Raloxifene (LY139481 HCl) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats
BLACK, L. J, SATO, M, FROLIK, C. A, TERMINE, J. D, BRYANT, H. U, ROWLEY, E. R, MAGEE, D. E, BEKELE, A, WILLIAMS, D. C, CULLINAN, G. J, BENDELE, R, KAUFFMAN, R. F, BENSCH, W. R
Published in The Journal of clinical investigation (1994)
Published in The Journal of clinical investigation (1994)
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Inhibition of cholesteryl ester transfer protein in normocholesterolemic and hypercholesterolemic hamsters: effects on HDL subspecies, quantity, and apolipoprotein distribution
Evans, G F, Bensch, W R, Apelgren, L D, Bailey, D, Kauffman, R F, Bumol, T F, Zuckerman, S H
Published in Journal of lipid research (01.09.1994)
Published in Journal of lipid research (01.09.1994)
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Phospholipid Transfer Protein Is Regulated by Liver X Receptors in Vivo
Cao, Guoqing, Beyer, Thomas P, Yang, Xiao Ping, Schmidt, Robert J, Zhang, Youyan, Bensch, William R, Kauffman, Raymond F, Gao, Hong, Ryan, Timothy P, Liang, Yu, Eacho, Patrick I, Jiang, Xian-Cheng
Published in The Journal of biological chemistry (18.10.2002)
Published in The Journal of biological chemistry (18.10.2002)
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Synthesis and Biological Evaluation of a New Series of Sterols as Potential Hypocholesterolemic Agents
Lin, Ho-Shen, Rampersaud, Ashraff A, Archer, Robert A, Pawlak, Joseph M, Beavers, Lisa S, Schmidt, Robert J, Kauffman, Raymond F, Bensch, William R, Bumol, Thomas F
Published in Journal of medicinal chemistry (01.01.1995)
Published in Journal of medicinal chemistry (01.01.1995)
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Enlargement of High Density Lipoprotein in Mice via Liver X Receptor Activation Requires Apolipoprotein E and Is Abolished by Cholesteryl Ester Transfer Protein Expression
Jiang, Xian-Cheng, Beyer, Thomas P., Li, Zhiqiang, Liu, Jin, Quan, Wei, Schmidt, Robert J., Zhang, Youyan, Bensch, William R., Eacho, Patrick I., Cao, Guoqing
Published in The Journal of biological chemistry (05.12.2003)
Published in The Journal of biological chemistry (05.12.2003)
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Hypocholesterolemic Activity of Raloxifene (LY139481): Pharmacological Characterization as a Selective Estrogen Receptor Modulator
Kauffman, R F, Bensch, W R, Roudebush, R E, Cole, H W, Bean, J S, Phillips, D L, Monroe, A, Cullinan, G J, Glasebrook, A L, Bryant, H U
Published in The Journal of pharmacology and experimental therapeutics (01.01.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.01.1997)
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Raloxifene and estrogen inhibit neointimal thickening after balloon injury in the carotid artery of male and ovariectomized female rats
Kauffman, R F, Bean, J S, Fahey, K J, Cullinan, G J, Cox, D A, Bensch, W R
Published in Journal of cardiovascular pharmacology (01.10.2000)
Published in Journal of cardiovascular pharmacology (01.10.2000)
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Effects of LY295427, a Low-Density Lipoprotein (LDL) Receptor Up-Regulator, on LDL Receptor Gene Transcription and Cholesterol Metabolism in Normal and Hypercholesterolemic Hamsters
Bensch, W R, Gadski, R A, Bean, J S, Beavers, L S, Schmidt, R J, Perry, D N, Murphy, A T, McClure, D B, Eacho, P I, Breau, A P, Archer, R A, Kauffman, R F
Published in The Journal of pharmacology and experimental therapeutics (01.04.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.04.1999)
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Lack of correlation between the rate of cholesterol biosynthesis and the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rats and in fibroblasts treated with ML-236B
Bensch, W.R., Ingebritsen, T.S., Diller, E.R.
