The Drug Repurposing Hub: a next-generation drug library and information resource
Corsello, Steven M, Bittker, Joshua A, Liu, Zihan, Gould, Joshua, McCarren, Patrick, Hirschman, Jodi E, Johnston, Stephen E, Vrcic, Anita, Wong, Bang, Khan, Mariya, Asiedu, Jacob, Narayan, Rajiv, Mader, Christopher C, Subramanian, Aravind, Golub, Todd R
Published in Nature medicine (07.04.2017)
Published in Nature medicine (07.04.2017)
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Journal Article
Genetic and transcriptional evolution alters cancer cell line drug response
Ben-David, Uri, Siranosian, Benjamin, Ha, Gavin, Tang, Helen, Oren, Yaara, Hinohara, Kunihiko, Strathdee, Craig A., Dempster, Joshua, Lyons, Nicholas J., Burns, Robert, Nag, Anwesha, Kugener, Guillaume, Cimini, Beth, Tsvetkov, Peter, Maruvka, Yosef E., O’Rourke, Ryan, Garrity, Anthony, Tubelli, Andrew A., Bandopadhayay, Pratiti, Tsherniak, Aviad, Vazquez, Francisca, Wong, Bang, Birger, Chet, Ghandi, Mahmoud, Thorner, Aaron R., Bittker, Joshua A., Meyerson, Matthew, Getz, Gad, Beroukhim, Rameen, Golub, Todd R.
Published in Nature (London) (01.08.2018)
Published in Nature (London) (01.08.2018)
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Journal Article
Correlating chemical sensitivity and basal gene expression reveals mechanism of action
Rees, Matthew G, Seashore-Ludlow, Brinton, Cheah, Jaime H, Adams, Drew J, Price, Edmund V, Gill, Shubhroz, Javaid, Sarah, Coletti, Matthew E, Jones, Victor L, Bodycombe, Nicole E, Soule, Christian K, Alexander, Benjamin, Li, Ava, Montgomery, Philip, Kotz, Joanne D, Hon, C Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Haber, Daniel A, Clish, Clary B, Bittker, Joshua A, Palmer, Michelle, Wagner, Bridget K, Clemons, Paul A, Shamji, Alykhan F, Schreiber, Stuart L
Published in Nature chemical biology (01.02.2016)
Published in Nature chemical biology (01.02.2016)
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Journal Article
An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules
Basu, Amrita, Bodycombe, Nicole E., Cheah, Jaime H., Price, Edmund V., Liu, Ke, Schaefer, Giannina I., Ebright, Richard Y., Stewart, Michelle L., Ito, Daisuke, Wang, Stephanie, Bracha, Abigail L., Liefeld, Ted, Wawer, Mathias, Gilbert, Joshua C., Wilson, Andrew J., Stransky, Nicolas, Kryukov, Gregory V., Dancik, Vlado, Barretina, Jordi, Garraway, Levi A., Hon, C. Suk-Yee, Munoz, Benito, Bittker, Joshua A., Stockwell, Brent R., Khabele, Dineo, Stern, Andrew M., Clemons, Paul A., Shamji, Alykhan F., Schreiber, Stuart L.
Published in Cell (29.08.2013)
Published in Cell (29.08.2013)
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Journal Article
Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset
Seashore-Ludlow, Brinton, Rees, Matthew G, Cheah, Jaime H, Cokol, Murat, Price, Edmund V, Coletti, Matthew E, Jones, Victor, Bodycombe, Nicole E, Soule, Christian K, Gould, Joshua, Alexander, Benjamin, Li, Ava, Montgomery, Philip, Wawer, Mathias J, Kuru, Nurdan, Kotz, Joanne D, Hon, C Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Bittker, Joshua A, Palmer, Michelle, Bradner, James E, Shamji, Alykhan F, Clemons, Paul A, Schreiber, Stuart L
Published in Cancer discovery (01.11.2015)
Published in Cancer discovery (01.11.2015)
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Journal Article
Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes
Sharabi, Kfir, Lin, Hua, Tavares, Clint D.J., Dominy, John E., Camporez, Joao Paulo, Perry, Rachel J., Schilling, Roger, Rines, Amy K., Lee, Jaemin, Hickey, Marc, Bennion, Melissa, Palmer, Michelle, Nag, Partha P., Bittker, Joshua A., Perez, José, Jedrychowski, Mark P., Ozcan, Umut, Gygi, Steve P., Kamenecka, Theodore M., Shulman, Gerald I., Schreiber, Stuart L., Griffin, Patrick R., Puigserver, Pere
Published in Cell (23.03.2017)
Published in Cell (23.03.2017)
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Journal Article
Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling
