LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept
Coskun, Tamer, Sloop, Kyle W., Loghin, Corina, Alsina-Fernandez, Jorge, Urva, Shweta, Bokvist, Krister B., Cui, Xuewei, Briere, Daniel A., Cabrera, Over, Roell, William C., Kuchibhotla, Uma, Moyers, Julie S., Benson, Charles T., Gimeno, Ruth E., D'Alessio, David A., Haupt, Axel
Published in Molecular metabolism (Germany) (01.12.2018)
Published in Molecular metabolism (Germany) (01.12.2018)
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Journal Article
Myostatin antibody (LY2495655) in older weak fallers: a proof-of-concept, randomised, phase 2 trial
Becker, Clemens, Prof, Lord, Stephen R, Prof, Studenski, Stephanie A, MD, Warden, Stuart J, PhD, Fielding, Roger A, Prof, Recknor, Christopher P, MD, Hochberg, Marc C, Prof, Ferrari, Serge L, Prof, Blain, Hubert, Prof, Binder, Ellen F, Prof, Rolland, Yves, Prof, Poiraudeau, Serge, Prof, Benson, Charles T, MD, Myers, Stephen L, MD, Hu, Leijun, PhD, Ahmad, Qasim I, MD, Pacuch, Kelli R, Gomez, Elisa V, MS, Benichou, Olivier, Dr
Published in The lancet. Diabetes & endocrinology (01.12.2015)
Published in The lancet. Diabetes & endocrinology (01.12.2015)
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Journal Article
Cardiac Safety Research Consortium: Can the thorough QT/QTc study be replaced by early QT assessment in routine clinical pharmacology studies? Scientific update and a research proposal for a path forward
Darpo, Borje, MD, PhD, Garnett, Christine, PharmD, Benson, Charles T., MD, PhD, Keirns, James, PhD, Leishman, Derek, PhD, Malik, Marek, MD, PhD, Mehrotra, Nitin, PhD, Prasad, Krishna, MD, FRCP, Riley, Steve, PharmD, PhD, Rodriguez, Ignacio, MD, Sager, Philip, MD, Sarapa, Nenad, MD, Wallis, Robert, PhD
Published in The American heart journal (01.09.2014)
Published in The American heart journal (01.09.2014)
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Journal Article
LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial
Urva, Shweta, Coskun, Tamer, Loh, Mei Teng, Du, Yu, Thomas, Melissa K, Gurbuz, Sirel, Haupt, Axel, Benson, Charles T, Hernandez-Illas, Martha, D’Alessio, David A, Milicevic, Zvonko
Published in The Lancet (British edition) (26.11.2022)
Published in The Lancet (British edition) (26.11.2022)
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Journal Article
A Randomized, Double‐Blind Phase 2 Clinical Trial of Blosozumab, a Sclerostin Antibody, in Postmenopausal Women with Low Bone Mineral Density
Recker, Robert R., Benson, Charles T., Matsumoto, Toshio, Bolognese, Michael A., Robins, Deborah A., Alam, Jahangir, Chiang, Alan Y, Hu, Leijun, Krege, John H, Sowa, Hideaki, Mitlak, Bruce H., Myers, Stephen L.
Published in Journal of bone and mineral research (01.02.2015)
Published in Journal of bone and mineral research (01.02.2015)
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Journal Article
1588-P: Translatable Modeling of Glucagon Actions in Human iPSC-Derived Hepatocytes Uniquely Predicts Differential Clinical Responses to Glucagon Analog Agonist Molecules
ROELL, WILLIAM, REGMI, AJIT, BENSON, CHARLES T., COSKUN, TAMER, MOYERS, JULIE S., ALSINA-FERNANDEZ, JORGE, THOMAS, MELISSA K.