Published in Biochemical and biophysical research communications (01.01.1978)
Published in Biochemical and biophysical research communications (01.01.1978)
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A Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist with a Unique in Vitro Profile and Potent Glucose and Lipid Effects in Rodent Models of Type 2 Diabetes and Dyslipidemia
Reifel-Miller, Anne, Otto, Keith, Hawkins, Eric, Barr, Robert, Bensch, William R, Bull, Chris, Dana, Sharon, Klausing, Kay, Martin, Jose-Alfredo, Rafaeloff-Phail, Ronit, Rafizadeh-Montrose, Chahrzad, Rhodes, Gary, Robey, Roger, Rojo, Isabel, Rungta, Deepa, Snyder, David, Wilbur, Kelly, Zhang, Tony, Zink, Richard, Warshawsky, Alan, Brozinick, Joseph T
Published in Molecular endocrinology (Baltimore, Md.) (01.06.2005)
Published in Molecular endocrinology (Baltimore, Md.) (01.06.2005)
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Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist
Xu, Yanping, Mayhugh, Daniel, Saeed, Ashraf, Wang, Xiaodong, Thompson, Richard C, Dominianni, Samuel J, Kauffman, Raymond F, Singh, Jaipal, Bean, James S, Bensch, William R, Barr, Robert J, Osborne, John, Montrose-Rafizadeh, Chahrzad, Zink, Richard W, Yumibe, Nathan P, Huang, Naijia, Luffer-Atlas, Debra, Rungta, Deepa, Maise, Dale E, Mantlo, Nathan B
Published in Journal of medicinal chemistry (20.11.2003)
Published in Journal of medicinal chemistry (20.11.2003)
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A tailored therapy for the metabolic syndrome: The dual peroxisome proliferator-activated receptor-α/γ agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while improving cardiovascular risk factors in preclinical models
ETGEN, Garret J, OLDHAM, Brian A, SHUKER, Anthony J, RITO, Christopher J, MCCARTHY, James R, ARDECKY, Robert J, TYHONAS, John S, DANA, Sharon L, BILAKOVICS, James M, PATERNITI, James R, OGILVIE, Kathleen M, SHA LIU, JOHNSON, William T, KAUFFMAN, Raymond F, BRODERICK, Carol L, MONTROSE, Chahrzad R, BROZINICK, Joseph T, MISENER, Elizabeth A, BEAN, James S, BENSCH, William R, BROOKS, Dawn A
Published in Diabetes (New York, N.Y.) (01.04.2002)
Published in Diabetes (New York, N.Y.) (01.04.2002)
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Coadministration of a liver X receptor agonist and a peroxisome proliferator activator receptor-alpha agonist in Mice: effects of nuclear receptor interplay on high-density lipoprotein and triglyceride metabolism in vivo
Beyer, Thomas P, Schmidt, Robert J, Foxworthy, Patricia, Zhang, Youyan, Dai, Jiannong, Bensch, William R, Kauffman, Raymond F, Gao, Hong, Ryan, Timothy P, Jiang, Xian-Cheng, Karathanasis, Sotirios K, Eacho, Patrick I, Cao, Guoqing
Published in The Journal of pharmacology and experimental therapeutics (01.06.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2004)
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Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids: A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/γ Agonists
Xu, Yanping, Rito, Christopher J, Etgen, Garret J, Ardecky, Robert J, Bean, James S, Bensch, William R, Bosley, Jacob R, Broderick, Carol L, Brooks, Dawn A, Dominianni, Samuel J, Hahn, Patric J, Liu, Sha, Mais, Dale E, Montrose-Rafizadeh, Chahrzad, Ogilvie, Kathy M, Oldham, Brian A, Peters, Mary, Rungta, Deepa K, Shuker, Anthony J, Stephenson, Gregory A, Tripp, Allie E, Wilson, Sarah B, Winneroski, Leonard L, Zink, Richard, Kauffman, Raymond F, McCarthy, James R
Published in Journal of medicinal chemistry (06.05.2004)
Published in Journal of medicinal chemistry (06.05.2004)
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Journal Article
Lack of correlation between the rate of cholesterol biosynthesis and the activity of 3-hydroxy-3-methylgutaryl coenzyme A reductase in rats and in fibroblasts treated with ML-236B
Bensch, W R, Ingebritsen, T S, Diller, E R
Published in Biochemical and biophysical research communications (15.05.1978)
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Published in Biochemical and biophysical research communications (15.05.1978)
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