Identification of the Clinical Candidate PF-07284890 (ARRY-461), a Highly Potent and Brain Penetrant BRAF Inhibitor for the Treatment of Cancer
Ren, Li, Moreno, David, Baer, Brian R., Barbour, Patrick, Bettendorf, Tanna, Bouhana, Karyn, Brown, Karin, Brown, Suzy A., Fell, Jay B., Hartley, Dylan P., Hicken, Erik J., Laird, Ellen R., Lee, Patrice, McCown, Joseph, Otten, Jennifer N., Prigaro, Brett, Wallace, Ross, Kahn, Dean
Published in Journal of medicinal chemistry (08.08.2024)
Published in Journal of medicinal chemistry (08.08.2024)
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Journal Article
Abstract PO3-26-02: Identification of a novel, brain penetrant, EGFR sparing, ErbB2 inhibitor with activity against oncogenic ErbB2 mutations
Chicarelli, Mark J., Arwood-Levine, Ben, Bettendorf, Tanna, Bouhana, Karyn, Brizendine, Richard, Cable, LouAnn, Crow, Michelle, Fell, Brad, Fischer, John, Fulton, Jennifer, Guarnieri, Anna, Hillman, Madison, Jalluri, Ravi, Krischlunas, Daniel, Koch, Keith, Kumar, Vijay, Malinky, Cori, Rieger, Rob, Robinson, John, Stunkard, Lee, Sullivan, Francis, Turton, Roy, Vine, Logan, Winski, Shannon, Zhou, Yeyun
Published in Cancer research (Chicago, Ill.) (02.05.2024)
Published in Cancer research (Chicago, Ill.) (02.05.2024)
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BRAF-관련 질환 및 장애의 치료를 위한 4-옥소-3,4-다이하이드로퀸아졸린온 화합물
LAIRD ELLEN RUTH, BETTENDORF TANNA MARIE, REN LI, DOERNER BARBOUR PATRICK MICHAEL, KAHN DEAN RUSSELL, KELLUM ALEX ANDREW, MORENO DAVID AUSTIN
Year of Publication 09.02.2023
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Year of Publication 09.02.2023
Patent
Abstract 4486: Characterization of a novel mutant selective, EGFR sparing, ErbB2 inhibitor with activity across activating mutations in systemic and CNS tumors
Fulton, Jennifer, Bettendorf, Tanna, Blandon, Abiezer, Bouhana, Karyn, Brizendine, Richard K., Cable, LouAnn, Chicarelli, Mark J., Crow, Michelle, Fell, Brad, Fischer, John, Guarnieri, Anna, Hillman, Madison, Jalluri, Ravi, Kumar, Vijay, Malinky, Cori A., Rieger, Rob, Robinson, John, Stunkard, Lee, Sullivan, Francis, Trujillo, John I., Winski, Shannon, Zhou, Yeyun
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
ERBB2 INHIBITORS
BETTENDORF, Tanna, MALINKY, Cori A, CHATTERJEE, Payal, FISCHER, John, VINE, Logan E, FULTON, Jennifer, JALLURI, Ravi Kumar, CHICARELLI, Mark J, SALITURO, Leah J, FELL, Jay B
Year of Publication 17.10.2024
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Year of Publication 17.10.2024
Patent
4-oxo-3,4-dihydroquinazolinon compounds for the treatment of BRAF-associated diseases and disorders
DOERNER BARBOUR, Patrick Michael, BETTENDORF, Tanna Marie, LAIRD, Ellen Ruth, REN, Li, KELLUM, Alex Andrew, MORENO, David Austin, KAHN, Dean Russell
Year of Publication 02.05.2024
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Year of Publication 02.05.2024
Patent
ERK PROTEIN KINASE INHIBITORS
SMITH, Alexandra Nicole, HINKLIN, Ronald Jay, BETTENDORF, Tanna Marie, MCNULTY, Oren Teague, WICKERSHAM, Kyle Adam, BACKOS, Donald Sanford, POLITES, Viktor Christian, COOK, Adam Wade, MORENO, David Austin, GAUDINO, John Joseph, KAHN, Dean Russell
Year of Publication 24.10.2024
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Year of Publication 24.10.2024
Patent
