Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer
Gross, Matt I, Demo, Susan D, Dennison, Jennifer B, Chen, Lijing, Chernov-Rogan, Tania, Goyal, Bindu, Janes, Julie R, Laidig, Guy J, Lewis, Evan R, Li, Jim, Mackinnon, Andrew L, Parlati, Francesco, Rodriguez, Mirna L M, Shwonek, Peter J, Sjogren, Eric B, Stanton, Timothy F, Wang, Taotao, Yang, Jinfu, Zhao, Frances, Bennett, Mark K
Published in Molecular cancer therapeutics (01.04.2014)
Published in Molecular cancer therapeutics (01.04.2014)
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Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine C‑Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV
Mackman, Richard L, Hui, Hon C, Perron, Michel, Murakami, Eisuke, Palmiotti, Christopher, Lee, Gary, Stray, Kirsten, Zhang, Lijun, Goyal, Bindu, Chun, Kwon, Byun, Daniel, Siegel, Dustin, Simonovich, Scott, Du Pont, Venice, Pitts, Jared, Babusis, Darius, Vijjapurapu, Arya, Lu, Xianghan, Kim, Cynthia, Zhao, Xiaofeng, Chan, Julie, Ma, Bin, Lye, Diane, Vandersteen, Adelle, Wortman, Sarah, Barrett, Kimberly T, Toteva, Maria, Jordan, Robert, Subramanian, Raju, Bilello, John P, Cihlar, Tomas
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Discovery of GS-7682, a Novel 4′-Cyano-Modified C‑Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys
Siegel, Dustin S., Hui, Hon C., Pitts, Jared, Vermillion, Meghan S., Ishida, Kazuya, Rautiola, Davin, Keeney, Michael, Irshad, Hammad, Zhang, Lijun, Chun, Kwon, Chin, Gregory, Goyal, Bindu, Doerffler, Edward, Yang, Hai, Clarke, Michael O., Palmiotti, Chris, Vijjapurapu, Arya, Riola, Nicholas C., Stray, Kirsten, Murakami, Eisuke, Ma, Bin, Wang, Ting, Zhao, Xiaofeng, Xu, Yili, Lee, Gary, Marchand, Bruno, Seung, Minji, Nayak, Arabinda, Tomkinson, Adrian, Kadrichu, Nani, Ellis, Scott, Barauskas, Ona, Feng, Joy Y., Perry, Jason K., Perron, Michel, Bilello, John P., Kuehl, Philip J., Subramanian, Raju, Cihlar, Tomas, Mackman, Richard L.
Published in Journal of medicinal chemistry (08.08.2024)
Published in Journal of medicinal chemistry (08.08.2024)
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ANTIVIRAL COMPOUNDS
MICHAEL R MISH, GREGORY F CHIN, BINDU GOYAL, PETR JANSA, MACKMAN RICHARD L, DANIEL H BYUN, DUSTIN S SIEGEL, MICHAEL O CLARKE
Year of Publication 02.04.2024
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Year of Publication 02.04.2024
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ANTIVIRAL COMPOUNDS
CHUN BYOUNG-KWON, GREGORY F CHIN, BINDU GOYAL, HON C HUI, PETR JANSA, MACKMAN RICHARD L, DUSTIN S SIEGEL, YANG HAI, MICHAEL O CLARKE
Year of Publication 01.02.2024
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Year of Publication 01.02.2024
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Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition
Safina, Brian S, Baker, Stewart, Baumgardner, Matt, Blaney, Paul M, Chan, Bryan K, Chen, Yung-Hsiang, Cartwright, Matthew W, Castanedo, Georgette, Chabot, Christine, Cheguillaume, Arnaud J, Goldsmith, Paul, Goldstein, David M, Goyal, Bindu, Hancox, Timothy, Handa, Raj K, Iyer, Pravin S, Kaur, Jasmit, Kondru, Rama, Kenny, Jane R, Krintel, Sussie L, Li, Jun, Lesnick, John, Lucas, Matthew C, Lewis, Cristina, Mukadam, Sophie, Murray, Jeremy, Nadin, Alan J, Nonomiya, Jim, Padilla, Fernando, Palmer, Wylie S, Pang, Jodie, Pegg, Neil, Price, Steve, Reif, Karin, Salphati, Laurent, Savy, Pascal A, Seward, Eileen M, Shuttleworth, Stephen, Sohal, Sukhjit, Sweeney, Zachary K, Tay, Suzanne, Tivitmahaisoon, Parcharee, Waszkowycz, Bohdan, Wei, Binqing, Yue, Qin, Zhang, Chenghong, Sutherlin, Daniel P
Published in Journal of medicinal chemistry (28.06.2012)
Published in Journal of medicinal chemistry (28.06.2012)
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Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): Optimization for JNK potency and physicochemical properties
