Prostate cancer reactivates developmental epigenomic programs during metastatic progression
Pomerantz, Mark M., Qiu, Xintao, Zhu, Yanyun, Takeda, David Y., Pan, Wenting, Baca, Sylvan C., Gusev, Alexander, Korthauer, Keegan D., Severson, Tesa M., Ha, Gavin, Viswanathan, Srinivas R., Seo, Ji-Heui, Nguyen, Holly M., Zhang, Baohui, Pasaniuc, Bogdan, Giambartolomei, Claudia, Alaiwi, Sarah A., Bell, Connor A., O’Connor, Edward P., Chabot, Matthew S., Stillman, David R., Lis, Rosina, Font-Tello, Alba, Li, Lewyn, Cejas, Paloma, Bergman, Andries M., Sanders, Joyce, van der Poel, Henk G., Gayther, Simon A., Lawrenson, Kate, Fonseca, Marcos A. S., Reddy, Jessica, Corona, Rosario I., Martovetsky, Gleb, Egan, Brian, Choueiri, Toni, Ellis, Leigh, Garraway, Isla P., Lee, Gwo-Shu Mary, Corey, Eva, Long, Henry W., Zwart, Wilbert, Freedman, Matthew L.
Published in Nature genetics (01.08.2020)
Published in Nature genetics (01.08.2020)
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Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial
Kwon, Eugene D, Prof, Drake, Charles G, MD, Scher, Howard I, Prof, Fizazi, Karim, Prof, Bossi, Alberto, MD, van den Eertwegh, Alfons J M, MD, Krainer, Michael, MD, Houede, Nadine, MD, Santos, Ricardo, MD, Mahammedi, Hakim, MD, Ng, Siobhan, MD, Maio, Michele, MD, Franke, Fabio A, MD, Sundar, Santhanam, MBBS, Agarwal, Neeraj, MD, Bergman, Andries M, MD, Ciuleanu, Tudor E, Prof, Korbenfeld, Ernesto, MD, Sengeløv, Lisa, MD, Hansen, Steinbjorn, MD, Logothetis, Christopher, Prof, Beer, Tomasz M, Prof, McHenry, M Brent, PhD, Gagnier, Paul, MD, Liu, David, MD, Gerritsen, Winald R, Prof
Published in The lancet oncology (01.06.2014)
Published in The lancet oncology (01.06.2014)
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Androgen receptor enhancer usage and the chromatin regulatory landscape in human prostate cancers
Stelloo, Suzan, Bergman, Andries M, Zwart, Wilbert
Published in Endocrine-related cancer (01.05.2019)
Published in Endocrine-related cancer (01.05.2019)
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The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact
van Dessel, Lisanne F., van Riet, Job, Smits, Minke, Zhu, Yanyun, Hamberg, Paul, van der Heijden, Michiel S., Bergman, Andries M., van Oort, Inge M., de Wit, Ronald, Voest, Emile E., Steeghs, Neeltje, Yamaguchi, Takafumi N., Livingstone, Julie, Boutros, Paul C., Martens, John W. M., Sleijfer, Stefan, Cuppen, Edwin, Zwart, Wilbert, van de Werken, Harmen J. G., Mehra, Niven, Lolkema, Martijn P.
Published in Nature communications (20.11.2019)
Published in Nature communications (20.11.2019)
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Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion
Cioni, Bianca, Zaalberg, Anniek, van Beijnum, Judy R., Melis, Monique H. M., van Burgsteden, Johan, Muraro, Mauro J., Hooijberg, Erik, Peters, Dennis, Hofland, Ingrid, Lubeck, Yoni, de Jong, Jeroen, Sanders, Joyce, Vivié, Judith, van der Poel, Henk G., de Boer, Jan Paul, Griffioen, Arjan W., Zwart, Wilbert, Bergman, Andries M.
Published in Nature communications (09.09.2020)
Published in Nature communications (09.09.2020)
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CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis
Augello, Michael A., Liu, Deli, Deonarine, Lesa D., Robinson, Brian D., Huang, Dennis, Stelloo, Suzan, Blattner, Mirjam, Doane, Ashley S., Wong, Elissa W.P., Chen, Yu, Rubin, Mark A., Beltran, Himisha, Elemento, Olivier, Bergman, Andries M., Zwart, Wilbert, Sboner, Andrea, Dephoure, Noah, Barbieri, Christopher E.
