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2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity
Sulkowski, Parker L, Corso, Christopher D, Robinson, Nathaniel D, Scanlon, Susan E, Purshouse, Karin R, Bai, Hanwen, Liu, Yanfeng, Sundaram, Ranjini K, Hegan, Denise C, Fons, Nathan R, Breuer, Gregory A, Song, Yuanbin, Mishra-Gorur, Ketu, De Feyter, Henk M, de Graaf, Robin A, Surovtseva, Yulia V, Kachman, Maureen, Halene, Stephanie, Günel, Murat, Glazer, Peter M, Bindra, Ranjit S
Published in Science translational medicine (01.02.2017)
Published in Science translational medicine (01.02.2017)
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Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair
Sulkowski, Parker L., Sundaram, Ranjini K., Oeck, Sebastian, Corso, Christopher D., Liu, Yanfeng, Noorbakhsh, Seth, Niger, Monica, Boeke, Marta, Ueno, Daiki, Kalathil, Aravind Nambiar, Bao, Xun, Li, Jing, Shuch, Brian, Bindra, Ranjit S., Glazer, Peter M.
Published in Nature genetics (01.08.2018)
Published in Nature genetics (01.08.2018)
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Residual Convolutional Neural Network for the Determination of IDH Status in Low- and High-Grade Gliomas from MR Imaging
Chang, Ken, Bai, Harrison X., Zhou, Hao, Su, Chang, Bi, Wenya Linda, Agbodza, Ena, Kavouridis, Vasileios K., Senders, Joeky T., Boaro, Alessandro, Beers, Andrew, Zhang, Biqi, Capellini, Alexandra, Liao, Weihua, Shen, Qin, Li, Xuejun, Xiao, Bo, Cryan, Jane, Ramkissoon, Shakti, Ramkissoon, Lori, Ligon, Keith, Wen, Patrick Y., Bindra, Ranjit S., Woo, John, Arnaout, Omar, Gerstner, Elizabeth R., Zhang, Paul J., Rosen, Bruce R., Yang, Li, Huang, Raymond Y., Kalpathy-Cramer, Jayashree
Published in Clinical cancer research (01.03.2018)
Published in Clinical cancer research (01.03.2018)
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PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
Fons, Nathan R., Sundaram, Ranjini K., Breuer, Gregory A., Peng, Sen, McLean, Ryan L., Kalathil, Aravind N., Schmidt, Mark S., Carvalho, Diana M., Mackay, Alan, Jones, Chris, Carcaboso, Ángel M., Nazarian, Javad, Berens, Michael E., Brenner, Charles, Bindra, Ranjit S.
Published in Nature communications (22.08.2019)
Published in Nature communications (22.08.2019)
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Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity
Garbarino, Jennifer, Eckroate, Jillian, Sundaram, Ranjini K., Jensen, Ryan B., Bindra, Ranjit S.
Published in Translational oncology (01.09.2021)
Published in Translational oncology (01.09.2021)
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Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130
Hegan, Denise Campisi, Lu, Yuhong, Stachelek, Gregory C, Crosby, Meredith E, Bindra, Ranjit S, Glazer, Peter M
Published in Proceedings of the National Academy of Sciences - PNAS (02.02.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (02.02.2010)
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Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly
Cicconi, Alessandro, Rai, Rekha, Xiong, Xuexue, Broton, Cayla, Al-Hiyasat, Amer, Hu, Chunyi, Dong, Siying, Sun, Wenqi, Garbarino, Jennifer, Bindra, Ranjit S., Schildkraut, Carl, Chen, Yong, Chang, Sandy
Published in Nature communications (17.11.2020)
Published in Nature communications (17.11.2020)
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Regulation of DNA repair in hypoxic cancer cells
Bindra, Ranjit S., Crosby, Meredith E., Glazer, Peter M.
Published in Cancer and metastasis reviews (01.06.2007)
Published in Cancer and metastasis reviews (01.06.2007)
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The Role of Mismatch Repair in Glioblastoma Multiforme Treatment Response and Resistance
Leelatian, Nalin, Hong, Christopher S, Bindra, Ranjit S
Published in Neurosurgery clinics of North America (01.04.2021)
Published in Neurosurgery clinics of North America (01.04.2021)
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Role of Radiation Therapy in the Management of Diffuse Intrinsic Pontine Glioma: A Systematic Review
Gallitto, Matthew, Lazarev, Stanislav, Wasserman, Isaac, Stafford, James M., Wolden, Suzanne L., Terezakis, Stephanie A., Bindra, Ranjit S., Bakst, Richard L.
Published in Advances in radiation oncology (01.07.2019)
Published in Advances in radiation oncology (01.07.2019)
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Adjuvant chemotherapy and overall survival in adult medulloblastoma
Kann, Benjamin H., Lester-Coll, Nataniel H., Park, Henry S., Yeboa, Debra N., Kelly, Jacqueline R., Baehring, Joachim M., Becker, Kevin P., Yu, James B., Bindra, Ranjit S., Roberts, Kenneth B.
Published in Neuro-oncology (Charlottesville, Va.) (01.02.2017)
Published in Neuro-oncology (Charlottesville, Va.) (01.02.2017)
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CDKN2A Copy Number Loss Is an Independent Prognostic Factor in HPV-Negative Head and Neck Squamous Cell Carcinoma
Chen, William S., Bindra, Ranjit S., Mo, Allen, Hayman, Thomas, Husain, Zain, Contessa, Joseph N., Gaffney, Stephen G., Townsend, Jeffrey P., Yu, James B.
Published in Frontiers in oncology (04.04.2018)
Published in Frontiers in oncology (04.04.2018)
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Hypoxia-Induced Down-regulation of BRCA1 Expression by E2Fs
Bindra, Ranjit S., Gibson, Shannon L., Meng, Alice, Westermark, Ulrica, Jasin, Maria, Pierce, Andrew J., Bristow, Robert G., Classon, Marie K., Glazer, Peter M.
Published in Cancer research (Chicago, Ill.) (15.12.2005)
Published in Cancer research (Chicago, Ill.) (15.12.2005)
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Targeting IDH1/2 mutant cancers with combinations of ATR and PARP inhibitors
Sule, Amrita, Van Doorn, Jinny, Sundaram, Ranjini K, Ganesa, Sachita, Vasquez, Juan C, Bindra, Ranjit S
Published in NAR cancer (01.06.2021)
Published in NAR cancer (01.06.2021)
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Down-Regulation of Rad51 and Decreased Homologous Recombination in Hypoxic Cancer Cells
Bindra, Ranjit S., Schaffer, Paul J., Meng, Alice, Woo, Jennifer, Måseide, Kårstein, Roth, Matt E., Lizardi, Paul, Hedley, David W., Bristow, Robert G., Glazer, Peter M.
Published in Molecular and Cellular Biology (01.10.2004)
Published in Molecular and Cellular Biology (01.10.2004)
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Delayed Cerebral Vasculopathy Following Cranial Radiation Therapy for Pediatric Tumors
Wang, Chenyang, Roberts, Kenneth B., Bindra, Ranjit S., Chiang, Veronica L., Yu, James B.
Published in Pediatric neurology (01.06.2014)
Published in Pediatric neurology (01.06.2014)
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