Lead Optimization of a 4‑Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors
Liang, Jun, van Abbema, Anne, Balazs, Mercedesz, Barrett, Kathy, Berezhkovsky, Leo, Blair, Wade, Chang, Christine, Delarosa, Donnie, DeVoss, Jason, Driscoll, Jim, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Halladay, Jason, Johnson, Adam, Kohli, Pawan Bir, Lai, Yingjie, Liu, Yanzhou, Lyssikatos, Joseph, Mantik, Priscilla, Menghrajani, Kapil, Murray, Jeremy, Peng, Ivan, Sambrone, Amy, Shia, Steven, Shin, Young, Smith, Jan, Sohn, Sue, Tsui, Vickie, Ultsch, Mark, Wu, Lawren C, Xiao, Yisong, Yang, Wenqian, Young, Judy, Zhang, Birong, Zhu, Bing-yan, Magnuson, Steven
Published in Journal of medicinal chemistry (13.06.2013)
Published in Journal of medicinal chemistry (13.06.2013)
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Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model
Liang, Jun, Van Abbema, Anne, Balazs, Mercedesz, Barrett, Kathy, Berezhkovsky, Leo, Blair, Wade S., Chang, Christine, Delarosa, Donnie, DeVoss, Jason, Driscoll, Jim, Eigenbrot, Charles, Goodacre, Simon, Ghilardi, Nico, MacLeod, Calum, Johnson, Adam, Bir Kohli, Pawan, Lai, Yingjie, Lin, Zhonghua, Mantik, Priscilla, Menghrajani, Kapil, Nguyen, Hieu, Peng, Ivan, Sambrone, Amy, Shia, Steven, Smith, Jan, Sohn, Sue, Tsui, Vickie, Ultsch, Mark, Williams, Karen, Wu, Lawren C., Yang, Wenqian, Zhang, Birong, Magnuson, Steven
Published in Bioorganic & medicinal chemistry letters (15.09.2017)
Published in Bioorganic & medicinal chemistry letters (15.09.2017)
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