Digital twins to personalize medicine
Björnsson, Bergthor, Borrebaeck, Carl, Elander, Nils, Gasslander, Thomas, Gawel, Danuta R, Gustafsson, Mika, Jörnsten, Rebecka, Lee, Eun Jung, Li, Xinxiu, Lilja, Sandra, Martínez-Enguita, David, Matussek, Andreas, Sandström, Per, Schäfer, Samuel, Stenmarker, Margaretha, Sun, X F, Sysoev, Oleg, Zhang, Huan, Benson, Mikael
Published in Genome medicine (31.12.2019)
Published in Genome medicine (31.12.2019)
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An interactive atlas of genomic, proteomic, and metabolomic biomarkers promotes the potential of proteins to predict complex diseases
Smelik, Martin, Zhao, Yelin, Li, Xinxiu, Loscalzo, Joseph, Sysoev, Oleg, Mahmud, Firoj, Mansour Aly, Dina, Benson, Mikael
Published in Scientific reports (03.06.2024)
Published in Scientific reports (03.06.2024)
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Network properties of complex human disease genes identified through genome-wide association studies
Barrenas, Fredrik, Chavali, Sreenivas, Holme, Petter, Mobini, Reza, Benson, Mikael
Published in PloS one (30.11.2009)
Published in PloS one (30.11.2009)
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Transcript and protein signatures derived from shared molecular interactions across cancers are associated with mortality
Zhao, Yelin, Li, Xinxiu, Loscalzo, Joseph, Smelik, Martin, Sysoev, Oleg, Wang, Yunzhang, Mahmud, A K M Firoj, Mansour Aly, Dina, Benson, Mikael
Published in Journal of translational medicine (11.05.2024)
Published in Journal of translational medicine (11.05.2024)
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DNA methylation changes separate allergic patients from healthy controls and may reflect altered CD4+ T-cell population structure
Nestor, Colm E, Barrenäs, Fredrik, Wang, Hui, Lentini, Antonio, Zhang, Huan, Bruhn, Sören, Jörnsten, Rebecka, Langston, Michael A, Rogers, Gary, Gustafsson, Mika, Benson, Mikael
Published in PLoS genetics (01.01.2014)
Published in PLoS genetics (01.01.2014)
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Characterization of human thymic exosomes
Skogberg, Gabriel, Gudmundsdottir, Judith, van der Post, Sjoerd, Sandström, Kerstin, Bruhn, Sören, Benson, Mikael, Mincheva-Nilsson, Lucia, Baranov, Vladimir, Telemo, Esbjörn, Ekwall, Olov
Published in PloS one (02.07.2013)
Published in PloS one (02.07.2013)
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Estimating heritability and genetic correlations from large health datasets in the absence of genetic data
Jia, Gengjie, Li, Yu, Zhang, Hanxin, Chattopadhyay, Ishanu, Boeck Jensen, Anders, Blair, David R, Davis, Lea, Robinson, Peter N, Dahlén, Torsten, Brunak, Søren, Benson, Mikael, Edgren, Gustaf, Cox, Nancy J, Gao, Xin, Rzhetsky, Andrey
Published in Nature communications (03.12.2019)
Published in Nature communications (03.12.2019)
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A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targets
Li, Xinxiu, Lee, Eun Jung, Lilja, Sandra, Loscalzo, Joseph, Schäfer, Samuel, Smelik, Martin, Strobl, Maria Regina, Sysoev, Oleg, Wang, Hui, Zhang, Huan, Zhao, Yelin, Gawel, Danuta R, Bohle, Barbara, Benson, Mikael
Published in Genome medicine (06.05.2022)
Published in Genome medicine (06.05.2022)
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Journal Article
5-Hydroxymethylcytosine Remodeling Precedes Lineage Specification during Differentiation of Human CD4+ T Cells
Nestor, Colm E., Lentini, Antonio, Hägg Nilsson, Cathrine, Gawel, Danuta R., Gustafsson, Mika, Mattson, Lina, Wang, Hui, Rundquist, Olof, Meehan, Richard R., Klocke, Bernward, Seifert, Martin, Hauck, Stefanie M., Laumen, Helmut, Zhang, Huan, Benson, Mikael
Published in Cell reports (Cambridge) (12.07.2016)
