Discovery of a Photoaffinity Probe that Captures the Active Conformation of the Cannabinoid CB2 Receptor
De Paus, Laura V., An, Yu, Janssen, Antonius P. A., Berg, Richard J. B. H. N., Heitman, Laura H., Stelt, Mario
Published in Chembiochem : a European journal of chemical biology (02.04.2024)
Published in Chembiochem : a European journal of chemical biology (02.04.2024)
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Journal Article
Structural basis of selective cannabinoid CB2 receptor activation
Li, Xiaoting, Chang, Hao, Bouma, Jara, de Paus, Laura V., Mukhopadhyay, Partha, Paloczi, Janos, Mustafa, Mohammed, van der Horst, Cas, Kumar, Sanjay Sunil, Wu, Lijie, Yu, Yanan, van den Berg, Richard J. B. H. N., Janssen, Antonius P. A., Lichtman, Aron, Liu, Zhi-Jie, Pacher, Pal, van der Stelt, Mario, Heitman, Laura H., Hua, Tian
Published in Nature communications (15.03.2023)
Published in Nature communications (15.03.2023)
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Journal Article
Glycosphingolipids-Nature, Function, and Pharmacological Modulation
Wennekes, Tom, van den Berg, Richard J. B. H. N., Boot, Rolf G., van der Marel, Gijsbert A., Overkleeft, Herman S., Aerts, Johannes M. F. G.
Published in Angewandte Chemie (International ed.) (09.11.2009)
Published in Angewandte Chemie (International ed.) (09.11.2009)
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Journal Article
Development of Adamantan-1-yl-methoxy-Functionalized 1-Deoxynojirimycin Derivatives as Selective Inhibitors of Glucosylceramide Metabolism in Man
Wennekes, Tom, van den Berg, Richard J. B. H. N, Donker, Wilma, van der Marel, Gijsbert A, Strijland, Anneke, Aerts, Johannes M. F. G, Overkleeft, Herman S
Published in Journal of organic chemistry (16.02.2007)
Published in Journal of organic chemistry (16.02.2007)
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Journal Article
The Development of an Aza-C-Glycoside Library Based on a Tandem Staudinger/Aza-Wittig/Ugi Three-Component Reaction
Wennekes, Tom, Bonger, Kimberly M., Vogel, Katrin, van den Berg, Richard J. B. H. N., Strijland, Anneke, Donker-Koopman, Wilma E., Aerts, Johannes M. F. G., van der Marel, Gijsbert A., Overkleeft, Herman S.
Published in European journal of organic chemistry (01.11.2012)
Published in European journal of organic chemistry (01.11.2012)
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Journal Article
Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria
Bakker, Alexander T., Kotsogianni, Ioli, Avalos, Mariana, Punt, Jeroen M., Liu, Bing, Piermarini, Diana, Gagestein, Berend, Slingerland, Cornelis J., Zhang, Le, Willemse, Joost J., Ghimire, Leela B., van den Berg, Richard J. H. B. N., Janssen, Antonius P. A., Ottenhoff, Tom H. M., van Boeckel, Constant A. A., van Wezel, Gilles P., Ghilarov, Dmitry, Martin, Nathaniel I., van der Stelt, Mario
Published in Nature chemistry (01.09.2024)
Published in Nature chemistry (01.09.2024)
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Journal Article
Synthesis of l-altro-1-Deoxynojirimycin, d-allo-1-Deoxynojirimycin, and d-galacto-1-Deoxynojirimycin from a Single Chiral Cyanohydrin
van den Nieuwendijk, Adrianus M. C. H, Ruben, Mark, Engelsma, Sander E, Risseeuw, Martijn D. P, van den Berg, Richard J. B. H. N, Boot, Rolf G, Aerts, Johannes M, Brussee, Johannes, van der Marel, Gijs A, Overkleeft, Herman S
Published in Organic letters (03.09.2010)
Published in Organic letters (03.09.2010)
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Journal Article
Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding
Deng, Hui, Kooijman, Sander, van den Nieuwendijk, Adrianus M. C. H, Ogasawara, Daisuke, van der Wel, Tom, van Dalen, Floris, Baggelaar, Marc P, Janssen, Freek J, van den Berg, Richard J. B. H. N, den Dulk, Hans, Cravatt, Benjamin F, Overkleeft, Herman S, Rensen, Patrick C. N, van der Stelt, Mario
Published in Journal of medicinal chemistry (12.01.2017)
Published in Journal of medicinal chemistry (12.01.2017)
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Journal Article
An Efficient Synthesis of the Natural Tetrahydrofuran Pachastrissamine Starting from d-ribo-Phytosphingosine
van den Berg, Richard J. B. H. N, Boltje, Thomas J, Verhagen, Carlo P, Litjens, Remy E. J. N, van der Marel, Gijsbert A, Overkleeft, Herman S
Published in Journal of organic chemistry (20.01.2006)
Published in Journal of organic chemistry (20.01.2006)
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Journal Article
Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors
van den Berg, Richard J. B. H. N., van Rijssel, Erwin R., Ferraz, Maria Joao, Houben, Judith, Strijland, Anneke, Donker-Koopman, Wilma E., Wennekes, Tom, Bonger, Kimberly M., Ghisaidoobe, Amar B. T., Hoogendoorn, Sascha, van der Marel, Gijsbert A., Codée, Jeroen D. C., Overkleeft, Herman S., Aerts, Johannes M. F. G.
