Chimeric antigen receptors enable superior control of HIV replication by rapidly killing infected cells
Zhou, Yuqi, Jadlowsky, Julie, Baiduc, Caitlin, Klattenhoff, Alex W, Chen, Zhilin, Bennett, Alan D, Pumphrey, Nicholas J, Jakobsen, Bent K, Riley, James L
Published in PLoS pathogens (01.12.2023)
Published in PLoS pathogens (01.12.2023)
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An approved in vitro approach to preclinical safety and efficacy evaluation of engineered T cell receptor anti-CD3 bispecific (ImmTAC) molecules
Harper, Jane, Adams, Katherine J, Bossi, Giovanna, Wright, Debbie E, Stacey, Andrea R, Bedke, Nicole, Martinez-Hague, Ruth, Blat, Dan, Humbert, Laure, Buchanan, Hazel, Le Provost, Gabrielle S, Donnellan, Zoe, Carreira, Ricardo J, Paston, Samantha J, Weigand, Luise U, Canestraro, Martina, Sanderson, Joseph P, Botta Gordon-Smith, Sophie, Lowe, Kate L, Rygiel, Karolina A, Powlesland, Alex S, Vuidepot, Annelise, Hassan, Namir J, Cameron, Brian J, Jakobsen, Bent K, Dukes, Joseph
Published in PloS one (15.10.2018)
Published in PloS one (15.10.2018)
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Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor
Cole, David K., Yuan, Fang, Rizkallah, Pierre J., Miles, John J., Gostick, Emma, Price, David A., Gao, George F., Jakobsen, Bent K., Sewell, Andrew K.
Published in The Journal of biological chemistry (02.10.2009)
Published in The Journal of biological chemistry (02.10.2009)
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Human TCR-Binding Affinity is Governed by MHC Class Restriction
Cole, David K, Pumphrey, Nicholas J, Boulter, Jonathan M, Sami, Malkit, Bell, John I, Gostick, Emma, Price, David A, Gao, George F, Sewell, Andrew K, Jakobsen, Bent K
Published in Journal of Immunology (01.05.2007)
Published in Journal of Immunology (01.05.2007)
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Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells
Mansour, Salah, Tocheva, Anna S., Cave-Ayland, Chris, Machelett, Moritz M., Sander, Barbara, Lissin, Nikolai M., Molloy, Peter E., Baird, Mark S., Stübs, Gunthard, Schröder, Nicolas W. J., Schumann, Ralf R., Rademann, Jörg, Postle, Anthony D., Jakobsen, Bent K., Marshall, Ben G., Gosain, Rajendra, Elkington, Paul T., Elliott, Tim, Skylaris, Chris-Kriton, Essex, Jonathan W., Tews, Ivo, Gadola, Stephan D.
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2016)
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Examining the presentation of tumor-associated antigens on peptide-pulsed T2 cells
Bossi, Giovanna, Gerry, Andrew B, Paston, Samantha J, Sutton, Deborah H, Hassan, Namir J, Jakobsen, Bent K
Published in Oncoimmunology (01.11.2013)
Published in Oncoimmunology (01.11.2013)
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The tumor targeted superantigen ABR-217620 selectively engages TRBV7-9 and exploits TCR-pMHC affinity mimicry in mediating T cell cytotoxicity
Hedlund, Gunnar, Eriksson, Helena, Sundstedt, Anette, Forsberg, Göran, Jakobsen, Bent K, Pumphrey, Nicholas, Rödström, Karin, Lindkvist-Petersson, Karin, Björk, Per
Published in PloS one (23.10.2013)
Published in PloS one (23.10.2013)
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Novel TCR-based biologics: mobilising T cells to warm ‘cold’ tumours
Lowe, Kate L., Cole, David, Kenefeck, Rupert, OKelly, Ita, Lepore, Marco, Jakobsen, Bent K.
Published in Cancer treatment reviews (01.07.2019)
Published in Cancer treatment reviews (01.07.2019)
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NY-ESO-1–specific TCR–engineered T cells mediate sustained antigen-specific antitumor effects in myeloma
Rapoport, Aaron P, Stadtmauer, Edward A, Binder-Scholl, Gwendolyn K, Goloubeva, Olga, Vogl, Dan T, Lacey, Simon F, Badros, Ashraf Z, Garfall, Alfred, Weiss, Brendan, Finklestein, Jeffrey, Kulikovskaya, Irina, Sinha, Sanjoy K, Kronsberg, Shari, Gupta, Minnal, Bond, Sarah, Melchiori, Luca, Brewer, Joanna E, Bennett, Alan D, Gerry, Andrew B, Pumphrey, Nicholas J, Williams, Daniel, Tayton- Martin, Helen K, Ribeiro, Lilliam, Holdich, Tom, Yanovich, Saul, Hardy, Nancy, Yared, Jean, Kerr, Naseem, Philip, Sunita, Westphal, Sandra, Siegel, Don L, Levine, Bruce L, Jakobsen, Bent K, Kalos, Michael, June, Carl H
Published in Nature medicine (01.08.2015)
Published in Nature medicine (01.08.2015)
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Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma
Linette, Gerald P., Stadtmauer, Edward A., Maus, Marcela V., Rapoport, Aaron P., Levine, Bruce L., Emery, Lyndsey, Litzky, Leslie, Bagg, Adam, Carreno, Beatriz M., Cimino, Patrick J., Binder-Scholl, Gwendolyn K., Smethurst, Dominic P., Gerry, Andrew B., Pumphrey, Nick J., Bennett, Alan D., Brewer, Joanna E., Dukes, Joseph, Harper, Jane, Tayton-Martin, Helen K., Jakobsen, Bent K., Hassan, Namir J., Kalos, Michael, June, Carl H.
