A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface
de Jong, Rob N, Beurskens, Frank J, Verploegen, Sandra, Strumane, Kristin, van Kampen, Muriel D, Voorhorst, Marleen, Horstman, Wendy, Engelberts, Patrick J, Oostindie, Simone C, Wang, Guanbo, Heck, Albert J R, Schuurman, Janine, Parren, Paul W H I
Published in PLoS biology (01.01.2016)
Published in PLoS biology (01.01.2016)
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Using a Delphi technique to seek consensus regarding definitions, descriptions and classification of terms related to implicit and explicit forms of motor learning
Kleynen, Melanie, Braun, Susy M, Bleijlevens, Michel H, Lexis, Monique A, Rasquin, Sascha M, Halfens, Jos, Wilson, Mark R, Beurskens, Anna J, Masters, Rich S W
Published in PloS one (26.06.2014)
Published in PloS one (26.06.2014)
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Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: implications for combination therapy
Da Roit, Fabio, Engelberts, Patrick J, Taylor, Ronald P, Breij, Esther C W, Gritti, Giuseppe, Rambaldi, Alessandro, Introna, Martino, Parren, Paul W H I, Beurskens, Frank J, Golay, Josée
Published in Haematologica (Roma) (01.01.2015)
Published in Haematologica (Roma) (01.01.2015)
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Complement Is Activated by IgG Hexamers Assembled at the Cell Surface
Diebolder, Christoph A., Beurskens, Frank J., de Jong, Rob N., Koning, Roman I., Strumane, Kristin, Lindorfer, Margaret A., Voorhorst, Marleen, Ugurlar, Deniz, Rosati, Sara, Heck, Albert J. R., van de Winkel, Jan G. J., Wilson, Ian A., Koster, Abraham J., Taylor, Ronald P., Saphire, Erica Ollmann, Burton, Dennis R., Schuurman, Janine, Gros, Piet, Parren, Paul W. H. I.
Published in Science (American Association for the Advancement of Science) (14.03.2014)
Published in Science (American Association for the Advancement of Science) (14.03.2014)
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Parents’ Perceptions: Environments and the Contextual Strategies of Parents to Support the Participation of Children and Adolescents with Autism Spectrum Disorder—A Descriptive Population-Based Study from Switzerland
Krieger, Beate, Moser, Albine, Morgenthaler, Thomas, Beurskens, Anna J. H. M., Piškur, Barbara
Published in Journal of autism and developmental disorders (01.03.2024)
Published in Journal of autism and developmental disorders (01.03.2024)
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Unraveling the Macromolecular Pathways of IgG Oligomerization and Complement Activation on Antigenic Surfaces
Strasser, Jürgen, de Jong, Rob N, Beurskens, Frank J, Wang, Guanbo, Heck, Albert J. R, Schuurman, Janine, Parren, Paul W. H. I, Hinterdorfer, Peter, Preiner, Johannes
Published in Nano letters (10.07.2019)
Published in Nano letters (10.07.2019)
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Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement
Ugurlar, Deniz, Howes, Stuart C, de Kreuk, Bart-Jan, Koning, Roman I, de Jong, Rob N, Beurskens, Frank J, Schuurman, Janine, Koster, Abraham J, Sharp, Thomas H, Parren, Paul W H I, Gros, Piet
Published in Science (American Association for the Advancement of Science) (16.02.2018)
Published in Science (American Association for the Advancement of Science) (16.02.2018)
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Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen
Wang, Guanbo, de Jong, Rob N., van den Bremer, Ewald T.J., Beurskens, Frank J., Labrijn, Aran F., Ugurlar, Deniz, Gros, Piet, Schuurman, Janine, Parren, Paul W.H.I., Heck, Albert J.R.
