Deep sequencing of 10,000 human genomes
Telenti, Amalio, Pierce, Levi C. T., Biggs, William H., di Iulio, Julia, Wong, Emily H. M., Fabani, Martin M., Kirkness, Ewen F., Moustafa, Ahmed, Shah, Naisha, Xie, Chao, Brewerton, Suzanne C., Bulsara, Nadeem, Garner, Chad, Metzker, Gary, Sandoval, Efren, Perkins, Brad A., Och, Franz J., Turpaz, Yaron, Venter, J. Craig
Published in Proceedings of the National Academy of Sciences - PNAS (18.10.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (18.10.2016)
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Journal Article
Profiling of Short-Tandem-Repeat Disease Alleles in 12,632 Human Whole Genomes
Tang, Haibao, Kirkness, Ewen F., Lippert, Christoph, Biggs, William H., Fabani, Martin, Guzman, Ernesto, Ramakrishnan, Smriti, Lavrenko, Victor, Kakaradov, Boyko, Hou, Claire, Hicks, Barry, Heckerman, David, Och, Franz J., Caskey, C. Thomas, Venter, J. Craig, Telenti, Amalio
Published in American journal of human genetics (02.11.2017)
Published in American journal of human genetics (02.11.2017)
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Journal Article
Inhibition of Drug-Resistant Mutants of ABL, KIT, and EGF Receptor Kinases
Carter, Todd A., Wodicka, Lisa M., Shah, Neil P., Velasco, Anne Marie, Fabian, Miles A., Treiber, Daniel K., Milanov, Zdravko V., Atteridge, Corey E., Biggs, William H., Edeen, Philip T., Floyd, Mark, Ford, Julia M., Grotzfeld, Robert M., Herrgard, Sanna, Insko, Darren E., Mehta, Shamal A., Patel, Hitesh K., Pao, William, Sawyers, Charles L., Varmus, Harold, Zarrinkar, Patrick P., Lockhart, David J.
Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (02.08.2005)
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Journal Article
Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults
Perkins, Bradley A., Caskey, C. Thomas, Brar, Pamila, Dec, Eric, Karow, David S., Kahn, Andrew M., Hou, Ying-Chen Claire, Shah, Naisha, Boeldt, Debbie, Coughlin, Erin, Hands, Gabby, Lavrenko, Victor, Yu, James, Procko, Andrea, Appis, Julia, Dale, Anders M., Guo, Lining, Jönsson, Thomas J., Wittmann, Bryan M., Bartha, Istvan, Ramakrishnan, Smriti, Bernal, Axel, Brewer, James B., Brewerton, Suzanne, Biggs, William H., Turpaz, Yaron, Venter, J. Craig
Published in Proceedings of the National Academy of Sciences - PNAS (03.04.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (03.04.2018)
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Journal Article
A small molecule-kinase interaction map for clinical kinase inhibitors
Zarrinkar, Patrick P, Floyd, Mark, Lai, Andiliy G, Atteridge, Corey E, Carter, Todd A, Galvin, Margaret, Mehta, Shamal A, Lélias, Jean-Michel, Wodicka, Lisa M, Benedetti, Michael G, Azimioara, Mihai D, Treiber, Daniel K, Insko, Darren E, Insko, Michael A, Edeen, Philip T, Gerlach, Jay L, Fabian, Miles A, Grotzfeld, Robert M, Lockhart, David J, Patel, Hitesh K, Milanov, Zdravko V, Ciceri, Pietro, Biggs, William H, Herrgard, Sanna, Velasco, Anne Marie, Ford, Julia M
Published in Nature biotechnology (01.03.2005)
Published in Nature biotechnology (01.03.2005)
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Journal Article
Disruption of Forkhead Transcription Factor (FOXO) Family Members in Mice Reveals Their Functional Diversification
Hosaka, Taisuke, Biggs, William H., Tieu, David, Boyer, Antonia D., Varki, Nissi M., Cavenee, Webster K., Arden, Karen C., White, Raymond L.
