Tau stabilizes microtubules by binding at the interface between tubulin heterodimers
Kadavath, Harindranath, Romina V. Hofele, Jacek Biernat, Satish Kumar, Katharina Tepper, Henning Urlaub, Eckhard Mandelkow, Markus Zweckstetter
Published in Proceedings of the National Academy of Sciences - PNAS (16.06.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (16.06.2015)
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Journal Article
Lysine/RNA-interactions drive and regulate biomolecular condensation
Ukmar-Godec, Tina, Hutten, Saskia, Grieshop, Matthew P., Rezaei-Ghaleh, Nasrollah, Cima-Omori, Maria-Sol, Biernat, Jacek, Mandelkow, Eckhard, Söding, Johannes, Dormann, Dorothee, Zweckstetter, Markus
Published in Nature communications (02.07.2019)
Published in Nature communications (02.07.2019)
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Journal Article
Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau
Cabrales Fontela, Yunior, Kadavath, Harindranath, Biernat, Jacek, Riedel, Dietmar, Mandelkow, Eckhard, Zweckstetter, Markus
Published in Nature communications (07.12.2017)
Published in Nature communications (07.12.2017)
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Journal Article
Folding of the Tau Protein on Microtubules
Kadavath, Harindranath, Jaremko, Mariusz, Jaremko, Łukasz, Biernat, Jacek, Mandelkow, Eckhard, Zweckstetter, Markus
Published in Angewandte Chemie International Edition (24.08.2015)
Published in Angewandte Chemie International Edition (24.08.2015)
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Journal Article
Structural Impact of Tau Phosphorylation at Threonine 231
Schwalbe, Martin, Kadavath, Harindranath, Biernat, Jacek, Ozenne, Valery, Blackledge, Martin, Mandelkow, Eckhard, Zweckstetter, Markus
Published in Structure (London) (04.08.2015)
Published in Structure (London) (04.08.2015)
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Journal Article
FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease
Mair, Waltraud, Muntel, Jan, Tepper, Katharina, Tang, Shaojun, Biernat, Jacek, Seeley, William W, Kosik, Kenneth S, Mandelkow, Eckhard, Steen, Hanno, Steen, Judith A
Published in Analytical chemistry (Washington) (05.04.2016)
Published in Analytical chemistry (Washington) (05.04.2016)
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Journal Article
Oligomer Formation of Tau Protein Hyperphosphorylated in Cells
Tepper, Katharina, Biernat, Jacek, Kumar, Satish, Wegmann, Susanne, Timm, Thomas, Hübschmann, Sabrina, Redecke, Lars, Mandelkow, Eva-Maria, Müller, Daniel J., Mandelkow, Eckhard
Published in The Journal of biological chemistry (05.12.2014)
Published in The Journal of biological chemistry (05.12.2014)
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Journal Article
Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity
FATOUROS, Chronis, JEELANI PIR, Ghulam, BIERNAT, Jacek, KOUSHIKA, Sandhya Padmanabhan, MANDELKOW, Eckhard, MANDELKOW, Eva-Maria, SCHMIDT, Enrico, BAUMEISTER, Ralf
Published in Human molecular genetics (15.08.2012)
Published in Human molecular genetics (15.08.2012)
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Journal Article
Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex
Oroz, Javier, Chang, Bliss J., Wysoczanski, Piotr, Lee, Chung-Tien, Pérez-Lara, Ángel, Chakraborty, Pijush, Hofele, Romina V., Baker, Jeremy D., Blair, Laura J., Biernat, Jacek, Urlaub, Henning, Mandelkow, Eckhard, Dickey, Chad A., Zweckstetter, Markus
Published in Nature communications (31.10.2018)
Published in Nature communications (31.10.2018)
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Journal Article
Structural Impact of Proline-Directed Pseudophosphorylation at AT8, AT100, and PHF1 Epitopes on 441-Residue Tau
Bibow, Stefan, Ozenne, Valéry, Biernat, Jacek, Blackledge, Martin, Mandelkow, Eckhard, Zweckstetter, Markus
Published in Journal of the American Chemical Society (12.10.2011)
Published in Journal of the American Chemical Society (12.10.2011)
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Journal Article
Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation
Jeganathan, Sadasivam, Hascher, Antje, Chinnathambi, Subashchandrabose, Biernat, Jacek, Mandelkow, Eva-Maria, Mandelkow, Eckhard
Published in The Journal of biological chemistry (14.11.2008)
Published in The Journal of biological chemistry (14.11.2008)
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Journal Article
FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments
Kaniyappan, Senthilvelrajan, Tepper, Katharina, Biernat, Jacek, Chandupatla, Ram Reddy, Hübschmann, Sabrina, Irsen, Stephan, Bicher, Sandra, Klatt, Christoph, Mandelkow, Eva-Maria, Mandelkow, Eckhard
Published in Molecular neurodegeneration (16.07.2020)
Published in Molecular neurodegeneration (16.07.2020)
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Journal Article
Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity
Kumar, Satish, Tepper, Katharina, Kaniyappan, Senthilvelrajan, Biernat, Jacek, Wegmann, Susanne, Mandelkow, Eva-Maria, Müller, Daniel J., Mandelkow, Eckhard
Published in The Journal of biological chemistry (18.07.2014)
Published in The Journal of biological chemistry (18.07.2014)
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Journal Article
Conformational Changes Specific for Pseudophosphorylation at Serine 262 Selectively Impair Binding of Tau to Microtubules
Fischer, Daniela, Mukrasch, Marco D, Biernat, Jacek, Bibow, Stefan, Blackledge, Martin, Griesinger, Christian, Mandelkow, Eckhard, Zweckstetter, Markus
Published in Biochemistry (Easton) (27.10.2009)
Published in Biochemistry (Easton) (27.10.2009)
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