TLR9 dependent activation by inactivated parapoxvirus ovis (iPPVO) in murine bone marrow-derived dendritic cells is associated with specific strain-dependent dendritic cell subsets
Du, Yanqin, Sun, Hang, Bhattacharjee, Sonakshi, Birkmann, Alexander, Dittmer, Ulf, Lu, Mengji
Published in Journal of innate immunity (08.06.2024)
Published in Journal of innate immunity (08.06.2024)
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Journal Article
Helicase–Primase Inhibitor Pritelivir for HSV-2 Infection
Wald, Anna, Corey, Lawrence, Timmler, Burkhard, Magaret, Amalia, Warren, Terri, Tyring, Stephen, Johnston, Christine, Kriesel, John, Fife, Kenneth, Galitz, Lawrence, Stoelben, Susanne, Huang, Meei-Li, Selke, Stacy, Stobernack, Hans-Peter, Ruebsamen-Schaeff, Helga, Birkmann, Alexander
Published in The New England journal of medicine (16.01.2014)
Published in The New England journal of medicine (16.01.2014)
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Journal Article
Kaposi's Sarcoma-Associated Herpesvirus gH/gL: Glycoprotein Export and Interaction with Cellular Receptors
HAHN, Alexander, BIRKMANN, Alexander, WIES, Effi, DORER, Dominik, MAHR, Kerstin, STÜRZL, Michael, TITGEMEYER, Fritz, NEIPEL, Frank
Published in Journal of Virology (01.01.2009)
Published in Journal of Virology (01.01.2009)
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Journal Article
Cell Surface Heparan Sulfate Is a Receptor for Human Herpesvirus 8 and Interacts with Envelope Glycoprotein K8.1
Birkmann, Alexander, Mahr, Kerstin, Ensser, Armin, Yağuboğlu, Svenja, Titgemeyer, Fritz, Fleckenstein, Bernhard, Neipel, Frank
Published in Journal of Virology (01.12.2001)
Published in Journal of Virology (01.12.2001)
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Journal Article
The product of the SNF2/SWI2 paralogue INO80 of Saccharomyces cerevisiae required for efficient expression of various yeast structural genes is part of a high‐molecular‐weight protein complex
Ebbert, Ronald, Birkmann, Alexander, Schüller, Hans‐Joachim
Published in Molecular microbiology (01.05.1999)
Published in Molecular microbiology (01.05.1999)
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Journal Article
The Immunogenic Glycoprotein gp35-37 of Human Herpesvirus 8 Is Encoded by Open Reading Frame K8.1
Raab, Marc-Steffen, Albrecht, Jens-Christian, Birkmann, Alexander, Yağuboğlu, Svenja, Lang, Dieter, Fleckenstein, Bernhard, Neipel, Frank
Published in Journal of Virology (01.08.1998)
Published in Journal of Virology (01.08.1998)
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Journal Article
Discovery, Chemistry, and Preclinical Development of Pritelivir, a Novel Treatment Option for Acyclovir-Resistant Herpes Simplex Virus Infections
Birkmann, Alexander, Bonsmann, Susanne, Kropeit, Dirk, Pfaff, Tamara, Rangaraju, Manickam, Sumner, Melanie, Timmler, Burkhard, Zimmermann, Holger, Buschmann, Helmut, Ruebsamen-Schaeff, Helga
Published in Journal of medicinal chemistry (27.10.2022)
Published in Journal of medicinal chemistry (27.10.2022)
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Journal Article
Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences: A Randomized Clinical Trial
Wald, Anna, Timmler, Burkhard, Magaret, Amalia, Warren, Terri, Tyring, Stephen, Johnston, Christine, Fife, Kenneth, Selke, Stacy, Huang, Meei-Li, Stobernack, Hans-Peter, Zimmermann, Holger, Corey, Lawrence, Birkmann, Alexander, Ruebsamen-Schaeff, Helga
Published in JAMA : the journal of the American Medical Association (20.12.2016)
Published in JAMA : the journal of the American Medical Association (20.12.2016)
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Journal Article
Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action
Carta, Fabrizio, Birkmann, Alexander, Pfaff, Tamara, Buschmann, Helmut, Schwab, Wilfried, Zimmermann, Holger, Maresca, Alfonso, Supuran, Claudiu T.