Published in Molecular cell (07.07.2016)
Published in Molecular cell (07.07.2016)
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Weak Fragment Crystallizable (Fc) Domain Interactions Drive the Dynamic Assembly of IgG Oligomers upon Antigen Recognition
Strasser, Jürgen, de Jong, Rob N, Beurskens, Frank J, Schuurman, Janine, Parren, Paul W. H. I, Hinterdorfer, Peter, Preiner, Johannes
Published in ACS nano (24.03.2020)
Published in ACS nano (24.03.2020)
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Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody
Gulati, Sunita, Beurskens, Frank J, de Kreuk, Bart-Jan, Roza, Marcel, Zheng, Bo, DeOliveira, Rosane B, Shaughnessy, Jutamas, Nowak, Nancy A, Taylor, Ronald P, Botto, Marina, He, Xianbao, Ingalls, Robin R, Woodruff, Trent M, Song, Wen-Chao, Schuurman, Janine, Rice, Peter A, Ram, Sanjay
Published in PLoS biology (19.06.2019)
Published in PLoS biology (19.06.2019)
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Fried phenotype of frailty: cross-sectional comparison of three frailty stages on various health domains
Op het Veld, Linda P M, van Rossum, Erik, Kempen, Gertrudis I J M, de Vet, Henrica C W, Hajema, KlaasJan, Beurskens, Anna J H M
Published in BMC geriatrics (09.07.2015)
Published in BMC geriatrics (09.07.2015)
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CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering
Oostindie, Simone C, van der Horst, Hilma J, Lindorfer, Margaret A, Cook, Erika M, Tupitza, Jillian C, Zent, Clive S, Burack, Richard, VanDerMeid, Karl R, Strumane, Kristin, Chamuleau, Martine E D, Mutis, Tuna, de Jong, Rob N, Schuurman, Janine, Breij, Esther C W, Beurskens, Frank J, Parren, Paul W H I, Taylor, Ronald P
Published in Haematologica (Roma) (01.09.2019)
Published in Haematologica (Roma) (01.09.2019)
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Effect of transfusion of fresh frozen plasma on parameters of endothelial condition and inflammatory status in non-bleeding critically ill patients: a prospective substudy of a randomized trial
Straat, Marleen, Müller, Marcella C A, Meijers, Joost C M, Arbous, Mendi S, Spoelstra-de Man, Angelique M E, Beurskens, Charlotte J P, Vroom, Margreeth B, Juffermans, Nicole P
Published in Critical care (London, England) (15.04.2015)
Published in Critical care (London, England) (15.04.2015)
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Agnostic B cell selection approach identifies antibodies against K. pneumoniae that synergistically drive complement activation
van der Lans, Sjors P. A., Bardoel, Bart W., Ruyken, Maartje, de Haas, Carla J. C., Baijens, Stan, Muts, Remy M., Scheepmaker, Lisette M., Aerts, Piet C., van ’t Wout, Marije F. L., Preiner, Johannes, Marijnissen, Renoud J., Schuurman, Janine, Beurskens, Frank J., Kerkman, Priscilla F., Rooijakkers, Suzan H. M.
Published in Nature communications (16.09.2024)
Published in Nature communications (16.09.2024)
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Monoclonal antibodies effectively potentiate complement activation and phagocytosis of Staphylococcus epidermidis in neonatal human plasma
de Vor, Lisanne, Beudeker, Coco R, Flier, Anne, Scheepmaker, Lisette M, Aerts, Piet C, Vijlbrief, Daniel C, Bekker, Mireille N, Beurskens, Frank J, van Kessel, Kok P M, de Haas, Carla J C, Rooijakkers, Suzan H M, van der Flier, Michiel
Published in Frontiers in immunology (29.07.2022)
Published in Frontiers in immunology (29.07.2022)
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Loss of CD20 and bound CD20 antibody from opsonized B cells occurs more rapidly because of trogocytosis mediated by Fc receptor-expressing effector cells than direct internalization by the B cells
Beum, Paul V, Peek, Elizabeth M, Lindorfer, Margaret A, Beurskens, Frank J, Engelberts, Patrick J, Parren, Paul W H I, van de Winkel, Jan G J, Taylor, Ronald P
Published in The Journal of immunology (1950) (15.09.2011)
Published in The Journal of immunology (1950) (15.09.2011)
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Promoting Fc-Fc interactions between anti-capsular antibodies provides strong immune protection against Streptococcus pneumoniae
Aguinagalde Salazar, Leire, den Boer, Maurits A, Castenmiller, Suzanne M, Zwarthoff, Seline A, de Haas, Carla, Aerts, Piet C, Beurskens, Frank J, Schuurman, Janine, Heck, Albert J R, van Kessel, Kok, Rooijakkers, Suzan H M
Published in eLife (22.03.2023)
Published in eLife (22.03.2023)
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Parents' perceptions: Participation patterns and desires for change for children and adolescents with autism spectrum disorder—A descriptive population‐based study from Switzerland
Krieger, Beate, Piškur, Barbara, Beurskens, Anna J. H. M., Moser, Albine
Published in Child : care, health & development (01.01.2024)
Published in Child : care, health & development (01.01.2024)
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How to support a co-creative research approach in order to foster impact. The development of a Co-creation Impact Compass for healthcare researchers
van Dijk-de Vries, Anneke, Stevens, Anita, van der Weijden, Trudy, Beurskens, Anna J H M
Published in PloS one (12.10.2020)
Published in PloS one (12.10.2020)
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