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2004)
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Journal Article
Structure of the kinase domain of an imatinib-resistant abl mutant in complex with the aurora kinase inhibitor VX-680
YOUNG, Matthew A, SHAH, Neil P, SAWYERS, Charles L, KURIYAN, John, CHAO, Luke H, SEELIGER, Markus, MILANOV, Zdravko V, BIGGS, William H, TREIBER, Daniel K, PATEL, Hitesh K, ZARRINKAR, Patrick P, LOCKHART, David J
Published in Cancer research (Chicago, Ill.) (15.01.2006)
Published in Cancer research (Chicago, Ill.) (15.01.2006)
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Journal Article
Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
Accili, Domenico, Nakae, Jun, Biggs, William H, Kitamura, Tadahiro, Cavenee, Webster K, Wright, Christopher V.E, Arden, Karen C
Published in Nature genetics (01.10.2002)
Published in Nature genetics (01.10.2002)
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Journal Article
Protein Kinase B/Akt-Mediated Phosphorylation Promotes Nuclear Exclusion of the Winged Helix Transcription Factor FKHR1
Biggs, William H., Meisenhelder, Jill, Hunter, Tony, Cavenee, Webster K., Arden, Karen C.
Published in Proceedings of the National Academy of Sciences - PNAS (22.06.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (22.06.1999)
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Journal Article
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
Kitamura, Tadahiro, Nakae, Jun, Kitamura, Yukari, Kido, Yoshiaki, Biggs, 3rd, William H, Wright, Christopher V E, White, Morris F, Arden, Karen C, Accili, Domenico
Published in The Journal of clinical investigation (01.12.2002)
Published in The Journal of clinical investigation (01.12.2002)
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Journal Article
Tuning a Three-Component Reaction For Trapping Kinase Substrate Complexes
Statsuk, Alexander V, Maly, Dustin J, Seeliger, Markus A, Fabian, Miles A, Biggs, William H, Lockhart, David J, Zarrinkar, Patrick P, Kuriyan, John, Shokat, Kevan M
Published in Journal of the American Chemical Society (24.12.2008)
Published in Journal of the American Chemical Society (24.12.2008)
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Journal Article
Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites
Long, Tao, Hicks, Michael, Yu, Hung-Chun, Biggs, William H, Kirkness, Ewen F, Menni, Cristina, Zierer, Jonas, Small, Kerrin S, Mangino, Massimo, Messier, Helen, Brewerton, Suzanne, Turpaz, Yaron, Perkins, Brad A, Evans, Anne M, Miller, Luke A D, Guo, Lining, Caskey, C Thomas, Schork, Nicholas J, Garner, Chad, Spector, Tim D, Venter, J Craig, Telenti, Amalio
Published in Nature genetics (01.04.2017)
Published in Nature genetics (01.04.2017)
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Journal Article
Fast and accurate HLA typing from short-read next-generation sequence data with xHLA
Xie, Chao, Yeo, Zhen Xuan, Wong, Marie, Piper, Jason, Long, Tao, Kirkness, Ewen F., Biggs, William H., Bloom, Ken, Spellman, Stephen, Vierra-Green, Cynthia, Brady, Colleen, Scheuermann, Richard H., Telenti, Amalio, Howard, Sally, Brewerton, Suzanne, Turpaz, Yaron, Venter, J. Craig
Published in Proceedings of the National Academy of Sciences - PNAS (25.07.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (25.07.2017)
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Journal Article
The human noncoding genome defined by genetic diversity
di Iulio, Julia, Bartha, Istvan, Wong, Emily H. M., Yu, Hung-Chun, Lavrenko, Victor, Yang, Dongchan, Jung, Inkyung, Hicks, Michael A., Shah, Naisha, Kirkness, Ewen F., Fabani, Martin M., Biggs, William H., Ren, Bing, Venter, J. Craig, Telenti, Amalio
Published in Nature genetics (01.03.2018)
Published in Nature genetics (01.03.2018)
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Journal Article
Analytical performance validation of a coronary heart disease risk assessment multi-analyte proteomic test
Nolan, Niamh, Tee, Lilian, Vijayakumar, Swathi, Burazor, Ivana, Hytopoulos, Evangelos, Biggs, 3rd, William H, Beggs, Michael, French, Cynthia, Harrington, Douglas S
Published in Expert opinion on medical diagnostics (01.03.2013)
Published in Expert opinion on medical diagnostics (01.03.2013)
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Journal Article
Analysis of the Regulation of the A33 Antigen Gene Reveals Intestine-specific Mechanisms of Gene Expression
Johnstone, Cameron N., White, Sara J., Tebbutt, Niall C., Clay, Fiona J., Ernst, Matthias, Biggs, William H., Viars, Carrie S., Czekay, Suzanne, Arden, Karen C., Heath, Joan K.
Published in The Journal of biological chemistry (13.09.2002)
Published in The Journal of biological chemistry (13.09.2002)
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Journal Article