Published in Cancer cell (15.04.2019)
Published in Cancer cell (15.04.2019)
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Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors
Mazrooei, Parisa, Kron, Ken J., Zhu, Yanyun, Zhou, Stanley, Grillo, Giacomo, Mehdi, Tahmid, Ahmed, Musaddeque, Severson, Tesa M., Guilhamon, Paul, Armstrong, Nicholas Sinnott, Huang, Vincent, Yamaguchi, Takafumi N., Fraser, Michael, van der Kwast, Theodorus, Boutros, Paul C., He, Housheng Hansen, Bergman, Andries M., Bristow, Robert G., Zwart, Wilbert, Lupien, Mathieu
Published in Cancer cell (09.12.2019)
Published in Cancer cell (09.12.2019)
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Custirsen in combination with docetaxel and prednisone for patients with metastatic castration-resistant prostate cancer (SYNERGY trial): a phase 3, multicentre, open-label, randomised trial
Chi, Kim N, Prof, Higano, Celestia S, MD, Blumenstein, Brent, PhD, Ferrero, Jean-Marc, Prof, Reeves, James, MD, Feyerabend, Susan, MD, Gravis, Gwenaelle, MD, Merseburger, Axel S, Prof, Stenzl, Arnulf, Prof, Bergman, Andries M, MD, Mukherjee, Som D, MD, Zalewski, Pawel, MD, Saad, Fred, Prof, Jacobs, Cindy, MD, Gleave, Martin, Prof, de Bono, Johann S, Prof
Published in The lancet oncology (01.04.2017)
Published in The lancet oncology (01.04.2017)
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A kinome-centered CRISPR-Cas9 screen identifies activated BRAF to modulate enzalutamide resistance with potential therapeutic implications in BRAF-mutated prostate cancer
Palit, Sander A. L., van Dorp, Jeroen, Vis, Daniel, Lieftink, Cor, Linder, Simon, Beijersbergen, Roderick, Bergman, Andries M., Zwart, Wilbert, van der Heijden, Michiel S.
Published in Scientific reports (01.07.2021)
Published in Scientific reports (01.07.2021)
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Loss of androgen receptor signaling in prostate cancer‐associated fibroblasts (CAFs) promotes CCL2‐ and CXCL8‐mediated cancer cell migration
Cioni, Bianca, Nevedomskaya, Ekaterina, Melis, Monique H. M., Burgsteden, Johan, Stelloo, Suzan, Hodel, Emma, Spinozzi, Daniele, Jong, Jeroen, der Poel, Henk, Boer, Jan Paul, Wessels, Lodewyk F. A., Zwart, Wilbert, Bergman, Andries M.
Published in Molecular oncology (01.08.2018)
Published in Molecular oncology (01.08.2018)
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Functional mapping of androgen receptor enhancer activity
Huang, Chia-Chi Flora, Lingadahalli, Shreyas, Morova, Tunc, Ozturan, Dogancan, Hu, Eugene, Yu, Ivan Pak Lok, Linder, Simon, Hoogstraat, Marlous, Stelloo, Suzan, Sar, Funda, van der Poel, Henk, Altintas, Umut Berkay, Saffarzadeh, Mohammadali, Le Bihan, Stephane, McConeghy, Brian, Gokbayrak, Bengul, Feng, Felix Y, Gleave, Martin E, Bergman, Andries M, Collins, Colin, Hach, Faraz, Zwart, Wilbert, Emberly, Eldon, Lack, Nathan A
Published in Genome Biology (11.05.2021)
Published in Genome Biology (11.05.2021)
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Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer
Che, Meixia, Chaturvedi, Aashi, Munro, Sarah A., Pitzen, Samuel P., Ling, Alex, Zhang, Weijie, Mentzer, Josh, Ku, Sheng-Yu, Puca, Loredana, Zhu, Yanyun, Bergman, Andries M., Severson, Tesa M., Forster, Colleen, Liu, Yuzhen, Hildebrand, Jacob, Daniel, Mark, Wang, Ting-You, Selth, Luke A., Hickey, Theresa, Zoubeidi, Amina, Gleave, Martin, Bareja, Rohan, Sboner, Andrea, Tilley, Wayne, Carroll, Jason S., Tan, Winston, Kohli, Manish, Yang, Rendong, Hsieh, Andrew C., Murugan, Paari, Zwart, Wilbert, Beltran, Himisha, Huang, R. Stephanie, Dehm, Scott M.
