Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2
Clark, Michael P, Ledeboer, Mark W, Davies, Ioana, Byrn, Randal A, Jones, Steven M, Perola, Emanuele, Tsai, Alice, Jacobs, Marc, Nti-Addae, Kwame, Bandarage, Upul K, Boyd, Michael J, Bethiel, Randy S, Court, John J, Deng, Hongbo, Duffy, John P, Dorsch, Warren A, Farmer, Luc J, Gao, Huai, Gu, Wenxin, Jackson, Katrina, Jacobs, Dylan H, Kennedy, Joseph M, Ledford, Brian, Liang, Jianglin, Maltais, François, Murcko, Mark, Wang, Tiansheng, Wannamaker, M. Woods, Bennett, Hamilton B, Leeman, Joshua R, McNeil, Colleen, Taylor, William P, Memmott, Christine, Jiang, Min, Rijnbrand, Rene, Bral, Christopher, Germann, Ursula, Nezami, Azin, Zhang, Yuegang, Salituro, Francesco G, Bennani, Youssef L, Charifson, Paul S
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
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Discovery of Novel, Orally Bioavailable β‑Amino Acid Azaindole Inhibitors of Influenza PB2
Farmer, Luc J., Clark, Michael P., Boyd, Michael J., Perola, Emanuele, Jones, Steven M., Tsai, Alice, Jacobs, Marc D., Bandarage, Upul K., Ledeboer, Mark W., Wang, Tiansheng, Deng, Hongbo, Ledford, Brian, Gu, Wenxin, Duffy, John P., Bethiel, Randy S., Shannon, Dean, Byrn, Randal A., Leeman, Joshua R., Rijnbrand, Rene, Bennett, Hamilton B., O’Brien, Colleen, Memmott, Christine, Nti-Addae, Kwame, Bennani, Youssef L., Charifson, Paul S.
Published in ACS medicinal chemistry letters (09.02.2017)
Published in ACS medicinal chemistry letters (09.02.2017)
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INHIBITORS OF INFLUENZA VIRUSES REPLICATION
GU WENXIN, FARMER LUC J, SALITURO FRANCESCO G, LEDFORD BRIAN, KWONG ANN DAK-YEE, JIANG MIN, II CHOU, M WOODS WANNAMAKER, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, CHARIFSON PAUL S, JONES STEVEN, BETHIEL RANDY S, MALTAIS FRANCOIS, JOSEPH M KENNEDY, DYLAN H JACOBS, URSULA A GERMANN, DENG HONGBO, EMANUELE PEROLA, UPUL K BANDARAGE, BYRN RANDAL, LIN CHAO, COURT JOHN J, IOANA DAVIES, DUFFY JOHN P, WANG TIANSHENG
Year of Publication 23.01.2020
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Year of Publication 23.01.2020
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INHIBITORS OF INFLUENZA VIRUS REPLICATION
BETHIEL RANDY S, GU WENXIN, FARMER LUC J, LEDFORD BRIAN, MALTAIS FRANCOIS, JOSEPH M KENNEDY, DENG HONGBO, EMANUELE PEROLA, UPUL K BANDARAGE, MICHEAL J BOYD, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, IOANA DAVIES, DUFFY JOHN P, CHARIFSON PAUL S, WANG TIANSHENG
Year of Publication 19.04.2018
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Year of Publication 19.04.2018
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Inhibitors of influenza viruses replication
GU WENXIN, BANDARAGE UPUL K, PEROLA EMANUELE, SALITURO FRANCESCO G, LEDFORD BRIAN, JACOBS DYLAN H, JIANG MIN, GERMANN URSULA A, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, JONES STEVEN, BETHIEL RANDY S, DRUTU IOANA, KENNEDY JOSEPH M, KWONG ANN DAK YEE, ZHOU YI, MALTAIS FRANCOIS, DENG HONGBO, FARMER LUC, BYRN RANDAL, LIN CHAO, COURT JOHN J, DUFFY JOHN P, WANNAMAKER M. WOODS, WANG TIANSHENG, CHARIFSON PAUL
Year of Publication 04.10.2018
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Year of Publication 04.10.2018
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INHIBITORS OF INFLUENZA VIRUS REPLICATION
GU WENXIN, FARMER LUC J, SALITURO FRANCESCO G, LEDFORD BRIAN, KWONG ANN DAK-YEE, JIANG MIN, II CHOU, M WOODS WANNAMAKER, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, CHARIFSON PAUL S, JONES STEVEN, BETHIEL RANDY S, MALTAIS FRANCOIS, JOSEPH M KENNEDY, DYLAN H JACOBS, URSULA A GERMANN, DENG HONGBO, EMANUELE PEROLA, UPUL K BANDARAGE, BYRN RANDAL, LIN CHAO, COURT JOHN J, IOANA DAVIES, DUFFY JOHN P, WANG TIANSHENG
