Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit
Willis, Nicky J., Mahy, William, Sipthorp, James, Zhao, Yuguang, Woodward, Hannah L., Atkinson, Benjamin N., Bayle, Elliott D., Svensson, Fredrik, Frew, Sarah, Jeganathan, Fiona, Monaghan, Amy, Benvegnù, Stefano, Jolly, Sarah, Vecchia, Luca, Ruza, Reinis R., Kjær, Svend, Howell, Steven, Snijders, Ambrosius P., Bictash, Magda, Salinas, Patricia C., Vincent, Jean-Paul, Jones, E. Yvonne, Whiting, Paul, Fish, Paul V.
Published in Journal of medicinal chemistry (26.05.2022)
Published in Journal of medicinal chemistry (26.05.2022)
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Journal Article
Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters
Palomer, Ernest, Martín-Flores, Núria, Jolly, Sarah, Pascual-Vargas, Patricia, Benvegnù, Stefano, Podpolny, Marina, Teo, Samuel, Vaher, Kadi, Saito, Takashi, Saido, Takaomi C., Whiting, Paul, Salinas, Patricia C.
Published in Molecular psychiatry (01.07.2022)
Published in Molecular psychiatry (01.07.2022)
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Correction: Prion Protein Paralog Doppel Protein Interacts with Alpha-2-Macroglobulin: A Plausible Mechanism for Doppel-Mediated Neurodegeneration
Benvegnù, Stefano, Franciotta, Diego, Sussman, Josh, Bachi, Angela, Zardini, Elisabetta, Torreri, Paola, Govaerts, Cedric, Pizzo, Salvatore, Legname, Giuseppe
Published in PloS one (18.08.2009)
Published in PloS one (18.08.2009)
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Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival
Benvegnù, Stefano, Mateo, María Inés, Palomer, Ernest, Jurado-Arjona, Jerónimo, Dotti, Carlos G.
Published in Molecular cell (04.05.2017)
Published in Molecular cell (04.05.2017)
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Glycogen synthase kinase-3β regulates fractalkine production by altering its trafficking from Golgi to plasma membrane: implications for Alzheimer’s disease
Fuster-Matanzo, Almudena, Jurado-Arjona, Jerónimo, Benvegnù, Stefano, García, Esther, Martín-Maestro, Patricia, Gómez-Sintes, Raquel, Hernández, Félix, Ávila, Jesús
Published in Cellular and molecular life sciences : CMLS (01.03.2017)
Published in Cellular and molecular life sciences : CMLS (01.03.2017)
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Developmental influence of the cellular prion protein on the gene expression profile in mouse hippocampus
Benvegnù, Stefano, Roncaglia, Paola, Agostini, Federica, Casalone, Cristina, Corona, Cristiano, Gustincich, Stefano, Legname, Giuseppe
Published in Physiological genomics (01.06.2011)
Published in Physiological genomics (01.06.2011)
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Aged PrP null mice show defective processing of neuregulins in the peripheral nervous system
Benvegnù, Stefano, Gasperini, Lisa, Legname, Giuseppe
Published in Molecular and cellular neuroscience (01.05.2011)
Published in Molecular and cellular neuroscience (01.05.2011)
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Journal Article
Prion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegeneration
Benvegnù, Stefano, Franciotta, Diego, Sussman, Josh, Bachi, Angela, Zardini, Elisabetta, Torreri, Paola, Govaerts, Cedric, Pizzo, Salvatore, Legname, Giuseppe
Published in PloS one (18.06.2009)
Published in PloS one (18.06.2009)
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Journal Article
Glycogen synthase kinase-3[beta] regulates fractalkine production by altering its trafficking from Golgi to plasma membrane: implications for Alzheimer's disease
Fuster-matanzo, Almudena, Jurado-arjona, Jerónimo, Benvegnù, Stefano, García, Esther, Martín-maestro, Patricia, Gómez-sintes, Raquel, Hernández, Félix, Ávila, Jesús
Published in Cellular and molecular life sciences : CMLS (01.03.2017)
Published in Cellular and molecular life sciences : CMLS (01.03.2017)
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Journal Article
Small-molecule inhibitors of carboxylesterase Notum
Zhao, Yuguang, Jolly, Sarah, Benvegnu, Stefano, Jones, E Yvonne, Fish, Paul V
Published in Future medicinal chemistry (01.06.2021)
Published in Future medicinal chemistry (01.06.2021)
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Journal Article
Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters
Palomer, Ernest, Martin-Flores, Núria, Jolly, Sarah, Pascual-Vargas, Patricia, Benvegnù, Stefano, Podpolny, Marina, Kadi Vaher, Saito, Takashi, Sado, Takaomi C, Whiting, Paul, Salinas, Patricia C
Published in bioRxiv (13.08.2021)
Published in bioRxiv (13.08.2021)
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