Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors
DiMauro, Erin F, Altmann, Stephen, Berry, Loren M, Bregman, Howard, Chakka, Nagasree, Chu-Moyer, Margaret, Bojic, Elma Feric, Foti, Robert S, Fremeau, Robert, Gao, Hua, Gunaydin, Hakan, Guzman-Perez, Angel, Hall, Brian E, Huang, Hongbing, Jarosh, Michael, Kornecook, Thomas, Lee, Josie, Ligutti, Joseph, Liu, Dong, Moyer, Bryan D, Ortuno, Daniel, Rose, Paul E, Schenkel, Laurie B, Taborn, Kristin, Wang, Jean, Wang, Yan, Yu, Violeta, Weiss, Matthew M
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
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Journal Article
Prediction of Vss from In Vitro Tissue-Binding Studies
BERRY, Loren M, ROBERTS, Jonathan, XUHAI BE, ZHIYANG ZHAO, LIN, Min-Hwa Jasmine
Published in Drug metabolism and disposition (01.01.2010)
Published in Drug metabolism and disposition (01.01.2010)
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Journal Article
PHARMACOKINETICS AND METABOLISM OF [14C]EPLERENONE AFTER ORAL ADMINISTRATION TO HUMANS
COOK, Chyung S, BERRY, Loren M, BIBLE, Roy H, HRIBAR, Jeremy D, HAJDU, Elisabeth, LIU, Norman W
Published in Drug metabolism and disposition (01.11.2003)
Published in Drug metabolism and disposition (01.11.2003)
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Journal Article
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity
Graceffa, Russell F, Boezio, Alessandro A, Able, Jessica, Altmann, Steven, Berry, Loren M, Boezio, Christiane, Butler, John R, Chu-Moyer, Margaret, Cooke, Melanie, DiMauro, Erin F, Dineen, Thomas A, Feric Bojic, Elma, Foti, Robert S, Fremeau, Robert T, Guzman-Perez, Angel, Gao, Hua, Gunaydin, Hakan, Huang, Hongbing, Huang, Liyue, Ilch, Christopher, Jarosh, Michael, Kornecook, Thomas, Kreiman, Charles R, La, Daniel S, Ligutti, Joseph, Milgram, Benjamin C, Lin, Min-Hwa Jasmine, Marx, Isaac E, Nguyen, Hanh N, Peterson, Emily A, Rescourio, Gwen, Roberts, John, Schenkel, Laurie, Shimanovich, Roman, Sparling, Brian A, Stellwagen, John, Taborn, Kristin, Vaida, Karina R, Wang, Jean, Yeoman, John, Yu, Violeta, Zhu, Dawn, Moyer, Bryan D, Weiss, Matthew M
Published in Journal of medicinal chemistry (27.07.2017)
Published in Journal of medicinal chemistry (27.07.2017)
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Journal Article
Dynamic modeling of cytochrome P450 inhibition in vitro: impact of inhibitor depletion on IC₅₀ shift
Berry, Loren M, Zhao, Zhiyang, Lin, Min-Hwa Jasmine
Published in Drug metabolism and disposition (01.07.2013)
Published in Drug metabolism and disposition (01.07.2013)
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Journal Article
Applications of parallel synthetic lead hopping and pharmacophore-based virtual screening in the discovery of efficient glycine receptor potentiators
Chakka, Nagasree, Andrews, Kristin L., Berry, Loren M., Bregman, Howard, Gunaydin, Hakan, Huang, Liyue, Guzman-Perez, Angel, Plant, Matthew H., Simard, Jeffrey R., Gingras, Jacinthe, DiMauro, Erin F.
