Unlocking the secrets of the gatekeeper: Methods for stabilizing and crystallizing GPCRs
Bertheleme, Nicolas, Chae, Pil Seok, Singh, Shweta, Mossakowska, Danuta, Hann, Michael M., Smith, Kathrine J., Hubbard, Julia A., Dowell, Simon J., Byrne, Bernadette
Published in Biochimica et biophysica acta (01.11.2013)
Published in Biochimica et biophysica acta (01.11.2013)
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Journal Article
Arginine 199 and leucine 208 have key roles in the control of adenosine A2A receptor signalling function
Bertheleme, Nicolas, Strege, Annette, Bunting, Sorrel E, Dowell, Simon J, Byrne, Bernadette
Published in PloS one (03.03.2014)
Published in PloS one (03.03.2014)
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Journal Article
Heterologous expression of G-protein-coupled receptors in yeast
Bertheleme, Nicolas, Singh, Shweta, Dowell, Simon, Byrne, Bernadette
Published in Methods in enzymology (2015)
Published in Methods in enzymology (2015)
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Journal Article
Production of stable membrane proteins for the development of biologics
Duclos, Stephanie, Bertheleme, Nicolas, Yadav, Rahul, Hitchman, Richard, Singh, Shweta, Barker, John, Ullmann, Dirk
Published in Acta crystallographica. Section A, Foundations and advances (26.05.2017)
Published in Acta crystallographica. Section A, Foundations and advances (26.05.2017)
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Journal Article
The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist
Rimland, Joseph, Dunne, Angela, Hunjan, Suchete S., Sasse, Rosemary, Uings, Iain, Montanari, Dino, Caivano, Matilde, Shah, Poonam, Standing, David, Gray, David, Brown, David, Cairns, William, Trump, Ryan, Smith, Paul W., Bertheleme, Nicolas, D’Alessandro, Pier, Gul, Sheraz, Vimal, Mythily, Smith, David N., Watson, Stephen P.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Journal Article
Radioligand binding analysis as a tool for quality control of GPCR production for structural characterization: adenosine A(2a)R as a template for study
Singh, Shweta, Zhang, Minghao, Bertheleme, Nicolas, Kara, Elodie, Strange, Philip G, Byrne, Bernadette
Published in Current protocols in protein science (01.02.2012)
Published in Current protocols in protein science (01.02.2012)
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Journal Article
Purification of the human G protein-coupled receptor adenosine A(2a)R in a stable and functional form expressed in Pichia pastoris
Singh, Shweta, Zhang, Minghao, Bertheleme, Nicolas, Strange, Philip G, Byrne, Bernadette
Published in Current protocols in protein science (01.02.2012)
Published in Current protocols in protein science (01.02.2012)
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Journal Article
Tetrazole compounds as calcium channel blockers
Vile Sadie, Gleave Robert James, Bertheleme Nicolas, Hachisu Shuji, Ward Simon E, Beswick Paul
Year of Publication 05.09.2017
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Year of Publication 05.09.2017
Patent
TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS
GLEAVE ROBERT JAMES, VILE SADIE, BERTHELEME NICOLAS, WARD SIMON E, BESWICK PAUL, HACHISU SHUJI
Year of Publication 21.01.2016
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Year of Publication 21.01.2016
Patent
TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS
BESWICK, PAUL JOHN, VILE, SADIE, BERTHELEME, NICOLAS, GLEAVE, ROBERT JAMES, WARD, SIMON E, HACHISU, SHUJI
Year of Publication 29.10.2014
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Year of Publication 29.10.2014
Patent
TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS
BESWICK, PAUL JOHN, VILE, SADIE, BERTHELEME, NICOLAS, GLEAVE, ROBERT JAMES, WARD, SIMON E, HACHISU, SHUJI
Year of Publication 15.05.2013
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Year of Publication 15.05.2013
Patent
Compounds which potentiate the AMPA receptor and uses thereof in medicine
SCOTT JAQUELINE SANDRA, BERTHELEME NICOLAS, WARD SIMON E, CHAN WAI NGOR
Year of Publication 08.05.2012
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Year of Publication 08.05.2012
Patent
Compounds which potentiate the AMPA receptor and uses thereof in medicine
Bertheleme, Nicolas, Chan, Wai Ngor, Scott, Jaqueline Sandra, Ward, Simon E
Year of Publication 08.05.2012
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Year of Publication 08.05.2012
Patent
TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS
BESWICK, PAUL JOHN, VILE, SADIE, BERTHELEME, NICOLAS, GLEAVE, ROBERT JAMES, WARD, SIMON E, HACHISU, SHUJI
Year of Publication 12.01.2012
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Year of Publication 12.01.2012
Patent
Compounds which Potentiate the AMPA Receptor and Uses Thereof in Medicine
SCOTT JAQUELINE SANDRA, BERTHELEME NICOLAS, WARD SIMON E, CHAN WAI NGOR
Year of Publication 27.01.2011
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Year of Publication 27.01.2011
Patent