Year of Publication 11.01.2018
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Year of Publication 11.01.2018
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Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases
Farmer, Luc J, Ledeboer, Mark W, Hoock, Thomas, Arnost, Michael J, Bethiel, Randy S, Bennani, Youssef L, Black, James J, Brummel, Christopher L, Chakilam, Ananthsrinivas, Dorsch, Warren A, Fan, Bin, Cochran, John E, Halas, Summer, Harrington, Edmund M, Hogan, James K, Howe, David, Huang, Hui, Jacobs, Dylan H, Laitinen, Leena M, Liao, Shengkai, Mahajan, Sudipta, Marone, Valerie, Martinez-Botella, Gabriel, McCarthy, Pamela, Messersmith, David, Namchuk, Mark, Oh, Luke, Penney, Marina S, Pierce, Albert C, Raybuck, Scott A, Rugg, Arthur, Salituro, Francesco G, Saxena, Kumkum, Shannon, Dean, Shlyakter, Dina, Swenson, Lora, Tian, Shi-Kai, Town, Christopher, Wang, Jian, Wang, Tiansheng, Wannamaker, M. Woods, Winquist, Raymond J, Zuccola, Harmon J
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Inhibitors of influenza viruses replication
GU WENXIN, BANDARAGE UPUL K, PEROLA EMANUELE, SALITURO FRANCESCO G, LEDFORD BRIAN, JACOBS DYLAN H, JIANG MIN, GERMANN URSULA A, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, JONES STEVEN, BETHIEL RANDY S, DRUTU IOANA, KENNEDY JOSEPH M, KWONG ANN DAK YEE, ZHOU YI, MALTAIS FRANCOIS, DENG HONGBO, FARMER LUC, BYRN RANDAL, LIN CHAO, COURT JOHN J, DUFFY JOHN P, WANNAMAKER M. WOODS, WANG TIANSHENG, CHARIFSON PAUL
Year of Publication 08.02.2017
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Year of Publication 08.02.2017
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INHIBITORS OF INFLUENZA VIRUS REPLICATION
BETHIEL RANDY S, GU WENXIN, FARMER LUC J, LEDFORD BRIAN, MALTAIS FRANCOIS, JOSEPH M KENNEDY, DENG HONGBO, EMANUELE PEROLA, UPUL K BANDARAGE, MICHEAL J BOYD, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, IOANA DAVIES, DUFFY JOHN P, CHARIFSON PAUL S, WANG TIANSHENG
Year of Publication 07.07.2016
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Year of Publication 07.07.2016
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INHIBITORS OF INFLUENZA VIRUS REPLICATION
GU WENXIN, FARMER LUC J, SALITURO FRANCESCO G, LEDFORD BRIAN, KWONG ANN DAK-YEE, JIANG MIN, II CHOU, M WOODS WANNAMAKER, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, CHARIFSON PAUL S, JONES STEVEN, BETHIEL RANDY S, MALTAIS FRANCOIS, JOSEPH M KENNEDY, DYLAN H JACOBS, URSULA A GERMANN, DENG HONGBO, EMANUELE PEROLA, UPUL K BANDARAGE, BYRN RANDAL, LIN CHAO, COURT JOHN J, IOANA DAVIES, DUFFY JOHN P, WANG TIANSHENG
Year of Publication 08.12.2016
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Year of Publication 08.12.2016
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INHIBITORS OF INFLUENZA VIRUSES REPLICATION
GU WENXIN, FARMER LUC J, SALITURO FRANCESCO G, LEDFORD BRIAN, KWONG ANN DAK-YEE, JIANG MIN, II CHOU, M WOODS WANNAMAKER, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, CHARIFSON PAUL S, JONES STEVEN, BETHIEL RANDY S, MALTAIS FRANCOIS, JOSEPH M KENNEDY, DYLAN H JACOBS, URSULA A GERMANN, DENG HONGBO, EMANUELE PEROLA, UPUL K BANDARAGE, BYRN RANDAL, LIN CHAO, COURT JOHN J, IOANA DAVIES, DUFFY JOHN P, WANG TIANSHENG
Year of Publication 26.02.2015
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Year of Publication 26.02.2015
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INHIBITORS OF INFLUENZA VIRUSES REPLICATION
GU WENXIN, FARMER LUC J, SALITURO FRANCESCO G, LEDFORD BRIAN, KWONG ANN DAK-YEE, JIANG MIN, II CHOU, M WOODS WANNAMAKER, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, CHARIFSON PAUL S, JONES STEVEN, BETHIEL RANDY S, MALTAIS FRANCOIS, JOSEPH M KENNEDY, DYLAN H JACOBS, URSULA A GERMANN, DENG HONGBO, EMANUELE PEROLA, UPUL K BANDARAGE, BYRN RANDAL, LIN CHAO, COURT JOHN J, IOANA DAVIES, DUFFY JOHN P, WANG TIANSHENG