Published in Nature communications (04.11.2021)
Published in Nature communications (04.11.2021)
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Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential
Kneppers, Jeroen, Severson, Tesa M., Siefert, Joseph C., Schol, Pieter, Joosten, Stacey E. P., Yu, Ivan Pak Lok, Huang, Chia-Chi Flora, Morova, Tunç, Altıntaş, Umut Berkay, Giambartolomei, Claudia, Seo, Ji-Heui, Baca, Sylvan C., Carneiro, Isa, Emberly, Eldon, Pasaniuc, Bogdan, Jerónimo, Carmen, Henrique, Rui, Freedman, Matthew L., Wessels, Lodewyk F. A., Lack, Nathan A., Bergman, Andries M., Zwart, Wilbert
Published in Nature communications (30.11.2022)
Published in Nature communications (30.11.2022)
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Androgen receptor profiling predicts prostate cancer outcome
Stelloo, Suzan, Nevedomskaya, Ekaterina, van der Poel, Henk G, de Jong, Jeroen, van Leenders, Geert JLH, Jenster, Guido, Wessels, Lodewyk FA, Bergman, Andries M, Zwart, Wilbert
Published in EMBO molecular medicine (01.11.2015)
Published in EMBO molecular medicine (01.11.2015)
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A common germline variant in CYP11B1 is associated with adverse clinical outcome of treatment with abiraterone or enzalutamide
Buck, Stefan A.J., Meertens, Marinda, van Ooijen, Frederiek M.F., Oomen-de Hoop, Esther, de Jonge, Evert, Coenen, Marieke J.H., Bergman, Andries M., Koolen, Stijn L.W., de Wit, Ronald, Huitema, Alwin D.R., van Schaik, Ron H.N., Mathijssen, Ron H.J.
Published in Biomedicine & pharmacotherapy (31.12.2023)
Published in Biomedicine & pharmacotherapy (31.12.2023)
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TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth
Palit, Sander Al, Vis, Daniel, Stelloo, Suzan, Lieftink, Cor, Prekovic, Stefan, Bekers, Elise, Hofland, Ingrid, Šuštić, Tonći, Wolters, Liesanne, Beijersbergen, Roderick, Bergman, Andries M, Győrffy, Balázs, Wessels, Lodewyk Fa, Zwart, Wilbert, van der Heijden, Michiel S
Published in eLife (19.12.2019)
Published in eLife (19.12.2019)
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Real-world outcomes of radium-223 dichloride for metastatic castration resistant prostate cancer
Kuppen, Malou Cp, Westgeest, Hans M, van der Doelen, Maarten J, van den Eertwegh, Alphonsus Jm, Coenen, Jules Llm, Aben, Katja Kh, van den Bergh, Alphons Cm, Bergman, Andries M, den Bosch, Joan van, Celik, Filiz, Hendriks, Mathijs P, Lavalaye, Jules, der Meer, Saskia van, Polee, Marco B, Somford, Diederik M, van Oort, Inge M, Uyl-de Groot, Carin A, Gerritsen, Winald R
Published in Future oncology (London, England) (01.07.2020)
Published in Future oncology (London, England) (01.07.2020)
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Epigenetic and transcriptional analysis reveals a core transcriptional program conserved in clonal prostate cancer metastases
Severson, Tesa M., Zhu, Yanyun, De Marzo, Angelo M., Jones, Tracy, Simons, Jonathan W., Nelson, William G., Yegnasubramanian, Srinivasan, Freedman, Matthew L., Wessels, Lodewyk, Bergman, Andries M., Haffner, Michael C., Zwart, Wilbert
Published in Molecular oncology (01.07.2021)
Published in Molecular oncology (01.07.2021)
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Agent-based modeling of the prostate tumor microenvironment uncovers spatial tumor growth constraints and immunomodulatory properties
van Genderen, Maisa N. G., Kneppers, Jeroen, Zaalberg, Anniek, Bekers, Elise M., Bergman, Andries M., Zwart, Wilbert, Eduati, Federica
Published in NPJ systems biology and applications (21.02.2024)
Published in NPJ systems biology and applications (21.02.2024)
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Carboplatin Based Induction Chemotherapy for Nonorgan Confined Bladder Cancer—A Reasonable Alternative for Cisplatin Unfit Patients?
Mertens, Laura S, Meijer, Richard P, Kerst, J. Martijn, Bergman, Andries M, van Tinteren, Harm, van Rhijn, Bas W.G, Horenblas, Simon
Published in The Journal of urology (01.10.2012)
Published in The Journal of urology (01.10.2012)
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