Published in European journal of medicinal chemistry (08.09.2017)
Published in European journal of medicinal chemistry (08.09.2017)
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Journal Article
Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity
Graceffa, Russell F, Boezio, Alessandro A, Able, Jessica, Altmann, Steven, Berry, Loren M, Boezio, Christiane, Butler, John R, Chu-Moyer, Margaret, Cooke, Melanie, DiMauro, Erin F, Dineen, Thomas A, Feric Bojic, Elma, Foti, Robert S, Fremeau, Jr, Robert T, Guzman-Perez, Angel, Gao, Hua, Gunaydin, Hakan, Huang, Hongbing, Huang, Liyue, Ilch, Christopher, Jarosh, Michael, Kornecook, Thomas, Kreiman, Charles R, La, Daniel S, Ligutti, Joseph, Milgram, Benjamin C, Lin, Min-Hwa Jasmine, Marx, Isaac E, Nguyen, Hanh N, Peterson, Emily A, Rescourio, Gwen, Roberts, John, Schenkel, Laurie, Shimanovich, Roman, Sparling, Brian A, Stellwagen, John, Taborn, Kristin, Vaida, Karina R, Wang, Jean, Yeoman, John, Yu, Violeta, Zhu, Dawn, Moyer, Bryan D, Weiss, Matthew M
Published in Journal of medicinal chemistry (27.07.2017)
Published in Journal of medicinal chemistry (27.07.2017)
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Journal Article
Impact of hydrolysis-mediated clearance on the pharmacokinetics of novel anaplastic lymphoma kinase inhibitors
Teffera, Yohannes, Berry, Loren M, Brake, Rachael L, Lewis, Richard T, Saffran, Douglas C, Moore, Earl, Liu, Jingzhou, Zhao, Zhiyang
Published in Drug metabolism and disposition (01.01.2013)
Published in Drug metabolism and disposition (01.01.2013)
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Journal Article
Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity
Munro, Thomas A, Berry, Loren M, Van't Veer, Ashlee, Béguin, Cécile, Carroll, F Ivy, Zhao, Zhiyang, Carlezon, Jr, William A, Cohen, Bruce M
Published in BMC pharmacology (29.05.2012)
Published in BMC pharmacology (29.05.2012)
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Journal Article
Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective Na(V)1.7 Inhibitors
DiMauro, Erin F., Altmann, Stephen, Berry, Loren M., Bregman, Howard, Chakka, Nagasree, Chu-Moyer, Margaret, Bojic, Elma Feric, Foti, Robert S., Fremeau, Robert, Gao, Hua, Gunaydin, Hakan, Guzman-Perez, Angel, Hall, Brian E., Huang, Hongbing, Jarosh, Michael, Korneook, Thomas, Lee, Josie, Ligutti, Joseph, Liu, Dong, Moyer, Bryan D., Ortuno, Daniel, Rose, Paul E., Schenkel, Laurie B., Taborn, Kristin, Wang, Jean, Wang, Yan, Yu, Violeta, Weiss, Matthew M.
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
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Journal Article
Prediction of V ss from In Vitro Tissue-Binding Studies
Berry, Loren M., Roberts, Jonathan, Be, Xuhai, Zhao, Zhiyang, Lin, Min-Hwa Jasmine
Published in Drug metabolism and disposition (01.01.2010)
Published in Drug metabolism and disposition (01.01.2010)
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Journal Article
Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective Na V 1.7 Inhibitors
DiMauro, Erin F., Altmann, Stephen, Berry, Loren M., Bregman, Howard, Chakka, Nagasree, Chu-Moyer, Margaret, Bojic, Elma Feric, Foti, Robert S., Fremeau, Robert, Gao, Hua, Gunaydin, Hakan, Guzman-Perez, Angel, Hall, Brian E., Huang, Hongbing, Jarosh, Michael, Kornecook, Thomas, Lee, Josie, Ligutti, Joseph, Liu, Dong, Moyer, Bryan D., Ortuno, Daniel, Rose, Paul E., Schenkel, Laurie B., Taborn, Kristin, Wang, Jean, Wang, Yan, Yu, Violeta, Weiss, Matthew M.
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
Get full text
Journal Article