Published in Blood (08.08.2013)
Published in Blood (08.08.2013)
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Fludarabine and neurotoxicity in engineered T-cell therapy
Lowe, Kate L., Mackall, Crystal L., Norry, Elliot, Amado, Rafael, Jakobsen, Bent K., Binder, Gwendolyn
Published in Gene therapy (01.06.2018)
Published in Gene therapy (01.06.2018)
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Polyfunctional response by ImmTAC (IMCgp100) redirected CD8+ and CD4+ T cells
Boudousquie, Caroline, Bossi, Giovanna, Hurst, Jacob M., Rygiel, Karolina A., Jakobsen, Bent K., Hassan, Namir J.
Published in Immunology (01.11.2017)
Published in Immunology (01.11.2017)
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TCR Binding to Peptide-MHC Stabilizes a Flexible Recognition Interface
Willcox, Benjamin E, Gao, George F, Wyer, Jessica R, Ladbury, John E, Bell, John I, Jakobsen, Bent K, van der Merwe, P.Anton
Published in Immunity (Cambridge, Mass.) (01.03.1999)
Published in Immunity (Cambridge, Mass.) (01.03.1999)
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Different affinity windows for virus and cancer‐specific T‐cell receptors: Implications for therapeutic strategies
Aleksic, Milos, Liddy, Nathaniel, Molloy, Peter E., Pumphrey, Nick, Vuidepot, Annelise, Chang, Kyong‐Mi, Jakobsen, Bent K.
Published in European journal of immunology (01.12.2012)
Published in European journal of immunology (01.12.2012)
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Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells
Cameron, Brian J, Gerry, Andrew B, Dukes, Joseph, Harper, Jane V, Kannan, Vivekanandan, Bianchi, Frayne C, Grand, Francis, Brewer, Joanna E, Gupta, Minnal, Plesa, Gabriela, Bossi, Giovanna, Vuidepot, Annelise, Powlesland, Alex S, Legg, Alison, Adams, Katherine J, Bennett, Alan D, Pumphrey, Nicholas J, Williams, Daniel D, Binder-Scholl, Gwendolyn, Kulikovskaya, Irina, Levine, Bruce L, Riley, James L, Varela-Rohena, Angel, Stadtmauer, Edward A, Rapoport, Aaron P, Linette, Gerald P, June, Carl H, Hassan, Namir J, Kalos, Michael, Jakobsen, Bent K
Published in Science translational medicine (07.08.2013)
Published in Science translational medicine (07.08.2013)
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Design of Soluble Recombinant T Cell Receptors for Antigen Targeting and T Cell Inhibition
Laugel, Bruno, Boulter, Jonathan M., Lissin, Nikolai, Vuidepot, Annelise, Li, Yi, Gostick, Emma, Crotty, Laura E., Douek, Daniel C., Hemelaar, Joris, Price, David A., Jakobsen, Bent K., Sewell, Andrew K.
Published in The Journal of biological chemistry (21.01.2005)
Published in The Journal of biological chemistry (21.01.2005)
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The CD8 T Cell Coreceptor Exhibits Disproportionate Biological Activity at Extremely Low Binding Affinities
Hutchinson, Sarah L, Wooldridge, Linda, Tafuro, Sabrina, Laugel, Bruno, Glick, Meir, Boulter, Jonathan M, Jakobsen, Bent K, Price, David A, Sewell, Andrew K
Published in The Journal of biological chemistry (04.07.2003)
Published in The Journal of biological chemistry (04.07.2003)
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High Avidity Antigen-Specific CTL Identified by CD8-Independent Tetramer Staining
Choi, Ed Man-Lik, Chen, Ji-Li, Wooldridge, Linda, Salio, Mariolina, Lissina, Anna, Lissin, Nikolai, Hermans, Ian F, Silk, Jonathan D, Mirza, Fareed, Palmowski, Michael J, Dunbar, P. Rod, Jakobsen, Bent K, Sewell, Andy K, Cerundolo, Vincenzo
Published in The Journal of immunology (1950) (15.11.2003)
Published in The Journal of immunology (1950) (15.11.2003)
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