Binding of Tritiated Sildenafil, Tadalafil, or Vardenafil to the Phosphodiesterase-5 Catalytic Site Displays Potency, Specificity, Heterogeneity, and cGMP Stimulation
Blount, Mitsi A, Beasley, Alfreda, Zoraghi, Roya, Sekhar, Konjeti R, Bessay, Emmanuel P, Francis, Sharron H, Corbin, Jackie D
Published in Molecular pharmacology (01.07.2004)
Published in Molecular pharmacology (01.07.2004)
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Structural and Functional Features in Human PDE5A1 Regulatory Domain That Provide for Allosteric cGMP Binding, Dimerization, and Regulation
Zoraghi, Roya, Bessay, Emmanuel P., Corbin, Jackie D., Francis, Sharron H.
Published in The Journal of biological chemistry (25.03.2005)
Published in The Journal of biological chemistry (25.03.2005)
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A 46-Amino Acid Segment in Phosphodiesterase-5 GAF-B Domain Provides for High Vardenafil Potency over Sildenafil and Tadalafil and Is Involved in Phosphodiesterase-5 Dimerization
Blount, Mitsi A, Zoraghi, Roya, Ke, Hengming, Bessay, Emmanuel P, Corbin, Jackie D, Francis, Sharron H
Published in Molecular pharmacology (01.11.2006)
Published in Molecular pharmacology (01.11.2006)
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Phosphorylation of Isolated Human Phosphodiesterase-5 Regulatory Domain Induces an Apparent Conformational Change and Increases cGMP Binding Affinity
Francis, Sharron H., Bessay, Emmanuel P., Kotera, Jun, Grimes, Kennard A., Liu, Li, Thompson, W. Joseph, Corbin, Jackie D.
Published in The Journal of biological chemistry (06.12.2002)
Published in The Journal of biological chemistry (06.12.2002)
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Conversion of Phosphodiesterase-5 (PDE5) Catalytic Site to Higher Affinity by PDE5 Inhibitors
Blount, Mitsi A, Zoraghi, Roya, Bessay, Emmanuel P, Beasley, Alfreda, Francis, Sharron H, Corbin, Jackie D
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
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Phosphorylation Increases Affinity of the Phosphodiesterase-5 Catalytic Site for Tadalafil
Bessay, Emmanuel P, Blount, Mitsi A, Zoraghi, Roya, Beasley, Alfreda, Grimes, Kennard A, Francis, Sharron H, Corbin, Jackie D
Published in The Journal of pharmacology and experimental therapeutics (01.04.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2008)
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Phosphorylation of phosphodiesterase-5 is promoted by a conformational change induced by sildenafil, vardenafil, or tadalafil
Bessay, Emmanuel P, Zoraghi, Roya, Blount, Mitsi A, Grimes, Kennard A, Beasley, Alfreda, Francis, Sharron H, Corbin, Jackie D
Published in Frontiers in bioscience (01.01.2007)
Published in Frontiers in bioscience (01.01.2007)
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A Conserved Serine Juxtaposed to the Pseudosubstrate Site of Type I cGMP-dependent Protein Kinase Contributes Strongly to Autoinhibition and Lower cGMP Affinity
Busch, Jennifer L., Bessay, Emmanuel P., Francis, Sharron H., Corbin, Jackie D.
Published in The Journal of biological chemistry (13.09.2002)
Published in The Journal of biological chemistry (13.09.2002)
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Correlation of seasonal acclimatization in metabolic enzyme activity with preferred body temperature in the Eastern red spotted newt ( Notophthalmus viridescens viridescens)
Berner, Nancy J., Bessay, Emmanuel P.
Published in Comparative biochemistry and physiology. Part A, Molecular & integrative physiology (01.08.2006)
Published in Comparative biochemistry and physiology. Part A, Molecular & integrative physiology (01.08.2006)
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Negative feedback control of the nitric oxide/cGMP pathway in smooth muscle
Corbin, Jackie, Bessay, Emmanuel P, Blount, Mitsi A, Zoraghi, Roya, Morris, Gary Z, Weeks, James L, Ke, Hengming, Francis, Sharron H
Published in BMC pharmacology (25.07.2007)
Published in BMC pharmacology (25.07.2007)
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