjugate in in vitro and in vivo models of renal cell carcinoma
Hagemann, Urs B, Mihaylova, Dessislava, Uran, Steinar R, Borrebaek, Joergen, Grant, Derek, Bjerke, Roger M, Karlsson, Jenny, Cuthbertson, Alan S
Published in Oncotarget (22.08.2017)
Published in Oncotarget (22.08.2017)
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Journal Article
An efficient chelator for complexation of thorium-227
Ramdahl, Thomas, Bonge-Hansen, Hanne T., Ryan, Olav B., Larsen, Åsmund, Herstad, Gunnar, Sandberg, Marcel, Bjerke, Roger M., Grant, Derek, Brevik, Ellen M., Cuthbertson, Alan S.
Published in Bioorganic & medicinal chemistry letters (01.09.2016)
Published in Bioorganic & medicinal chemistry letters (01.09.2016)
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Journal Article
Preclinical Combination Studies of an FGFR2 Targeted Thorium-227 Conjugate and the ATR Inhibitor BAY 1895344
Wickstroem, Katrine, Hagemann, Urs B., Kristian, Alexander, Ellingsen, Christine, Sommer, Anette, Ellinger-Ziegelbauer, Heidrun, Wirnitzer, Uta, Hagelin, Else-Marie, Larsen, Aasmund, Smeets, Roger, Bjerke, Roger M., Karlsson, Jenny, Ryan, Olav B., Wengner, Antje M., Linden, Lars, Mumberg, Dominik, Cuthbertson, Alan S.
Published in International journal of radiation oncology, biology, physics (01.10.2019)
Published in International journal of radiation oncology, biology, physics (01.10.2019)
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Journal Article
Efficacy of a HER2-Targeted Thorium-227 Conjugate in a HER2-Positive Breast Cancer Bone Metastasis Model
Karlsson, Jenny, Hagemann, Urs B, Cruciani, Véronique, Schatz, Christoph A, Grant, Derek, Ellingsen, Christine, Kristian, Alexander, Katoozi, Shirin, Mihaylova, Dessislava, Uran, Steinar R, Suominen, Mari, Bjerke, Roger M, Ryan, Olav B, Cuthbertson, Alan
Published in Cancers (29.06.2023)
Published in Cancers (29.06.2023)
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Journal Article
Synergistic Effect of a Mesothelin-Targeted 227Th Conjugate in Combination with DNA Damage Response Inhibitors in Ovarian Cancer Xenograft Models
Wickstroem, Katrine, Hagemann, Urs B, Cruciani, Véronique, Wengner, Antje M, Kristian, Alexander, Ellingsen, Christine, Siemeister, Gerhard, Bjerke, Roger M, Karlsson, Jenny, Ryan, Olav B, Linden, Lars, Mumberg, Dominik, Ziegelbauer, Karl, Cuthbertson, Alan S
Published in The Journal of nuclear medicine (1978) (01.09.2019)
Published in The Journal of nuclear medicine (1978) (01.09.2019)
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Journal Article
Synergistic Effect of a Mesothelin-Targeted 227 Th Conjugate in Combination with DNA Damage Response Inhibitors in Ovarian Cancer Xenograft Models
Wickstroem, Katrine, Hagemann, Urs B, Cruciani, Véronique, Wengner, Antje M, Kristian, Alexander, Ellingsen, Christine, Siemeister, Gerhard, Bjerke, Roger M, Karlsson, Jenny, Ryan, Olav B, Linden, Lars, Mumberg, Dominik, Ziegelbauer, Karl, Cuthbertson, Alan S
Published in Journal of Nuclear Medicine (01.09.2019)
Published in Journal of Nuclear Medicine (01.09.2019)
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Journal Article
Abstract 640: New models of breast and lung cancer bone metastases for preclinical efficacy testing
Suominen, Mari I., Hagemann, Urs B., Konkol, Yvonne, Bernoulli, Jenni, Fagerlund, Katja M., Bjerke, Roger M., Karlsson, Jenny, Halleen, Jussi M., Cuthbertson, Alan
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Identification of the Protein Target of Myelin-Binding Ligands by Immunohistochemistry and Biochemical Analyses
Bajaj, Anshika, LaPlante, Nicole E., Cotero, Victoria E., Fish, Kenneth M., Bjerke, Roger M., Siclovan, Tiberiu, Tan Hehir, Cristina A.
Published in The journal of histochemistry and cytochemistry (01.01.2013)
Published in The journal of histochemistry and cytochemistry (01.01.2013)
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Journal Article
Abstract 591: A novel high energy alpha-pharmaceutical: In vitro and in vivo potency of a mesothelin-targeted thorium-227 conjugate (TTC) in a model of bone disease
Hagemann, Urs B., Hagelin, Else-Marie, Wickstroem, Katrine, Sponheim, Kristine, Smeets, Roger, Karlsson, Jenny, Bjerke, Roger M., Suominen, Mari I., Konkol, Yvonne, Bernoulli, Jenni, Rissanen, Jukka, Halleen, Jussi, Oedegaardstuen, Liv-Ingrid, Cuthbertson, Alan
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 3937: MSLN-TTC (BAY 2287411) demonstrates increased activity in comparison to standard of care chemotherapy in models of acquired drug resistance
Hagemann, Urs B., Zitzmann-Kolbe, Sabine, Kristian, Alexander, Sperl, Carolyn, Schatz, Christoph A., Bjerke, Roger M., Cuthbertson, Alan S., Hennekes, Hartwig, Ziegelbauer, Karl, Mumberg, Dominik
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 2257: Targeted thorium-227 conjugates demonstrate synergistic activity in combination with PD-L1 inhibitors
Hagemann, Urs B., Lejeune, Pascale, Bartnitzky, Lisa, Stadelmann, Kathleen, Cruciani, Veronique, Bjerke, Roger M., Berndt, Sandra, Kamfenkel, Claudia, Brand, Manuela, Steinbach, Manuela, Stargard, Stefan, Schatz, Christoph A., Karlsson, Jenny, Hennekes, Hartwig, Cuthbertson, Alan S., Mumberg, Dominik
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 3726: Preclinical activity of PSMA-TTC (BAY 2315497) in combination with androgen receptor antagonists in prostate cancer models
Hammer, Stefanie, Hagemann, Urs B., Zitzmann-Kolbe, Sabine, Larsen, Aasmund, Ellingsen, Chrstine, Ahsen, Oliver von, Karlsson, Jenny, Bjerke, Roger M., Ryan, Olav B., Lejeune, Pascale, Hennekes, Hartwig, Cuthbertson, Alan, Mumberg, Dominik
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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