Gong, Leyi, Han, Xiaochun, Silva, Tania, Tan, Yun-Chou, Goyal, Bindu, Tivitmahaisoon, Parch, Trejo, Alejandra, Palmer, Wylie, Hogg, Heather, Jahagir, Alam, Alam, Muzaffar, Wagner, Paul, Stein, Karin, Filonova, Lubov, Loe, Brad, Makra, Ferenc, Rotstein, David, Rapatova, Lubica, Dunn, James, Zuo, Fengrong, Porto, Joseph Dal, Wong, Brian, Jin, Sue, Chang, Alice, Tran, Patricia, Hsieh, Gary, Niu, Linghao, Shao, Ada, Reuter, Deborah, Hermann, Johaness, Kuglstatter, Andreas, Goldstein, David
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
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Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): Kinase profiling guided optimization of a 1,2,3-benzotriazole lead
Palmer, Wylie S., Alam, Muzaffar, Arzeno, Humberto B., Chang, Kung-Ching, Dunn, James P., Goldstein, David M., Gong, Leyi, Goyal, Bindu, Hermann, Johannes C., Hogg, J. Heather, Hsieh, Gary, Jahangir, Alam, Janson, Cheryl, Jin, Sue, Ursula Kammlott, R., Kuglstatter, Andreas, Lukacs, Christine, Michoud, Christophe, Niu, Linghao, Reuter, Deborah C., Shao, Ada, Silva, Tania, Trejo-Martin, Teresa A., Stein, Karin, Tan, Yun-Chou, Tivitmahaisoon, Parcharee, Tran, Patricia, Wagner, Paul, Weller, Paul, Wu, Shao-Yong
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
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Novel pyrrolo[2,1- f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinases
Fink, Brian E., Norris, Derek, Mastalerz, Harold, Chen, Ping, Goyal, Bindu, Zhao, Yufen, Kim, Soong-Hoon, Vite, Gregory D., Lee, Francis Y., Zhang, Hongjian, Oppenheimer, Simone, Tokarski, John S., Wong, Tai W., Gavai, Ashvinikumar V.
Published in Bioorganic & medicinal chemistry letters (15.01.2011)
Published in Bioorganic & medicinal chemistry letters (15.01.2011)
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HETEROCYCLIC INHIBITORS OF GLUTAMINASE
GUY LAIDIG, BINDU GOYAL, ERIC BRIAN SJOGREN, CHEN LI-JING, TIMOTHY FRIEND STANTON, JIM LI
Year of Publication 19.07.2018
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Year of Publication 19.07.2018
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Discovery and Preclinical Evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic Acid, (3S)-3-Morpholinylmethyl Ester (BMS-599626), a Selective and Orally Efficacious Inhibitor of Human Epidermal Growth Factor Receptor 1 and 2 Kinases
Gavai, Ashvinikumar V, Fink, Brian E, Fairfax, David J, Martin, Gregory S, Rossiter, Lana M, Holst, Christian L, Kim, Soong-Hoon, Leavitt, Kenneth J, Mastalerz, Harold, Han, Wen-Ching, Norris, Derek, Goyal, Bindu, Swaminathan, Shankar, Patel, Bharat, Mathur, Arvind, Vyas, Dolatrai M, Tokarski, John S, Yu, Chiang, Oppenheimer, Simone, Zhang, Hongjian, Marathe, Punit, Fargnoli, Joseph, Lee, Francis Y, Wong, Tai W, Vite, Gregory D
Published in Journal of medicinal chemistry (12.11.2009)
Published in Journal of medicinal chemistry (12.11.2009)
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Journal Article
HETEROCYCLIC INHIBITORS OF GLUTAMINASE
GUY LAIDIG, BINDU GOYAL, ERIC BRIAN SJOGREN, CHEN LI-JING, TIMOTHY FRIEND STANTON, JIM LI
Year of Publication 15.12.2016
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Year of Publication 15.12.2016
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New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases
Mastalerz, Harold, Chang, Ming, Chen, Ping, Dextraze, Pierre, Fink, Brian E., Gavai, Ashvinikumar, Goyal, Bindu, Han, Wen-Ching, Johnson, Walter, Langley, David, Lee, Francis Y., Marathe, Punit, Mathur, Arvind, Oppenheimer, Simone, Ruediger, Edward, Tarrant, James, Tokarski, John S., Vite, Gregory D., Vyas, Dolatrai M., Wong, Henry, Wong, Tai W., Zhang, Hongjian, Zhang, Guifen
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
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Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17β-hydroxysteroid dehydrogenase type 3
Fink, Brian E., Gavai, Ashvinikumar V., Tokarski, John S., Goyal, Bindu, Misra, Raj, Xiao, Hai-Yun, Kimball, S. David, Han, Wen-Ching, Norris, Derek, Spires, Thomas E., You, Dan, Gottardis, Marco M., Lorenzi, Matthew V., Vite, Gregory D.