4-OXO-3,4-DIHYDROQUINAZOLINON COMPOUNDS FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS
DOERNER BARBOUR, Patrick Michael, BETTENDORF, Tanna Marie, LAIRD, Ellen Ruth, REN, Li, KELLUM, Alex Andrew, MORENO, David Austin, KAHN, Dean Russell
Year of Publication 12.04.2023
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Year of Publication 12.04.2023
Patent
4-oxo-3,4-dihydroquinazolinon compounds for the treatment of BRAF-associated diseases and disorders
DOERNER BARBOUR, Patrick Michael, BETTENDORF, Tanna Marie, LAIRD, Ellen Ruth, REN, Li, KELLUM, Alex Andrew, MORENO, David Austin, KAHN, Dean Russell
Year of Publication 22.12.2022
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Year of Publication 22.12.2022
Patent
COMPOUNDS FOR FGFRS INHIBITORS
BETTENDORF, Tanna, CHATTERJEE, Payal, FULTON, Jennifer, SMITH, Aaron Christopher, DAHLKE, Joshua, MALINKY, Cori A, SCAGGS, Toya D, RODRIGUEZ, Martha E, MEJIA, Macedonio J, ROBINSON, John E, FISCHER, John P, NEWHOUSE, Bradley J, CHICARELLI, Mark Joseph, FELL, Jay Bradford, VINE, Logan E, RIEGER, Robert A, JALLURI, Ravi Kumar, SALITURO, Leah J
Year of Publication 15.08.2024
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Year of Publication 15.08.2024
Patent
COMPOUNDS FOR FGFRS INHIBITORS
Robinson, John E, Smith, Aaron Christopher, Fulton, Jennifer, Fischer, John P, Salituro, Leah J, Scaggs, Toya D, Vine, Logan E, Mejia, Macedonio J, Rodriguez, Martha E, Newhouse, Bradley J, Bettendorf, Tanna, Chicarelli, Mark Joseph, Chatterjee, Payal, Dahlke, Joshua, Rieger, Robert A, Jalluri, Ravi Kumar, Fell, Jay Bradford, Malinky, Cori A
Year of Publication 15.08.2024
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Year of Publication 15.08.2024
Patent
COMPOUNDS FOR FGFRS INHIBITORS
BETTENDORF, Tanna, CHATTERJEE, Payal, FULTON, Jennifer, SMITH, Aaron Christopher, DAHLKE, Joshua, MALINKY, Cori A, SCAGGS, Toya D, RODRIGUEZ, Martha E, MEJIA, Macedonio J, ROBINSON, John E, FISCHER, John P, NEWHOUSE, Bradley J, CHICARELLI, Mark Joseph, FELL, Jay Bradford, VINE, Logan E, RIEGER, Robert A, JALLURI, Ravi Kumar, SALITURO, Leah J
Year of Publication 18.07.2024
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Year of Publication 18.07.2024
Patent
4-OXO-3,4-DIHYDROQUINAZOLINON COMPOUNDS FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS
KELLUM, ALEX ANDREW, KAHN, DEAN RUSSELL, BETTENDORF, TANNA MARIE, LAIRD, ELLEN RUTH, REN, LI, DOERNER BARBOUR, PATRICK MICHAEL, MORENO, DAVID AUSTIN
Year of Publication 16.12.2021
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Year of Publication 16.12.2021
Patent
4-OXO-3,4-DIHYDROQUINAZOLINON COMPOUNDS FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS
DOERNER BARBOUR, Patrick Michael, BETTENDORF, Tanna Marie, LAIRD, Ellen Ruth, REN, Li, KELLUM, Alex Andrew, MORENO, David Austin, KAHN, Dean Russell
Year of Publication 16.12.2021
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Year of Publication 16.12.2021
Patent
COMPUESTOS DE 4-OXO-3,4-DIHIDROQUINAZOLINONA PARA EL TRATAMIENTO DE ENFERMEDADES Y TRASTORNOS ASOCIADOS A BRAF
DOERNER BARBOUR, Patrick Michael, BETTENDORF, Tanna Marie, LAIRD, Ellen Ruth, REN, Li, KELLUM, Alex Andrew, MORENO, David Austin, KAHN, Dean Russell
Year of Publication 28.02.2023
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Year of Publication 28.02.2023
Patent