Corsello, Steven M, Nagari, Rohith T, Spangler, Ryan D, Rossen, Jordan, Kocak, Mustafa, Bryan, Jordan G, Humeidi, Ranad, Peck, David, Wu, Xiaoyun, Tang, Andrew A, Wang, Vickie M, Bender, Samantha A, Lemire, Evan, Narayan, Rajiv, Montgomery, Philip, Ben-David, Uri, Garvie, Colin W, Chen, Yejia, Rees, Matthew G, Lyons, Nicholas J, McFarland, James M, Wong, Bang T, Wang, Li, Dumont, Nancy, O'Hearn, Patrick J, Stefan, Eric, Doench, John G, Harrington, Caitlin N, Greulich, Heidi, Meyerson, Matthew, Vazquez, Francisca, Subramanian, Aravind, Roth, Jennifer A, Bittker, Joshua A, Boehm, Jesse S, Mader, Christopher C, Tsherniak, Aviad, Golub, Todd R
Published in Nature cancer (01.02.2020)
Published in Nature cancer (01.02.2020)
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Journal Article
Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling
Wawer, Mathias J., Li, Kejie, Gustafsdottir, Sigrun M., Ljos, Vebjorn, Bodycombe, Nicole E., Marton, Melissa A., Sokolnicki, Katherine L., Bray, Mark-Anthony, Kemp, Melissa M., Winchester, Ellen, Taylor, Bradley, Grant, George B., Hon, C. Suk-Yee, Duvall, Jeremy R., Wilson, J. Anthony, Bittker, Joshua A., Dančík, Vlado, Narayan, Rajiv, Subramanian, Aravind, Winckler, Wendy, Golub, Todd R., Carpenter, Anne E., Shamji, Alykhan F., Schreiber, Stuart L., Clemons, Paul A.
Published in Proceedings of the National Academy of Sciences - PNAS (29.07.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (29.07.2014)
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Journal Article
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
Kato, Nobutaka, Comer, Eamon, Sakata-Kato, Tomoyo, Sharma, Arvind, Sharma, Manmohan, Maetani, Micah, Bastien, Jessica, Brancucci, Nicolas M., Bittker, Joshua A., Corey, Victoria, Clarke, David, Derbyshire, Emily R., Dornan, Gillian L., Duffy, Sandra, Eckley, Sean, Itoe, Maurice A., Koolen, Karin M. J., Lewis, Timothy A., Lui, Ping S., Lukens, Amanda K., Lund, Emily, March, Sandra, Meibalan, Elamaran, Meier, Bennett C., McPhail, Jacob A., Mitasev, Branko, Moss, Eli L., Sayes, Morgane, Van Gessel, Yvonne, Wawer, Mathias J., Yoshinaga, Takashi, Zeeman, Anne-Marie, Avery, Vicky M., Bhatia, Sangeeta N., Burke, John E., Catteruccia, Flaminia, Clardy, Jon C., Clemons, Paul A., Dechering, Koen J., Duvall, Jeremy R., Foley, Michael A., Gusovsky, Fabian, Kocken, Clemens H. M., Marti, Matthias, Morningstar, Marshall L., Munoz, Benito, Neafsey, Daniel E., Sharma, Amit, Winzeler, Elizabeth A., Wirth, Dyann F., Scherer, Christina A., Schreiber, Stuart L.
Published in Nature (London) (20.10.2016)
Published in Nature (London) (20.10.2016)
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Journal Article
A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay
Bray, Mark-Anthony, Gustafsdottir, Sigrun M, Rohban, Mohammad H, Singh, Shantanu, Ljosa, Vebjorn, Sokolnicki, Katherine L, Bittker, Joshua A, Bodycombe, Nicole E, Dančík, Vlado, Hasaka, Thomas P, Hon, Cindy S, Kemp, Melissa M, Li, Kejie, Walpita, Deepika, Wawer, Mathias J, Golub, Todd R, Schreiber, Stuart L, Clemons, Paul A, Shamji, Alykhan F, Carpenter, Anne E
Published in Gigascience (01.12.2017)
Published in Gigascience (01.12.2017)
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Journal Article
High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl‑2 Binding
Chiang, Wei-Chung, Wei, Yongjie, Kuo, Yi-Chun, Wei, Shuguang, Zhou, Anwu, Zou, Zhongju, Yehl, Jenna, Ranaghan, Matthew J, Skepner, Adam, Bittker, Joshua A, Perez, Jose R, Posner, Bruce A, Levine, Beth
Published in ACS chemical biology (17.08.2018)
Published in ACS chemical biology (17.08.2018)
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Journal Article
Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease
Leshchiner, Elizaveta S., Rush, Jason S., Durney, Michael A., Cao, Zhifang, Dančík, Vlado, Chittick, Benjamin, Wu, Huixian, Petrone, Adam, Bittker, Joshua A., Phillips, Andrew, Perez, Jose R., Shamji, Alykhan F., Kaushik, Virendar K., Daly, Mark J., Graham, Daniel B., Schreiber, Stuart L., Xavier, Ramnik J.