Year of Publication 19.02.2015
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Year of Publication 19.02.2015
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INHIBITORS OF INFLUENZA VIRUSES REPLICATION
BETHIEL RANDY S, GU WENXIN, BANDARAGE UPUL K, KENNEDY JOSEPH M, FARMER LUC J, PEROLA EMANUELE, LEDFORD BRIAN, MALTAIS FRANCOIS, DENG HONGBO, BOYD MICHAEL J, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, DUFFY JOHN P, CHARIFSON PAUL S, WANG TIANSHENG, DAVIES IOANA
Year of Publication 28.05.2014
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Year of Publication 28.05.2014
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INHIBITORS OF INFLUENZA VIRUSES REPLICATION
GU WENXIN, BANDARAGE UPUL K, PEROLA EMANUELE, LEDFORD BRIAN, JACOBS DYLAN H, JIANG MIN, GERMANN URSULA A, CLARK MICHAEL P, GAO HUAI, LEDEBOER MARK W, JONES STEVEN, BETHIEL RANDY S, DRUTU IOANA, KENNEDY JOSEPH M, ZHOU YI, MALTAIS FRANCOIS, DENG HONGBO, FARMER LUC, BYRN RANDAL, LIN CHAO, COURT JOHN J, DUFFY JOHN P, WANNAMAKER M. WOODS, WANG TIANSHENG, CHARIFSON PAUL
Year of Publication 04.09.2012
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Year of Publication 04.09.2012
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UREA DERIVATIVES AS INHIBITORS OF IMPDH ENZYME
BEMIS GUY W, NOVAK PERRY M, BETHIEL RANDY S, RONKIN STEVEN M, SAUNDERS JEFFREY O, ARMISTEAD DAVID M, BADIA MICHAEL C, FRANK CATHARINE A
Year of Publication 15.02.2000
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Year of Publication 15.02.2000
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JACOBS, Dylan H, WANG, Tiansheng, WANNAMAKER, Woods M, LEDFORD, Brian, COURT, John J, KENNEDY, Joseph M, LIN, Chao, GERMANN, Ursula A, SALITURO, Francesco G, CLARK, Michael P, BANDARAGE, Upul K, BETHIEL, Randy S, DUFFY, John. P, GAO, Huai, MALTAIS, Francois, JONES, Steven, KWONG, Ann Dak-Yee, GU, Wenxin, PEROLA, Emanuele, FARMER, Luc, BYRN, Randal, DENG, Hongbo, ZHOU, Yi, CHARIFSON, Paul, JIANG, Min, LEDEBOER, Mark W, DRUTU, Ioana
Year of Publication 01.12.2021
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Year of Publication 01.12.2021
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INHIBITORS OF INFLUENZA VIRUSES REPLICATION
Gu, Wenxin, Deng, Hongbo, Wang, Tiansheng, Bandarage, Upal K, Bethiel, Randy S, Kennedy, Joseph M, Ledford, Brain, Charifson, Paul S, Ledeboer, Mark W, Clark, Michael P, Perola, Emanuele, Boyd, Michael J, Farmer, Luc J, Duffy, John P, Maltais, Francois, Davies, Ioana, Gao, Huai
Year of Publication 11.02.2021
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Year of Publication 11.02.2021
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Inhibitors of influenza viruses replication
Gu, Wenxin, Deng, Hongbo, Wang, Tiansheng, Bethiel, Randy S, Kennedy, Joseph M, Charifson, Paul S, Ledeboer, Mark W, Clark, Michael P, Ledford, Brian, Perola, Emanuele, Bandarage, Upul K, Boyd, Michael J, Farmer, Luc J, Duffy, John P, Maltais, Francois, Davies, Ioana, Gao, Huai
Year of Publication 29.12.2020
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Year of Publication 29.12.2020
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INHIBITORS OF INFLUENZA VIRUSES REPLICATION
KENNEDY, JOSEPH M, FARMER, LUC J, PEROLA, EMANUELE, DUFFY, JOHN P, CHARIFSON, PAUL S, BANDARAGE, UPUL K, CLARK, MICHAEL P, GAO, HUAI, DAVIES, IOANA, GU, WENXIN, WANG, TIANSHENG, LEDEBOER, MARK W, MALTAIS, FRANCOIS, BOYD, MICHAEL J, LEDFORD, BRIAN, BETHIEL, RANDY S, DENG, HONGBO
Year of Publication 01.09.2020
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Year of Publication 01.09.2020
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