Published in Diabetes (New York, N.Y.) (20.06.2023)
Published in Diabetes (New York, N.Y.) (20.06.2023)
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Journal Article
A long‐acting glucose‐dependent insulinotropic polypeptide receptor agonist improves the gastrointestinal tolerability of glucagon‐like peptide‐1 receptor agonist therapy
Knop, Filip K., Urva, Shweta, Rettiganti, Mallikarjuna, Benson, Charles T., Roell, William C., Mather, Kieren J., Haupt, Axel, Pratt, Edward John
Published in Diabetes, obesity & metabolism (01.11.2024)
Published in Diabetes, obesity & metabolism (01.11.2024)
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Journal Article
Time for a Fully Integrated Nonclinical–Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective
Vargas, Hugo M., Rolf, Michael G., Wisialowski, Todd A., Achanzar, William, Bahinski, Anthony, Bass, Alan, Benson, Charles T, Chaudhary, Khuram W., Couvreur, Nicolas, Dota, Corina, Engwall, Michael J, Michael Foley, C., Gallacher, David, Greiter‐Wilke, Andrea, Guillon, Jean‐Michel, Guth, Brian, Himmel, Herbert M., Hegele‐Hartung, Christa, Ito, Maki, Jenkinson, Stephen, Chiba, Katsuyoshi, Lagrutta, Armando, Levesque, Paul, Martel, Eric, Okai, Yoshiko, Peri, Ravikumar, Pointon, Amy, Qu, Yusheng, Teisman, Ard, Traebert, Martin, Yoshinaga, Takashi, Gintant, Gary A., Leishman, Derek J., Valentin, Jean‐Pierre
Published in Clinical pharmacology and therapeutics (01.02.2021)
Published in Clinical pharmacology and therapeutics (01.02.2021)
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Journal Article
The Effect of Discontinuing Treatment With Blosozumab: Follow‐up Results of a Phase 2 Randomized Clinical Trial in Postmenopausal Women With Low Bone Mineral Density
Recknor, Christopher P, Recker, Robert R, Benson, Charles T, Robins, Deborah A, Chiang, Alan Y, Alam, Jahangir, Hu, Leijun, Matsumoto, Toshio, Sowa, Hideaki, Sloan, John H, Konrad, Robert J, Mitlak, Bruce H, Sipos, Adrien A
Published in Journal of bone and mineral research (01.09.2015)
Published in Journal of bone and mineral research (01.09.2015)
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Journal Article
Effect of Food Consumption on the Pharmacokinetics, Safety, and Tolerability of Once-Daily Orally Administered Orforglipron (LY3502970), a Non-peptide GLP-1 Receptor Agonist
Ma, Xiaosu, Liu, Rong, Pratt, Edward J., Benson, Charles T., Bhattachar, Shobha N., Sloop, Kyle W.
Published in Diabetes therapy (01.04.2024)
Published in Diabetes therapy (01.04.2024)
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Journal Article
Pharmacokinetics and Pharmacodynamics of Human Regular U-500 Insulin Administered via Continuous Subcutaneous Insulin Infusion Versus Subcutaneous Injection in Adults With Type 2 Diabetes and High-Dose Insulin Requirements
Ma, Xiaosu, Benson, Charles T., Prescilla, Randy, Zhang, Shuyu, Linnebjerg, Helle, LaBell, Elizabeth S., Morrow, Linda A., Jackson, Jeffrey A., Nguyen, Alex, Ilag, Liza L., Johnson, Jennal L., Leishman, Derek
Published in Journal of diabetes science and technology (01.03.2022)
Published in Journal of diabetes science and technology (01.03.2022)
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Journal Article
Shared Learnings on the New EMA First-in-Human and Early Clinical Trial Guideline: Proceedings From a DIAlogue Session at DIA Europe 2018
van der Laan, Jan Willem, Benson, Charles T., Janssens, Walter, Bos, Jeroen, Stahl, Elke, Brady, Joseph T., Wändel-Liminga, Ulla, Corriol-Rohou, Solange, Forster, Roy, Hartmann, Andreas, Pertel, Peter Einar, Robertson, Sarah M., Silva-Lima, Beatriz, Malik, Raleigh E., Chibout, Salah-Dine
Published in Therapeutic innovation & regulatory science (01.03.2020)
Published in Therapeutic innovation & regulatory science (01.03.2020)
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Journal Article
Teriparatide has no effect on the calcium-mediated pharmacodynamics of digoxin
Benson, Charles T, Voelker, James R
Published in Clinical pharmacology and therapeutics (01.01.2003)
Published in Clinical pharmacology and therapeutics (01.01.2003)
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Journal Article
Water Permeability and Its Activation Energy for Individual Hamster Pancreatic Islet Cells
Liu, Chi, Benson, Charles T., Gao, Dayong, Haag, Brian W., McGann, Locksley E., Critser, John K.
Published in Cryobiology (01.10.1995)
Published in Cryobiology (01.10.1995)
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Journal Article
Pharmacokinetics and Pharmacodynamics of Human Regular U-500 Insulin Administered via Continuous Subcutaneous Insulin Infusion vs. Subcutaneous Injection in Adults with Type 2 Diabetes and High Insulin Requirements
Ma, Xiaosu, Benson, Charles T., Prescilla, Randy, Zhang, Shuyu, Linnebjerg, Helle, Labell, Elizabeth S., Morrow, Linda, Jackson, Jeffrey A., Nguyen, Alex, Johnson, Jennal, Leishman, Derek
Published in Canadian journal of diabetes (01.10.2018)
Published in Canadian journal of diabetes (01.10.2018)
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Journal Article
136 - Pharmacokinetics and Pharmacodynamics of Human Regular U-500 Insulin Administered via Continuous Subcutaneous Insulin Infusion vs. Subcutaneous Injection in Adults with Type 2 Diabetes and High Insulin Requirements
Ma, Xiaosu, Benson, Charles T., Prescilla, Randy, Zhang, Shuyu, Linnebjerg, Helle, Labell, Elizabeth S., Morrow, Linda, Jackson, Jeffrey A., Nguyen, Alex, Johnson, Jennal, Leishman, Derek
Published in Canadian journal of diabetes (01.10.2018)
Published in Canadian journal of diabetes (01.10.2018)
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Journal Article