The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system
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Published in Immunological reviews (01.07.2014)
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ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease
Nordström, Eva, Eriksson, Fredrik, Sigvardson, Jessica, Johannesson, Malin, Kasrayan, Alex, Jones-Kostalla, Martina, Appelkvist, Paulina, Söderberg, Linda, Nygren, Patrik, Blom, Magdalena, Rachalski, Adeline, Nordenankar, Karin, Zachrisson, Olof, Amandius, Ebba, Osswald, Gunilla, Moge, Mikael, Ingelsson, Martin, Bergström, Joakim, Lannfelt, Lars, Möller, Christer, Giorgetti, Marco, Fälting, Johanna
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Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair ltp via NMDA-receptor activation
de Oliveira Diógenes Nogueira, Maria José, Dias, Raquel, Rombo, Diogo, Vicente Miranda, Hugo, Maiolino, Francesca, Guerreiro, Patrícia, Nasstrom, Thomas, Franquelim, Henri, Oliveira, Luís M.A., Castanho, Miguel, Lannfelt, Lars, Bergstrom, Joakim, Ingelsson, Martin, Quintas, Alexandre, Sebastião, Ana M, Lopes, Luisa, Outeiro, Tiago
Published in The Journal of neuroscience (22.08.2012)
Published in The Journal of neuroscience (22.08.2012)
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Murine Butyrophilin-Like 1 and BtnI6 Form Heteromeric Complexes in Small Intestinal Epithelial Cells and Promote Proliferation of Local T Lymphocytes
Lebrero-Fernandez, Cristina, Bergström, Joakim H., Pelaseyed, Thaher, Bas-Forsberg, Anna
Published in Frontiers in immunology (19.01.2016)
Published in Frontiers in immunology (19.01.2016)
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Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16
Bergström, Joakim H., Birchenough, George M. H., Katona, Gergely, Schroeder, Bjoern O., Schütte, André, Ermund, Anna, Johansson, Malin E. V., Hansson, Gunnar C.
Published in Proceedings of the National Academy of Sciences - PNAS (29.11.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (29.11.2016)
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Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson's disease brain
Rostami, Jinar, Fotaki, Grammatiki, Sirois, Julien, Mzezewa, Ropafadzo, Bergström, Joakim, Essand, Magnus, Healy, Luke, Erlandsson, Anna
Published in Journal of neuroinflammation (16.04.2020)
Published in Journal of neuroinflammation (16.04.2020)
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Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes
Rostami, Jinar, Holmqvist, Staffan, Lindström, Veronica, Sigvardson, Jessica, Westermark, Gunilla T, Ingelsson, Martin, Bergström, Joakim, Roybon, Laurent, Erlandsson, Anna
Published in The Journal of neuroscience (06.12.2017)
Published in The Journal of neuroscience (06.12.2017)
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Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates
Rostami, Jinar, Mothes, Tobias, Kolahdouzan, Mahshad, Eriksson, Olle, Moslem, Mohsen, Bergström, Joakim, Ingelsson, Martin, O'Callaghan, Paul, Healy, Luke M, Falk, Anna, Erlandsson, Anna
Published in Journal of neuroinflammation (03.06.2021)
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Composition and functional role of the mucus layers in the intestine
Johansson, Malin E. V., Ambort, Daniel, Pelaseyed, Thaher, Schütte, André, Gustafsson, Jenny K., Ermund, Anna, Subramani, Durai B., Holmén-Larsson, Jessica M., Thomsson, Kristina A., Bergström, Joakim H., van der Post, Sjoerd, Rodriguez-Piñeiro, Ana M., Sjövall, Henrik, Bäckström, Malin, Hansson, Gunnar C.
Published in Cellular and molecular life sciences : CMLS (01.11.2011)
Published in Cellular and molecular life sciences : CMLS (01.11.2011)
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Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage
Lindström, Veronica, Gustafsson, Gabriel, Sanders, Laurie H., Howlett, Evan H., Sigvardson, Jessica, Kasrayan, Alex, Ingelsson, Martin, Bergström, Joakim, Erlandsson, Anna
Published in Molecular and cellular neuroscience (01.07.2017)
Published in Molecular and cellular neuroscience (01.07.2017)
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AGR2, an endoplasmic reticulum protein, is secreted into the gastrointestinal mucus
Bergström, Joakim H, Berg, Katarina A, Rodríguez-Piñeiro, Ana M, Stecher, Bärbel, Johansson, Malin E V, Hansson, Gunnar C
Published in PloS one (11.08.2014)
Published in PloS one (11.08.2014)
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Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins
Rodríguez-Piñeiro, Ana M, Bergström, Joakim H, Ermund, Anna, Gustafsson, Jenny K, Schütte, André, Johansson, Malin E V, Hansson, Gunnar C
Published in American journal of physiology: Gastrointestinal and liver physiology (01.09.2013)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.09.2013)
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Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice
Lindström, Veronica, Fagerqvist, Therese, Nordström, Eva, Eriksson, Fredrik, Lord, Anna, Tucker, Stina, Andersson, Jessica, Johannesson, Malin, Schell, Heinrich, Kahle, Philipp J, Möller, Christer, Gellerfors, Pär, Bergström, Joakim, Lannfelt, Lars, Ingelsson, Martin
Published in Neurobiology of disease (01.09.2014)
Published in Neurobiology of disease (01.09.2014)
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In vivo imaging of alpha-synuclein with antibody-based PET
Roshanbin, Sahar, Xiong, Mengfei, Hultqvist, Greta, Söderberg, Linda, Zachrisson, Olof, Meier, Silvio, Ekmark-Lewén, Sara, Bergström, Joakim, Ingelsson, Martin, Sehlin, Dag, Syvänen, Stina
Published in Neuropharmacology (01.05.2022)
Published in Neuropharmacology (01.05.2022)
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Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
Gustafsson, Gabriel, Lindström, Veronica, Rostami, Jinar, Nordström, Eva, Lannfelt, Lars, Bergström, Joakim, Ingelsson, Martin, Erlandsson, Anna
Published in Journal of neuroinflammation (11.12.2017)
Published in Journal of neuroinflammation (11.12.2017)
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Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes
Domert, Jakob, Sackmann, Christopher, Severinsson, Emelie, Agholme, Lotta, Bergström, Joakim, Ingelsson, Martin, Hallbeck, Martin
Published in PloS one (28.12.2016)
Published in PloS one (28.12.2016)
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Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice
Roshanbin, Sahar, Aniszewska, Agata, Gumucio, Astrid, Masliah, Eliezer, Erlandsson, Anna, Bergström, Joakim, Ingelsson, Martin, Ekmark-Lewén, Sara
Published in Neurobiology of aging (01.05.2021)
Published in Neurobiology of aging (01.05.2021)
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