Published in Proceedings of the National Academy of Sciences - PNAS (24.10.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (24.10.2017)
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Journal Article
Development of small-molecule probes that selectively kill cells induced to express mutant RAS
Weïwer, Michel, Bittker, Joshua A., Lewis, Timothy A., Shimada, Kenichi, Yang, Wan Seok, MacPherson, Lawrence, Dandapani, Sivaraman, Palmer, Michelle, Stockwell, Brent R., Schreiber, Stuart L., Munoz, Benito
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells
Hartwell, Kimberly A, Miller, Peter G, Mukherjee, Siddhartha, Kahn, Alissa R, Stewart, Alison L, Logan, David J, Negri, Joseph M, Duvet, Mildred, Järås, Marcus, Puram, Rishi, Dancik, Vlado, Al-Shahrour, Fatima, Kindler, Thomas, Tothova, Zuzana, Chattopadhyay, Shrikanta, Hasaka, Thomas, Narayan, Rajiv, Dai, Mingji, Huang, Christina, Shterental, Sebastian, Chu, Lisa P, Haydu, J Erika, Shieh, Jae Hung, Steensma, David P, Munoz, Benito, Bittker, Joshua A, Shamji, Alykhan F, Clemons, Paul A, Tolliday, Nicola J, Carpenter, Anne E, Gilliland, D Gary, Stern, Andrew M, Moore, Malcolm A S, Scadden, David T, Schreiber, Stuart L, Ebert, Benjamin L, Golub, Todd R
Published in Nature chemical biology (01.12.2013)
Published in Nature chemical biology (01.12.2013)
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Journal Article
Small-molecule inducers of insulin expression in pancreatic α-cells
Fomina-Yadlin, Dina, Kubicek, Stefan, Walpita, Deepika, Dančik, Vlado, Hecksher-Sørensen, Jacob, Bittker, Joshua A, Sharifnia, Tanaz, Shamji, Alykhan, Clemons, Paul A, Wagner, Bridget K, Schreiber, Stuart L
Published in Proceedings of the National Academy of Sciences - PNAS (24.08.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (24.08.2010)
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Journal Article
Evolving BioAssay Ontology (BAO): modularization, integration and applications
Abeyruwan, Saminda, Vempati, Uma D, Küçük-McGinty, Hande, Visser, Ubbo, Koleti, Amar, Mir, Ahsan, Sakurai, Kunie, Chung, Caty, Bittker, Joshua A, Clemons, Paul A, Brudz, Steve, Siripala, Anosha, Morales, Arturo J, Romacker, Martin, Twomey, David, Bureeva, Svetlana, Lemmon, Vance, Schürer, Stephan C
Published in Journal of biomedical semantics (2014)
Published in Journal of biomedical semantics (2014)
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Journal Article
The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes
Clemons, Paul A., Bittker, Joshua A., Wagner, Florence F., Hands, Allison, Dančík, Vlado, Schreiber, Stuart L., Choudhary, Amit, Wagner, Bridget K.
Published in SLAS discovery (01.08.2021)
Published in SLAS discovery (01.08.2021)
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Journal Article
Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles
Youngsaye, Willmen, Dockendorff, Chris, Vincent, Benjamin, Hartland, Cathy L., Bittker, Joshua A., Dandapani, Sivaraman, Palmer, Michelle, Whitesell, Luke, Lindquist, Susan, Schreiber, Stuart L., Munoz, Benito
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
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Journal Article
High Throughput Screen Identifies Interferon γ‑Dependent Inhibitors of Toxoplasma gondii Growth
Radke, Joshua B., Carey, Kimberly L., Shaw, Subrata, Metkar, Shailesh R., Mulrooney, Carol, Gale, Jennifer P., Bittker, Joshua A., Hilgraf, Robert, Comer, Eamon, Schreiber, Stuart L., Virgin, Herbert W., Perez, Jose R., Sibley, L. David
Published in ACS infectious diseases (12.10.2018)
Published in ACS infectious diseases (12.10.2018)
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Journal Article
Enhancing the rate of scaffold discovery with diversity-oriented prioritization
Swamidass, S. Joshua, Calhoun, Bradley T., Bittker, Joshua A., Bodycombe, Nicole E., Clemons, Paul A.
Published in Bioinformatics (15.08.2011)
Published in Bioinformatics (15.08.2011)
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