Prophylaxis with human serum butyrylcholinesterase protects Göttingen minipigs exposed to a lethal high-dose of sarin vapor
Saxena, Ashima, Hastings, Nicholas B., Sun, Wei, Dabisch, Paul A., Hulet, Stanley W., Jakubowski, Edward M., Mioduszewski, Robert J., Doctor, Bhupendra P.
Published in Chemico-biological interactions (05.08.2015)
Published in Chemico-biological interactions (05.08.2015)
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Journal Article
[+]-Huperzine A Protects Against Soman Toxicity in Guinea Pigs
Wang, Ying, Wei, Yanling, Oguntayo, Samuel, Jensen, Neil, Doctor, Bhupendra P., Nambiar, Madhusoodana P.
Published in Neurochemical research (01.12.2011)
Published in Neurochemical research (01.12.2011)
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A combination of [+] and [−]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs
Wang, Ying, Wei, Yanling, Oguntayo, Samuel, Doctor, Bhupendra P., Nambiar, Madhusoodana P.
Published in Chemico-biological interactions (25.03.2013)
Published in Chemico-biological interactions (25.03.2013)
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Journal Article
Protective efficacy of catalytic bioscavenger, paraoxonase 1 against sarin and soman exposure in guinea pigs
Valiyaveettil, Manojkumar, Alamneh, Yonas, Rezk, Peter, Biggemann, Lionel, Perkins, Michael W., Sciuto, Alfred M., Doctor, Bhupendra P., Nambiar, Madhusoodana P.
Published in Biochemical pharmacology (15.03.2011)
Published in Biochemical pharmacology (15.03.2011)
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Developing procedures for the large-scale purification of human serum butyrylcholinesterase
Saxena, Ashima, Luo, Chunyuan, Doctor, Bhupendra P.
Published in Protein expression and purification (01.10.2008)
Published in Protein expression and purification (01.10.2008)
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Journal Article
Pretreatment with human serum butyrylcholinesterase alone prevents cardiac abnormalities, seizures, and death in Göttingen minipigs exposed to sarin vapor
Saxena, Ashima, Sun, Wei, Dabisch, Paul A., Hulet, Stanley W., Hastings, Nicholas B., Jakubowski, Edward M., Mioduszewski, Robert J., Doctor, Bhupendra P.
Published in Biochemical pharmacology (15.12.2011)
Published in Biochemical pharmacology (15.12.2011)
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Journal Article
Demonstration of in vivo stability and lack of immunogenicity of a polyethyleneglycol-conjugated recombinant CHO-derived butyrylcholinesterase bioscavenger using a homologous macaque model
Rosenberg, Yvonne J., Saxena, Ashima, Sun, Wei, Jiang, Xiaoming, Chilukuri, Nageswararao, Luo, Chunjuan, Doctor, Bhupendra P., Lee, Keunmyoung D.
Published in Chemico-biological interactions (06.09.2010)
Published in Chemico-biological interactions (06.09.2010)
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Efficient hydrolysis of the chemical warfare nerve agent tabun by recombinant and purified human and rabbit serum paraoxonase 1
Valiyaveettil, Manojkumar, Alamneh, Yonas, Biggemann, Lionel, Soojhawon, Iswarduth, Doctor, Bhupendra P., Nambiar, Madhusoodana P.
Published in Biochemical and biophysical research communications (03.12.2010)
Published in Biochemical and biophysical research communications (03.12.2010)
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[+]-Huperzine A treatment protects against N-methyl- d-aspartate-induced seizure/ status epilepticus in rats
Coleman, Brian R., Ratcliffe, Ruthie H., Oguntayo, Samuel A., Shi, Xuerong, Doctor, Bhupendra P., Gordon, Richard K., Nambiar, Madhusoodana P.
Published in Chemico-biological interactions (25.09.2008)
Published in Chemico-biological interactions (25.09.2008)
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Journal Article
Recombinant paraoxonase 1 protects against sarin and soman toxicity following microinstillation inhalation exposure in guinea pigs
Valiyaveettil, Manojkumar, Alamneh, Yonas, Rezk, Peter, Perkins, Michael W., Sciuto, Alfred M., Doctor, Bhupendra P., Nambiar, Madhusoodana P.
Published in Toxicology letters (10.05.2011)
Published in Toxicology letters (10.05.2011)
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Advantages of the WRAIR whole blood cholinesterase assay: Comparative analysis to the micro-Ellman, Test-mate ChE™, and Michel (ΔpH) assays
Haigh, Julian R., Lefkowitz, Lee J., Capacio, Benedict R., Doctor, Bhupendra P., Gordon, Richard K.
Published in Chemico-biological interactions (25.09.2008)
Published in Chemico-biological interactions (25.09.2008)
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Journal Article
Structural analogs of huperzine A improve survival in guinea pigs exposed to soman
Gunosewoyo, Hendra, Tipparaju, Suresh K., Pieroni, Marco, Wang, Ying, Doctor, Bhupendra P., Nambiar, Madhusoodana P., Kozikowski, Alan P.
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
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Hydrolysis potential of recombinant human skin and kidney prolidase against diisopropylfluorophosphate and sarin by in vitro analysis
Costante, Michael, Biggemann, Lionel, Alamneh, Yonas, Soojhawon, Iswarduth, Short, Radley, Nigam, Savita, Garcia, Gregory, Doctor, Bhupendra P., Valiyaveettil, Manojkumar, Nambiar, Madhusoodana P.
Published in Toxicology in vitro (01.02.2012)
Published in Toxicology in vitro (01.02.2012)
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Pharmacokinetics and immunologic consequences of repeated administrations of purified heterologous and homologous butyrylcholinesterase in mice
Sun, Wei, Luo, Chunyuan, Naik, Ramachandra S., Doctor, Bhupendra P., Saxena, Ashima
Published in Life sciences (1973) (21.10.2009)
Published in Life sciences (1973) (21.10.2009)
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