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Journal Article
코로나바이러스 감염에 대한 조건화 및 코로나바이러스 감염의 치료를 위한 파라폭스바이러스
PFAFF TAMARA, PAULSEN DANIELA, LISCHKA PETER, BIRKMANN ALEXANDER, ZIMMERMANN HOLGER
Year of Publication 16.01.2023
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Year of Publication 16.01.2023
Patent
Evaluation of the Clinical Drug‐Drug Interaction Potential of Pritelivir on Transporters and CYP450 Enzymes Using a Cocktail Approach
Vries, Michiel, Bonsmann, Susanne, Pausch, Jörg, Sumner, Melanie, Birkmann, Alexander, Zimmermann, Holger, Kropeit, Dirk
Published in Clinical pharmacology in drug development (01.07.2024)
Published in Clinical pharmacology in drug development (01.07.2024)
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Journal Article
Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis
Quenelle, Debra C., Birkmann, Alexander, Goldner, Thomas, Pfaff, Tamara, Zimmermann, Holger, Bonsmann, Susanne, Collins, Deborah J., Rice, Terri L., Prichard, Mark N.
Published in Antiviral research (01.01.2018)
Published in Antiviral research (01.01.2018)
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Journal Article
Mass Balance and Metabolite Profile after Single and Multiple Oral Doses of Pritelivir in Healthy Subjects
Bonsmann, Susanne, McCormick, David, Pausch, Jörg, Vries, Michiel, Sumner, Melanie, Birkmann, Alexander, Zimmermann, Holger, Kropeit, Dirk
Published in Clinical pharmacology in drug development (01.04.2024)
Published in Clinical pharmacology in drug development (01.04.2024)
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Journal Article
Effect of Renal and Hepatic Impairment on the Pharmacokinetics of Pritelivir and Its Metabolites
Erb‐Zohar, Katharina, Bonsmann, Susanne, Pausch, Jörg, Sumner, Melanie, Birkmann, Alexander, Zimmermann, Holger, Halabi, Atef, Kropeit, Dirk
Published in Clinical pharmacology in drug development (01.11.2024)
Published in Clinical pharmacology in drug development (01.11.2024)
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Journal Article
First‐in‐Human, Single‐ and Multiple‐Ascending‐Dose, Food‐Effect, and Absolute Bioavailability Trials to Assess the Pharmacokinetics, Safety, and Tolerability of Pritelivir, a Nonnucleoside Helicase‐Primase Inhibitor Against Herpes Simplex Virus in Healthy Subjects
Kropeit, Dirk, Bonsmann, Susanne, Richter, Oliver, McCormick, David, Pausch, Jörg, Sumner, Melanie, Birkmann, Alexander, Zimmermann, Holger, Rübsamen‐Schaeff, Helga
Published in Clinical pharmacology in drug development (01.07.2023)
Published in Clinical pharmacology in drug development (01.07.2023)
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Journal Article
Baseline sensitivity of HSV-1 and HSV-2 clinical isolates and defined acyclovir-resistant strains to the helicase–primase inhibitor pritelivir
Field, Hugh J., Huang, Meei-Li, Lay, Elizabeth M., Mickleburgh, Ian, Zimmermann, Holger, Birkmann, Alexander
Published in Antiviral research (01.11.2013)
Published in Antiviral research (01.11.2013)
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Journal Article
Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro
Corcuera, Angelica, Stolle, Katharina, Hillmer, Stefan, Seitz, Stefan, Lee, Ji-Young, Bartenschlager, Ralf, Birkmann, Alexander, Urban, Andreas
Published in Antiviral research (01.10.2018)
Published in Antiviral research (01.10.2018)
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Journal Article
Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes
Schiffer, Joshua T, Swan, David A, Magaret, Amalia, Corey, Lawrence, Wald, Anna, Ossig, Joachim, Ruebsamen-Schaeff, Helga, Stoelben, Susanne, Timmler, Burkhard, Zimmermann, Holger, Melhem, Murad R, Van Wart, Scott A, Rubino, Christopher M, Birkmann, Alexander
Published in Science translational medicine (03.02.2016)
Published in Science translational medicine (03.02.2016)
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