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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Pyrimidine-based inhibitors of CaMKIIδ
Mavunkel, Babu, Xu, Yong-jin, Goyal, Bindu, Lim, Don, Lu, Qing, Chen, Zheng, Wang, Dan-Xiong, Higaki, Jeffrey, Chakraborty, Indrani, Liclican, Albert, Sideris, Steve, Laney, Maureen, Delling, Ulrike, Catalano, Rosanne, Higgins, Linda S., Wang, Hui, Wang, Jing, Feng, Ying, Dugar, Sundeep, Levy, Daniel E.
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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Discovery and Preclinical Evaluation of [4-[[1-(3-fluorophenyl)methyl]-1 H -indazol-5-ylamino]-5-methylpyrrolo[2,1- f ][1,2,4]triazin-6-yl]carbamic Acid, (3 S )-3-Morpholinylmethyl Ester (BMS-599626), a Selective and Orally Efficacious Inhibitor of Human Epidermal Growth Factor Receptor 1 and 2 Kinases
Gavai, Ashvinikumar V., Fink, Brian E., Fairfax, David J., Martin, Gregory S., Rossiter, Lana M., Holst, Christian L., Kim, Soong-Hoon, Leavitt, Kenneth J., Mastalerz, Harold, Han, Wen-Ching, Norris, Derek, Goyal, Bindu, Swaminathan, Shankar, Patel, Bharat, Mathur, Arvind, Vyas, Dolatrai M., Tokarski, John S., Yu, Chiang, Oppenheimer, Simone, Zhang, Hongjian, Marathe, Punit, Fargnoli, Joseph, Lee, Francis Y., Wong, Tai W., Vite, Gregory D.
Published in Journal of medicinal chemistry (12.11.2009)
Published in Journal of medicinal chemistry (12.11.2009)
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Synthesis and SAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1- f][1,2,4]triazine based VEGFR-2 kinase inhibitors
Borzilleri, Robert M., Cai, Zhen-wei, Ellis, Christopher, Fargnoli, Joseph, Fura, Aberra, Gerhardt, Tracy, Goyal, Bindu, Hunt, John T., Mortillo, Steven, Qian, Ligang, Tokarski, John, Vyas, Viral, Wautlet, Barri, Zheng, Xioping, Bhide, Rajeev S.
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
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4'-THIONUCLEOSIDE ANALOGUES AND THEIR PHARMACEUTICAL USE
Naduthambi, Devan, Mackman, Richard L, Clarke, Michael O, Goyal, Bindu, Squires, Neil H
Year of Publication 11.07.2024
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Year of Publication 11.07.2024
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4'-THIONUCLEOSIDE ANALOGUES AND THEIR PHARMACEUTICAL USE
GOYAL, Bindu, NADUTHAMBI, Devan, MACKMAN, Richard L, CLARKE, Michael O, SQUIRES, Neil H
Year of Publication 11.04.2024
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Year of Publication 11.04.2024
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Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17beta-hydroxysteroid dehydrogenase type 3
Fink, Brian E, Gavai, Ashvinikumar V, Tokarski, John S, Goyal, Bindu, Misra, Raj, Xiao, Hai-Yun, Kimball, S David, Han, Wen-Ching, Norris, Derek, Spires, Thomas E, You, Dan, Gottardis, Marco M, Lorenzi, Matthew V, Vite, Gregory D
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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