Published in ChemMedChem (01.12.2015)
Published in ChemMedChem (01.12.2015)
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Journal Article
Identification and Development of Biphenyl Substituted Iminosugars as Improved Dual Glucosylceramide Synthase/Neutral Glucosylceramidase Inhibitors
Ghisaidoobe, Amar T, van den Berg, Richard J. B. H. N, Butt, Saleem S, Strijland, Anneke, Donker-Koopman, Wilma E, Scheij, Saskia, van den Nieuwendijk, Adrianus M. C. H, Koomen, Gerrit-Jan, van Loevezijn, Arnold, Leemhuis, Mark, Wennekes, Tom, van der Stelt, Mario, van der Marel, Gijsbert A, van Boeckel, Constant A. A, Aerts, Johannes M. F. G, Overkleeft, Herman S
Published in Journal of medicinal chemistry (13.11.2014)
Published in Journal of medicinal chemistry (13.11.2014)
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Journal Article
Synthesis of 6‑Hydroxysphingosine and α‑Hydroxy Ceramide Using a Cross-Metathesis Strategy
Wisse, Patrick, de Geus, Mark A. R, Cross, Gen, van den Nieuwendijk, Adrianus M. C. H, van Rooden, Eva J, van den Berg, Richard J. B. H. N, Aerts, Johannes M. F. G, van der Marel, Gijsbert A, Codée, Jeroen D. C, Overkleeft, Herman S
Published in Journal of organic chemistry (17.07.2015)
Published in Journal of organic chemistry (17.07.2015)
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Journal Article
Two-step activity-based protein profiling of diacylglycerol lipase
van Rooden, Eva J., Kreekel, Roy, Hansen, Thomas, Janssen, Antonius P. A., van Esbroeck, Annelot C. M., den Dulk, Hans, van den Berg, Richard J. B. H. N., Codee, Jeroen D. C., van der Stelt, Mario
Published in Organic & biomolecular chemistry (2018)
Published in Organic & biomolecular chemistry (2018)
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Journal Article
A chemical genetic screen reveals that iminosugar inhibitors of plant glucosylceramide synthase inhibit root growth in Arabidopsis and cereals
Rugen, Michael D, Vernet, Mathieu M J L, Hantouti, Laila, Soenens, Amalia, Andriotis, Vasilios M E, Rejzek, Martin, Brett, Paul, van den Berg, Richard J B H N, Aerts, Johannes M F G, Overkleeft, Hermen S, Field, Robert A
Published in Scientific reports (06.11.2018)
Published in Scientific reports (06.11.2018)
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Journal Article
Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α‑Glucosidase II Inhibitor, Blocks Replication of SARS-CoV‑2 and Other Coronaviruses
Thaler, Melissa, Ofman, Tim P., Kok, Ken, Heming, Jurriaan J. A., Moran, Elisha, Pickles, Isabelle, Leijs, Anouk A., van den Nieuwendijk, Adrianus M. C. H., van den Berg, Richard J. B. H. N., Ruijgrok, Gijs, Armstrong, Zachary, Salgado-Benvindo, Clarisse, Ninaber, Dennis K., Snijder, Eric J., van Boeckel, Constant A. A., Artola, Marta, Davies, Gideon J., Overkleeft, Herman S., van Hemert, Martijn J.
Published in ACS central science (28.08.2024)
Published in ACS central science (28.08.2024)
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Journal Article
Synthesis and evaluation of homo-bivalent GnRHR ligands
Bonger, Kimberly M., van den Berg, Richard J.B.H.N., Heitman, Laura H., IJzerman, Ad P., Oosterom, Julia, Timmers, Cornelis M., Overkleeft, Herman S., van der Marel, Gijsbert A.
Published in Bioorganic & medicinal chemistry (15.07.2007)
Published in Bioorganic & medicinal chemistry (15.07.2007)
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Journal Article
ortho-Carborane-Modified N-Substituted Deoxynojirimycins
Hoogendoorn, Sascha, Mock, Elliot D., Strijland, Anneke, Donker-Koopman, Wilma E., van den Elst, Hans, van den Berg, Richard J. B. H. N., Aerts, Johannes M. F. G., van der Marel, Gijsbert A., Overkleeft, Herman S.
Published in European journal of organic chemistry (01.07.2015)
Published in European journal of organic chemistry (01.07.2015)
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Journal Article
Synthesis and Evaluation of Lipophilic Aza-C-glycosides as Inhibitors of Glucosylceramide Metabolism
Wennekes, Tom, van den Berg, Richard J. B. H. N., Boltje, Thomas J., Donker-Koopman, Wilma E., Kuijper, Bastiaan, van der Marel, Gijsbert A., Strijland, Anneke, Verhagen, Carlo P., Aerts, Johannes M. F. G., Overkleeft, Herman S.
Published in European Journal of Organic Chemistry (01.03.2010)
Published in European Journal of Organic Chemistry (01.03.2010)
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Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase
Scherpenzeel, Monique van, van den Berg, Richard J.B.H.N., Donker-Koopman, Wilma E., Liskamp, Rob M.J., Aerts, Johannes M.F.G., Overkleeft, Herman S., Pieters, Roland J.
Published in Bioorganic & medicinal chemistry (2010)
Published in Bioorganic & medicinal chemistry (2010)
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