Synthesis and Activity of Analogues of SB-219383: Novel Potent Inhibitors of Bacterial Tyrosyl tRNA Synthetase
BERGE, JOHN M., BROOM, NIGEL J. P., HOUGE-FRYDRYCH, CATHERINE S. V., JARVEST, RICHARD L., MENSAH, LUCY, MCNAIR, DAVID J., O'HANLON, PETER J., POPE, ANDREW J., RITTENHOUSE, STEPHEN
Published in Journal of antibiotics (01.11.2000)
Published in Journal of antibiotics (01.11.2000)
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Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens
JARVEST, Richard L., BERGE, John M., BERRY, Valerie, BOYD, Helen F., BROWN, Murray J., ELDER, John S., FORREST, Andrew K., FOSBERRY, Andrew P., GENTRY, Daniel R., HIBBS, Martin J., JAWORSKI, Deborah D., O'HANLON, Peter J., POPE, Andrew J., RITTENHOUSE, Stephen, SHEPPARD, Robert J., SLATER-RADOSTI, Courtney, WORBY, Angela
Published in Journal of medicinal chemistry (09.05.2002)
Published in Journal of medicinal chemistry (09.05.2002)
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Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues
Jarvest, Richard L, Armstrong, Sula A, Berge, John M, Brown, Pamela, Elder, John S, Brown, Murray J, Copley, Royston C.B, Forrest, Andrew K, Hamprecht, Dieter W, O'Hanlon, Peter J, Mitchell, Darren J, Rittenhouse, Stephen, Witty, David R
Published in Bioorganic & medicinal chemistry letters (02.08.2004)
Published in Bioorganic & medicinal chemistry letters (02.08.2004)
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Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-Positive antibacterial activity
Jarvest, Richard L, Berge, John M, Brown, Murray J, Brown, Pamela, Elder, John S, Forrest, Andrew K, Houge-Frydrych, C.S.V, O'Hanlon, Peter J, McNair, David J, Rittenhouse, Stephen, Sheppard, Robert J
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
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Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-Positive antibacterial activity
Jarvest, Richard L., Berge, John M., Brown, Pamela, Houge-Frydrych, Catherine S.V., O'Hanlon, Peter J., McNair, David J., Pope, Andrew J., Rittenhouse, Stephen
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
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Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383
Jarvest, Richard L, Berge, John M, Brown, Pamela, Hamprecht, Dieter W, McNair, David J, Mensah, Lucy, O'Hanlon, Peter J, Pope, Andrew J
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
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Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383
Berge, John M, Copley, Royston C.B, Eggleston, Drake S, Hamprecht, Dieter W, Jarvest, Richard L, Mensah, Lucy M, O'Hanlon, Peter J, Pope, Andrew J
Published in Bioorganic & medicinal chemistry letters (21.08.2000)
Published in Bioorganic & medicinal chemistry letters (21.08.2000)
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Inhibitors of Bacterial Tyrosyl tRNA Synthetase: Synthesis of Carbocyclic Analogues of the Natural Product SB-219383
Jarvest, Richard L, Berge, John M, Houge-Frydrych, Catherine S.V, Mensah, Lucy M, O'Hanlon, Peter J, Pope, Andrew J
Published in Bioorganic & medicinal chemistry letters (17.09.2001)
Published in Bioorganic & medicinal chemistry letters (17.09.2001)
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Nanomolar Inhibitors of Staphylococcus a ureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens
Jarvest, Richard L, Berge, John M, Berry, Valerie, Boyd, Helen F, Brown, Murray J, Elder, John S, Forrest, Andrew K, Fosberry, Andrew P, Gentry, Daniel R, Hibbs, Martin J, Jaworski, Deborah D, O'Hanlon, Peter J, Pope, Andrew J, Rittenhouse, Stephen, Sheppard, Robert J, Slater-Radosti, Courtney, Worby, Angela
Published in Journal of medicinal chemistry (09.05.2002)
Published in Journal of medicinal chemistry (09.05.2002)
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Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: Inhibition and crystal structure of a complex
Jarvest, Richard L., Berge, John M., Houge-Frydrych, Catherine S.V., Janson, Cheryl, Mensah, Lucy M., O'Hanlon, Peter J., Pope, Andrew, Saldanha, Adrian, Xiayang Qiu
Published in Bioorganic & medicinal chemistry letters (04.10.1999)
Published in Bioorganic & medicinal chemistry letters (04.10.1999)
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The Contribution of Classical (β1/2-) and Atypical β-Adrenoceptors to the Stimulation of Human White Adipocyte Lipolysis and Right Atrial Appendage Contraction by Novel β3-Adrenoceptor Agonists of Differing Selectivities
Matthew V. Sennitt, Alberto J. Kaumann, Peter Molenaar, Lee J. Beeley, Paul W. Young, John Kelly, Helen Chapman, Sian M. Henson, John M. Berge, David K. Dean, Nikesh R. Kotecha, Helen K. A. Morgan, Harshad K. Rami, Robert W. Ward, Mervyn Thompson, Shelagh Wilson, Stephen A. Smith, Michael A. Cawthorne, Michael J. Stock, Jonathan R. S. Arch
Published in The Journal of pharmacology and experimental therapeutics (01.06.1998)
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Published in The Journal of pharmacology and experimental therapeutics (01.06.1998)
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Synthesis of a selective alpha-2A adrenoceptor antagonist, BRL 48962, and its characterization at cloned human alpha-adrenoceptors
Beeley, Lee J., Berge, John M., Chapman, Helen, Hieble, Paul, Kelly, John, Naselsky, Diane P., Rockell, Caroline M., Young, Paul W.
Published in Bioorganic & medicinal chemistry (01.12.1995)
Published in Bioorganic & medicinal chemistry (01.12.1995)
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