Published in Cell reports (Cambridge) (12.07.2016)
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Journal Article
Translating genomic medicine to the clinic: challenges and opportunities
Zhang, Huan, Klareskog, Lars, Matussek, Andreas, Pfister, Stefan M, Benson, Mikael
Published in Genome medicine (22.02.2019)
Published in Genome medicine (22.02.2019)
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Journal Article
scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases
Schäfer, Samuel, Smelik, Martin, Sysoev, Oleg, Zhao, Yelin, Eklund, Desiré, Lilja, Sandra, Gustafsson, Mika, Heyn, Holger, Julia, Antonio, Kovács, István A, Loscalzo, Joseph, Marsal, Sara, Zhang, Huan, Li, Xinxiu, Gawel, Danuta, Wang, Hui, Benson, Mikael
Published in Genome medicine (20.03.2024)
Published in Genome medicine (20.03.2024)
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An algorithm-based meta-analysis of genome- and proteome-wide data identifies a combination of potential plasma biomarkers for colorectal cancer
Gawel, Danuta R, Lee, Eun Jung, Li, Xinxiu, Lilja, Sandra, Matussek, Andreas, Schäfer, Samuel, Olsen, Renate Slind, Stenmarker, Margaretha, Zhang, Huan, Benson, Mikael
Published in Scientific reports (30.10.2019)
Published in Scientific reports (30.10.2019)
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Journal Article
CD4+ T-cell DNA methylation changes during pregnancy significantly correlate with disease-associated methylation changes in autoimmune diseases
Badam, Tejaswi V., Hellberg, Sandra, Mehta, Ratnesh B., Lechner-Scott, Jeannette, Lea, Rodney A., Tost, Jorg, Mariette, Xavier, Svensson-Arvelund, Judit, Nestor, Colm E., Benson, Mikael, Berg, Göran, Jenmalm, Maria C., Gustafsson, Mika, Ernerudh, Jan
Published in Epigenetics (2022)
Published in Epigenetics (2022)
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Meta-Analysis of Expression Profiling Data Indicates Need for Combinatorial Biomarkers in Pediatric Ulcerative Colitis
Benson, Mikael, Schäfer, Samuel, Lilja, Sandra, Gawel, Danuta R., Lee, Eun Jung, Li, Xinxiu, Zhang, Huan
Published in Journal of immunology research (2020)
Published in Journal of immunology research (2020)
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Journal Article
MicroRNAs act complementarily to regulate disease-related mRNA modules in human diseases
Chavali, Sreenivas, Bruhn, Sören, Tiemann, Katrin, Saetrom, Pål, Barrenäs, Fredrik, Saito, Takaya, Kanduri, Kartiek, Wang, Hui, Benson, Mikael
Published in RNA (Cambridge) (01.11.2013)
Published in RNA (Cambridge) (01.11.2013)
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Journal Article
Dynamic Response Genes in CD4+ T Cells Reveal a Network of Interactive Proteins that Classifies Disease Activity in Multiple Sclerosis
Hellberg, Sandra, Eklund, Daniel, Gawel, Danuta R., Köpsén, Mattias, Zhang, Huan, Nestor, Colm E., Kockum, Ingrid, Olsson, Tomas, Skogh, Thomas, Kastbom, Alf, Sjöwall, Christopher, Vrethem, Magnus, Håkansson, Irene, Benson, Mikael, Jenmalm, Maria C., Gustafsson, Mika, Ernerudh, Jan
Published in Cell reports (Cambridge) (13.09.2016)
Published in Cell reports (Cambridge) (13.09.2016)
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Journal Article
LASSIM-A network inference toolbox for genome-wide mechanistic modeling
Magnusson, Rasmus, Mariotti, Guido Pio, Köpsén, Mattias, Lövfors, William, Gawel, Danuta R, Jörnsten, Rebecka, Linde, Jörg, Nordling, Torbjörn E M, Nyman, Elin, Schulze, Sylvie, Nestor, Colm E, Zhang, Huan, Cedersund, Gunnar, Benson, Mikael, Tjärnberg, Andreas, Gustafsson, Mika
Published in PLoS computational biology (01.06.2017)
Published in PLoS computational biology (01.06.2017)
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