Challenges in the development of an M-4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides
Tarr, James C., Wood, Michael R., Noetzel, Meredith J., Bertron, Jeanette L., Weiner, Rebecca L., Rodriguez, Alice L., Lamsal, Atin, Byers, Frank W., Chang, Sichen, Cho, Hyekyung P., Jones, Carrie K., Niswender, Colleen M., Wood, Michael W., Brandon, Nicholas J., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.07.2017)
Published in Bioorganic & medicinal chemistry letters (01.07.2017)
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Journal Article
DARK Classics in Chemical Neuroscience: Phencyclidine (PCP)
Bertron, Jeanette L, Seto, Mabel, Lindsley, Craig W
Published in ACS chemical neuroscience (17.10.2018)
Published in ACS chemical neuroscience (17.10.2018)
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Journal Article
Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels
Shao, Hao, Li, Xiaokai, Hayashi, Shigenari, Bertron, Jeanette L., Schwarz, Daniel M.C., Tang, Benjamin C., Gestwicki, Jason E.
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
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Journal Article
Formal Total Synthesis of Pericoannosin A
Fulton, Mark G, Bertron, Jeanette L, Reed, Carson W, Lindsley, Craig W
Published in Journal of organic chemistry (20.09.2019)
Published in Journal of organic chemistry (20.09.2019)
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Journal Article
A Novel M 1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity
Rook, Jerri M, Bertron, Jeanette L, Cho, Hyekyung P, Garcia-Barrantes, Pedro M, Moran, Sean P, Maksymetz, James T, Nance, Kellie D, Dickerson, Jonathan W, Remke, Daniel H, Chang, Sichen, Harp, Joel M, Blobaum, Anna L, Niswender, Colleen M, Jones, Carrie K, Stauffer, Shaun R, Conn, P Jeffrey, Lindsley, Craig W
Published in ACS chemical neuroscience (19.09.2018)
Published in ACS chemical neuroscience (19.09.2018)
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Journal Article
The discovery of VU0486846: steep SAR from a series of M-1 PAMs based on a novel benzomorpholine core
Bertron, Jeanette L., Cho, Hyekyung P., Garcia-Barrantes, Pedro M., Panarese, Joseph D., Salovich, James M., Nance, Kellie D., Engers, Darren W., Rook, Jerri M., Blobaum, Anna L., Niswender, Colleen M., Stauffer, Shaun R., Conn, P. Jeffrey, Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
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Journal Article
The discovery of VU0486846: steep SAR from a series of M1 PAMs based on a novel benzomorpholine core
Bertron, Jeanette L., Cho, Hyekyung P., Garcia-Barrantes, Pedro M., Panarese, Joseph D., Salovich, James M., Nance, Kellie D., Engers, Darren W., Rook, Jerri M., Blobaum, Anna L., Niswender, Colleen M., Stauffer, Shaun R., Conn, P. Jeffrey, Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
Published in Bioorganic & medicinal chemistry letters (01.07.2018)
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Journal Article
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides
Tarr, James C., Wood, Michael R., Noetzel, Meredith J., Bertron, Jeanette L., Weiner, Rebecca L., Rodriguez, Alice L., Lamsal, Atin, Byers, Frank W., Chang, Sichen, Cho, Hyekyung P., Jones, Carrie K., Niswender, Colleen M., Wood, Michael W., Brandon, Nicholas J., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.07.2017)
Published in Bioorganic & medicinal chemistry letters (01.07.2017)
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Journal Article
Discovery and Optimization of a Novel Series of Competitive and Central Nervous System-Penetrant Protease-Activated Receptor 4 (PAR4) Inhibitors
Bertron, Jeanette L, Duvernay, Matthew T, Mitchell, Sidnee G, Smith, Shannon T, Maeng, Jae G, Blobaum, Anna L, Davis, Dexter C, Meiler, Jens, Hamm, Heidi E, Lindsley, Craig W
Published in ACS chemical neuroscience (15.12.2021)
Published in ACS chemical neuroscience (15.12.2021)
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Journal Article
VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate
Engers, Darren W., Melancon, Bruce J., Gregro, Allison R., Bertron, Jeanette L., Bollinger, Sean R., Felts, Andrew S., Konkol, Leah C., Wood, Michael R., Bollinger, Katrina A., Luscombe, Vincent B., Rodriguez, Alice L., Jones, Carrie K., Bubser, Michael, Yohn, Samantha E., Wood, Michael W., Brandon, Nicholas J., Dugan, Mark E., Niswender, Colleen M., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (15.07.2019)
Published in Bioorganic & medicinal chemistry letters (15.07.2019)
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Journal Article
VU6005806/AZN-00016130, an advanced M-4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate
Engers, Darren W., Melancon, Bruce J., Gregro, Allison R., Bertron, Jeanette L., Bollinger, Sean R., Felts, Andrew S., Konkol, Leah C., Wood, Michael R., Bollinger, Katrina A., Luscombe, Vincent B., Rodriguez, Alice L., Jones, Carrie K., Bubser, Michael, Yohn, Samantha E., Wood, Michael W., Brandon, Nicholas J., Dugan, Mark E., Niswender, Colleen M., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (15.07.2019)
Published in Bioorganic & medicinal chemistry letters (15.07.2019)
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Journal Article
Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound
Bertron, Jeanette L., Ennis, Elizabeth A., Tarr, Christopher J., Wright, Jane, Dickerson, Jonathan W., Locuson, Charles W., Blobaum, Anna L., Rook, Jerri M., Blakely, Randy D., Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
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Journal Article
A Novel M1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity
Rook, Jerri M, Bertron, Jeanette L, Cho, Hyekyung P, Garcia-Barrantes, Pedro M, Moran, Sean P, Maksymetz, James T, Nance, Kellie D, Dickerson, Jonathan W, Remke, Daniel H, Chang, Sichen, Harp, Joel M, Blobaum, Anna L, Niswender, Colleen M, Jones, Carrie K, Stauffer, Shaun R, Conn, P. Jeffrey, Lindsley, Craig W
Published in ACS chemical neuroscience (19.09.2018)
Published in ACS chemical neuroscience (19.09.2018)
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Journal Article