Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp
Lumen, Annie Albin, Li, Libin, Li, Jiben, Ahmed, Zeba, Meng, Zhou, Owen, Albert, Ellens, Harma, Hidalgo, Ismael J, Bentz, Joe
Published in PloS one (16.08.2013)
Published in PloS one (16.08.2013)
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Fitting the elementary rate constants of the P-gp transporter network in the hMDR1-MDCK confluent cell monolayer using a particle swarm algorithm
Agnani, Deep, Acharya, Poulomi, Martinez, Esteban, Tran, Thuy Thanh, Abraham, Feby, Tobin, Frank, Ellens, Harma, Bentz, Joe
Published in PloS one (18.10.2011)
Published in PloS one (18.10.2011)
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Kinetic Identification of Membrane Transporters That Assist P-glycoprotein-Mediated Transport of Digoxin and Loperamide through a Confluent Monolayer of MDCKII-hMDR1 Cells
Acharya, Poulomi, O'Connor, Michael P, Polli, Joseph W, Ayrton, Andrew, Ellens, Harma, Bentz, Joe
Published in Drug metabolism and disposition (01.02.2008)
Published in Drug metabolism and disposition (01.02.2008)
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Exact kinetic analysis of passive transport across a polarized confluent MDCK cell monolayer modeled as a single barrier
Tran, Thuy Thanh, Gales, Tracy, Maleeff, Beverly, Aldinger, Tanya, Polli, Joseph W., Ayrton, Andrew, Ellens, Harma, Bentz, Joe, Mittal, Aditya
Published in Journal of pharmaceutical sciences (01.08.2004)
Published in Journal of pharmaceutical sciences (01.08.2004)
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If the KI Is Defined by the Free Energy of Binding to P-Glycoprotein, Which Kinetic Parameters Define the IC50 for the Madin-Darby Canine Kidney II Cell Line Overexpressing Human Multidrug Resistance 1 Confluent Cell Monolayer?
Lumen, Annie Albin, Acharya, Poulomi, Polli, Joseph W, Ayrton, Andrew, Ellens, Harma, Bentz, Joe
Published in Drug metabolism and disposition (01.02.2010)
Published in Drug metabolism and disposition (01.02.2010)
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Variability in P-glycoprotein inhibitory potency (IC₅₀) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria
Bentz, Joe, O'Connor, Michael P, Bednarczyk, Dallas, Coleman, Joann, Lee, Caroline, Palm, Johan, Pak, Y Anne, Perloff, Elke S, Reyner, Eric, Balimane, Praveen, Brännström, Marie, Chu, Xiaoyan, Funk, Christoph, Guo, Ailan, Hanna, Imad, Herédi-Szabó, Krisztina, Hillgren, Kate, Li, Libin, Hollnack-Pusch, Evelyn, Jamei, Masoud, Lin, Xuena, Mason, Andrew K, Neuhoff, Sibylle, Patel, Aarti, Podila, Lalitha, Plise, Emile, Rajaraman, Ganesh, Salphati, Laurent, Sands, Eric, Taub, Mitchell E, Taur, Jan-Shiang, Weitz, Dietmar, Wortelboer, Heleen M, Xia, Cindy Q, Xiao, Guangqing, Yabut, Jocelyn, Yamagata, Tetsuo, Zhang, Lei, Ellens, Harma
Published in Drug metabolism and disposition (01.07.2013)
Published in Drug metabolism and disposition (01.07.2013)
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Mechanistic kinetic modeling generates system-independent P-glycoprotein mediated transport elementary rate constants for inhibition and, in combination with 3D SIM microscopy, elucidates the importance of microvilli morphology on P-glycoprotein mediated efflux activity
Ellens, Harma, Meng, Zhou, Le Marchand, Sylvain J, Bentz, Joe
Published in Expert opinion on drug metabolism & toxicology (03.06.2018)
Published in Expert opinion on drug metabolism & toxicology (03.06.2018)
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Derivation of a System-Independent K^sub i^ for P-glycoprotein Mediated Digoxin Transport from System-Dependent IC^sub 50^ Data
Chaudhry, Aqsaa, Chung, Git, Lynn, Adam, Yalvigi, Akshata, Brown, Colin, Ellens, Harma, O’Connor, Michael, Lee, Caroline, Bentz, Joe
Published in Drug metabolism and disposition (01.03.2018)
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Published in Drug metabolism and disposition (01.03.2018)
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Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactions
Ellens, Harma, Deng, Shibing, Coleman, Joann, Bentz, Joe, Taub, Mitchell E, Ragueneau-Majlessi, Isabelle, Chung, Sophie P, Herédi-Szabó, Krisztina, Neuhoff, Sibylle, Palm, Johan, Balimane, Praveen, Zhang, Lei, Jamei, Masoud, Hanna, Imad, O'Connor, Michael, Bednarczyk, Dallas, Forsgard, Malin, Chu, Xiaoyan, Funk, Christoph, Guo, Ailan, Hillgren, Kathleen M, Li, Libin, Pak, Anne Y, Perloff, Elke S, Rajaraman, Ganesh, Salphati, Laurent, Taur, Jan-Shiang, Weitz, Dietmar, Wortelboer, Heleen M, Xia, Cindy Q, Xiao, Guangqing, Yamagata, Tetsuo, Lee, Caroline A
Published in Drug metabolism and disposition (01.07.2013)
Published in Drug metabolism and disposition (01.07.2013)
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