Heparan sulfate proteoglycans in beta cells provide a critical link between endoplasmic reticulum stress, oxidative stress and type 2 diabetes
Dhounchak, Sarita, Popp, Sarah K, Brown, Debra J, Laybutt, D. Ross, Biden, Trevor J, Bornstein, Stefan R, Parish, Christopher R, Simeonovic, Charmaine J
Published in PloS one (04.06.2021)
Published in PloS one (04.06.2021)
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Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass
Cantley, James, Davenport, Aimee, Vetterli, Laurène, Nemes, Nandor J., Whitworth, P. Tess, Boslem, Ebru, Thai, Le May, Mellett, Natalie, Meikle, Peter J., Hoehn, Kyle L., James, David E., Biden, Trevor J.
Published in Diabetologia (01.01.2019)
Published in Diabetologia (01.01.2019)
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Regulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84
Montgomery, Magdalene K, Osborne, Brenna, Brandon, Amanda E, O'Reilly, Liam, Fiveash, Corrine E, Brown, Simon H J, Wilkins, Brendan P, Samsudeen, Azrah, Yu, Josephine, Devanapalli, Beena, Hertzog, Ashley, Tolun, Adviye A, Kavanagh, Tomas, Cooper, Antony A, Mitchell, Todd W, Biden, Trevor J, Smith, Nicola J, Cooney, Gregory J, Turner, Nigel
Published in The FASEB journal (01.11.2019)
Published in The FASEB journal (01.11.2019)
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A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking
Boslem, Ebru, MacIntosh, Gemma, Preston, Amanda M, Bartley, Clarissa, Busch, Anna K, Fuller, Maria, Laybutt, D Ross, Meikle, Peter J, Biden, Trevor J
Published in Biochemical journal (01.04.2011)
Published in Biochemical journal (01.04.2011)
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Short-term inhibition of autophagy benefits pancreatic β-cells by augmenting ether lipids and peroxisomal function, and by countering depletion of n-3 polyunsaturated fatty acids after fat-feeding
Chu, Kwan Yi, Mellet, Natalie, Thai, Le May, Meikle, Peter J., Biden, Trevor J.
Published in Molecular metabolism (Germany) (01.10.2020)
Published in Molecular metabolism (Germany) (01.10.2020)
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Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling
AKERFELDT, Mia C, HOWES, Jennifer, JENG YIE CHAN, STEVENS, Veronica A, BOUBENNA, Nacer, MCGUIRE, Helen M, KING, Cecile, BIDEN, Trevor J, ROSS LAYBUTT, D
Published in Diabetes (New York, N.Y.) (01.11.2008)
Published in Diabetes (New York, N.Y.) (01.11.2008)
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Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by co-ordinating insulin biosynthesis with secretory granule formation
Sue, Nancy, Thai, Le May, Saito, Atsushi, Boyer, Cierra K, Fordham, Ashleigh M, Yan, Chenxu, Davenport, Aimee, Tao, Jiang, Bensellam, Mohammed, Cantley, James, Shi, Yan-Chuan, Stephens, Samuel B, Imaizumi, Kazunori, Biden, Trevor J
Published in Molecular metabolism (Germany) (01.01.2024)
Published in Molecular metabolism (Germany) (01.01.2024)
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A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens
Pearson, Gemma L, Mellett, Natalie, Chu, Kwan Yi, Boslem, Ebru, Meikle, Peter J, Biden, Trevor J
Published in Molecular metabolism (Germany) (01.06.2016)
Published in Molecular metabolism (Germany) (01.06.2016)
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Glucose homeostasis in mice is transglutaminase 2 independent
Iismaa, Siiri E, Aplin, Mark, Holman, Sara, Yiu, Ting W, Jackson, Kristy, Burchfield, James G, Mitchell, Christopher J, O'Reilly, Liam, Davenport, Aimee, Cantley, James, Schmitz-Peiffer, Carsten, Biden, Trevor J, Cooney, Gregory J, Graham, Robert M
Published in PloS one (22.05.2013)
Published in PloS one (22.05.2013)
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Chronic Hyperglycemia, Independent of Plasma Lipid Levels, Is Sufficient for the Loss of β-Cell Differentiation and Secretory Function in the db/db Mouse Model of Diabetes
KJØRHOLT, Cecilie, AKERFELDT, Mia C, BIDEN, Trevor J, LAYBUTT, D. Ross
Published in Diabetes (New York, N.Y.) (01.09.2005)
Published in Diabetes (New York, N.Y.) (01.09.2005)
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Journal Article
Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus
Biden, Trevor J, Boslem, Ebru, Chu, Kwan Yi, Sue, Nancy
Published in Trends in endocrinology and metabolism (01.08.2014)
Published in Trends in endocrinology and metabolism (01.08.2014)
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Increased Fatty Acid Desaturation and Enhanced Expression of Stearoyl Coenzyme A Desaturase Protects Pancreatic β-Cells from Lipoapoptosis
BUSCH, Anna K, GURISIK, Ebru, CORDERY, Damien V, SUDLOW, Michelle, DENYER, Gareth S, LAYBUTT, D. Ross, HUGHES, William E, BIDEN, Trevor J
Published in Diabetes (New York, N.Y.) (01.10.2005)
Published in Diabetes (New York, N.Y.) (01.10.2005)
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Deletion of PKCε Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse β-Cells
Cantley, James, Burchfield, James G., Pearson, Gemma L., Schmitz-Peiffer, Carsten, Leitges, Michael, Biden, Trevor J.
Published in Diabetes (New York, N.Y.) (01.08.2009)
Published in Diabetes (New York, N.Y.) (01.08.2009)
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β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling
Thai, Le May, O’Reilly, Liam, Reibe-Pal, Saskia, Sue, Nancy, Holliday, Holly, Small, Lewin, Schmitz-Peiffer, Carsten, Dhenni, Rama, Wang-Wei Tsai, Vicky, Norris, Nicholas, Yau, Belinda, Zhang, Xuan, Lee, Kailun, Yan, Chenxu, Shi, Yan-Chuan, Kebede, Melkam A., Brink, Robert, Cooney, Gregory J., Irvine, Katharine M., Breit, Samuel N., Phan, Tri G., Swarbrick, Alexander, Biden, Trevor J.
Published in iScience (21.04.2023)
Published in iScience (21.04.2023)
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Expression Profiling of Palmitate- and Oleate-Regulated Genes Provides Novel Insights Into the Effects of Chronic Lipid Exposure on Pancreatic β-Cell Function
BUSCH, Anna K, CORDERY, Damien, DENYER, Gareth S, BIDEN, Trevor J
Published in Diabetes (New York, N.Y.) (01.04.2002)
Published in Diabetes (New York, N.Y.) (01.04.2002)
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A Role for Protein Phosphatase 2A–Like Activity, but Not Atypical Protein Kinase Cζ, in the Inhibition of Protein Kinase B/Akt and Glycogen Synthesis by Palmitate
CAZZOLLI, Rosanna, CARPENTER, Lee, BIDEN, Trevor J, SCHMITZ-PEIFFER, Carsten
Published in Diabetes (New York, N.Y.) (01.10.2001)
Published in Diabetes (New York, N.Y.) (01.10.2001)
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