Acquired On-Target Clinical Resistance Validates FGFR4 as a Driver of Hepatocellular Carcinoma
Hatlen, Megan A, Schmidt-Kittler, Oleg, Sherwin, Cori Ann, Rozsahegyi, Emily, Rubin, Nooreen, Sheets, Michael P, Kim, Joseph L, Miduturu, Chandrasekhar, Bifulco, Neil, Brooijmans, Natasja, Shi, Hongliang, Guzi, Timothy, Boral, Andy, Lengauer, Christoph, Dorsch, Marion, Kim, Richard D, Kang, Yoon-Koo, Wolf, Beni B, Hoeflich, Klaus P
Published in Cancer discovery (01.12.2019)
Published in Cancer discovery (01.12.2019)
Get full text
Journal Article
Evaluation of Protein Kinase cAMP-Activated Catalytic Subunit Alpha as a Therapeutic Target for Fibrolamellar Carcinoma
Schalm, Stefanie S., O’Hearn, Erin, Wilson, Kevin, LaBranche, Timothy P., Silva, Grace, Zhang, Zhuo, DiPietro, Lucian, Bifulco, Neil, Woessner, Richard, Stransky, Nicolas, Sappal, Darshan, Campbell, Robert, Lobbardi, Riadh, Palmer, Michael, Kim, Joseph, Ye, Chaoyang, Dorsch, Marion, Lengauer, Christoph, Guzi, Timothy, Kadambi, Vivek, Garner, Andrew, Hoeflich, Klaus P.
Published in Gastro hep advances (2023)
Published in Gastro hep advances (2023)
Get full text
Journal Article
First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway
Hagel, Margit, Miduturu, Chandra, Sheets, Michael, Rubin, Nooreen, Weng, Weifan, Stransky, Nicolas, Bifulco, Neil, Kim, Joseph L, Hodous, Brian, Brooijmans, Natasja, Shutes, Adam, Winter, Christopher, Lengauer, Christoph, Kohl, Nancy E, Guzi, Timothy
Published in Cancer discovery (01.04.2015)
Published in Cancer discovery (01.04.2015)
Get full text
Journal Article
ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii
Durand-Réville, Thomas F., Guler, Satenig, Comita-Prevoir, Janelle, Chen, Brendan, Bifulco, Neil, Huynh, Hoan, Lahiri, Sushmita, Shapiro, Adam B., McLeod, Sarah M., Carter, Nicole M., Moussa, Samir H., Velez-Vega, Camilo, Olivier, Nelson B., McLaughlin, Robert, Gao, Ning, Thresher, Jason, Palmer, Tiffany, Andrews, Beth, Giacobbe, Robert A., Newman, Joseph V., Ehmann, David E., de Jonge, Boudewijn, O'Donnell, John, Mueller, John P., Tommasi, Rubén A., Miller, Alita A.
Published in Nature microbiology (30.06.2017)
Published in Nature microbiology (30.06.2017)
Get full text
Journal Article
Abstract 1279: Development of a selective CDK2-E inhibitor in CCNE driven cancers
Choi, Yoon J., Wenglowsky, Steve, Brown, Victoria, Bifulco, Neil, Choi, Yeon S., Guo, Jian, Hatlen, Megan, Kim, Joseph, LaBranche, Tim, Lobbardi, Riadh, Perola, Emanuele, Rozsahegyi, Emily, Maynard, Michelle, Ramsden, Phil, Silva, Grace, Stevison, Faith, Vargas, Richard, Wang, Ruduan, Wilson, Doug, Woessner, Rich, Zhang, Dean, Meissner, Rob, Hoeflich, Klaus, Dorsch, Marion
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Get full text
Journal Article
Abstract P6-10-07: CDK2 inhibition with BLU-222 in combination with ribociclib demonstrates robust antitumor activity in pre-clinical models of CDK4/6 inhibitor-naïve and -resistant HR+/HER2- breast cancer
Brown, Victoria, House, Nealia, Ramsden, Phil, Ho, Karen, Wu, Hsin-Jung, Wilker, Erik, Guo, Jian, Chen, Maxine, Wilson, Douglas, Bifulco, Neil, Wenglowsky, Steve, Choi, Yoon Jong, Faia, Kerrie
Published in Cancer research (Chicago, Ill.) (01.03.2023)
Published in Cancer research (Chicago, Ill.) (01.03.2023)
Get full text
Journal Article
Abstract B127: Evaluating PRKACA as a therapeutic target for Fibrolamellar Carcinoma
Schalm, Stefanie S, O’Hearn, Erin, Wilson, Kevin, LaBranche, Timothy, Silva, Grace, DiPietro, Lucian, Bifulco, Neil, Woessner, Richard, Stransky, Nicolas, Sappal, Darshan, Shutes, Adam, Campbell, Robert, Lobbardi, Riadh, Palmer, Michael, Kim, Joseph, Miller, Stephen, Dorsch, Marion, Lengauer, Christoph, Guzi, Timothy, Kadambi, Vivek, Garner, Andrew, Hoeflich, Klaus P
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
Get full text
Journal Article
Abstract A118: Identification of resistance mechanisms to FGFR4 targeted therapy in hepatocellular carcinoma
Hatlen, Megan A, Schmidt-Kittler, Oleg, Sherwin, Cori-Ann, Rozsahegyi, Emily, Rubin, Nooreen, Sheets, Michael, Kim, Joseph L, Miduturu, Chandra, Bifulco, Neil, Brooijmans, Natasja, Shi, Hongliang, Guzi, Timothy, Boral, Andy, Lengauer, Christoph, Dorsch, Marion, Kim, Richard D, Kang, Yoon-Koo, Wolf, Beni B, Hoeflich, Klaus P
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
Get full text
Journal Article
Abstract 2306: BLU-222, an investigational, potent, and selective CDK2 inhibitor, demonstrated robust antitumor activity in CCNE1 -amplified ovarian cancer models
Brown, Victoria, Ramsden, Phil, House, Nealia, Vargas, Richard, Guo, Jian, Wang, Ruduan, Lobbardi, Riadh, Chen, Maxine, Wilson, Douglas, Kim, Joseph, Bifulco, Neil, Maynard, Michelle, Perola, Emanuele, Zhang, Dean, Wenglowsky, Steve, Choi, Yoon Jong
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Get full text
Journal Article
Abstract LB-324: First isoform selective inhibitor of FGFR4 for the treatment of genomically defined patients with hepatocellular carcinoma
Hagel, Margit, Miduturu, Chandra, Sheets, Mike, Weng, Weifan, Rubin, Nooreen, Bifulco, Neil, DiPietro, Lucian, Kim, Joseph, Brooijmans, Natasja, Stransky, Nicolas, Winter, Christopher, Lengauer, Christoph, Guzi, Timothy
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Get full text
Journal Article
NTRK에 관련된 장애 치료용으로 유용한 화합물 및 조성물
BIFULCO NEIL, WENGLOWSKY STEVEN MARK, MIDUTURU CHANDRASEKHAR V, BROOIJMANS NATASJA
Year of Publication 30.04.2018
Get full text
Year of Publication 30.04.2018
Patent
INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR
BIFULCO NEIL JR, HODOUS BRIAN L, KIM JOSEPH L, WENGLOWSKY STEVEN MARK, MIDUTURU CHANDRASEKHAR V, BROOIJMANS NATASJA
Year of Publication 13.10.2020
Get full text
Year of Publication 13.10.2020
Patent
NTRK 관련 장애의 치료에 유용한 화합물 및 조성물
BIFULCO NEIL JR, WENGLOWSKY STEVEN MARK, KIM JOSEPH L, MIDUTURU CHANDRASEKHAR V
Year of Publication 17.07.2018
Get full text
Year of Publication 17.07.2018
Patent
INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR
BIFULCO NEIL JR, HODOUS BRIAN L, DIPIETRO LUCIAN V, MIDUTURU CHANDRASEKHAR V
Year of Publication 17.06.2016
Get full text
Year of Publication 17.06.2016
Patent
ETX2514 is a broad-spectrum [beta]-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii
Durand-réville, Thomas F, Guler, Satenig, Comita-prevoir, Janelle, Chen, Brendan, Bifulco, Neil, Huynh, Hoan, Lahiri, Sushmita, Shapiro, Adam B, Mcleod, Sarah M, Carter, Nicole M, Moussa, Samir H, Velez-vega, Camilo, Olivier, Nelson B, Mclaughlin, Robert, Gao, Ning, Thresher, Jason, Palmer, Tiffany, Andrews, Beth, Giacobbe, Robert A, Newman, Joseph V, Ehmann, David E, De Jonge, Boudewijn, O'donnell, John, Mueller, John P, Tommasi, Rubén A, Miller, Alita A
Published in Nature microbiology (01.09.2017)
Published in Nature microbiology (01.09.2017)
Get full text
Journal Article
INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR
BIFULCO NEIL JR, HODOUS BRIAN L, KIM JOSEPH L, WENGLOWSKY STEVEN MARK, MIDUTURU CHANDRASEKHAR V, BROOIJMANS NATASJA
Year of Publication 17.03.2015
Get full text
Year of Publication 17.03.2015
Patent
HETEROBICYCLIC COMPOUNDS AS BETA-LACTAMASE INHIBITORS
COMITA PREVOIR JANELLE, GULER SATENIG, WU YE, HUYNH HOAN, CHEN BRENDAN, BIFULCO NEIL, ZHAO LIANG, DURAND REVILLE THOMAS, XIONG HUI, GENG BOLIN, DUSSAULT DAEMIAN, MCGUIRE HELEN, BIST SHANTA
Year of Publication 09.12.2014
Get full text
Year of Publication 09.12.2014
Patent
INHIBITORS OF PROTEIN KINASE A
Palmer, Michael Ross, Kim, Joseph L, Bifulco, Neil, Wilson, Kevin J, Schalm, Stefanie Sandra
Year of Publication 25.04.2024
Get full text
Year of Publication 25.04.2024
Patent
INHIBITORS OF PROTEIN KINASE A
WILSON, Kevin, KIM, Joseph, PALMER, Michael, BIFULCO, Neil, SCHALM, Stefanie
Year of Publication 04.08.2022
Get full text
Year of Publication 04.08.2022
Patent