E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia
Benini, Monica, Fortuni, Silvia, Condò, Ivano, Alfedi, Giulia, Malisan, Florence, Toschi, Nicola, Serio, Dario, Massaro, Damiano Sergio, Arcuri, Gaetano, Testi, Roberto, Rufini, Alessandra
Published in Cell reports (Cambridge) (21.02.2017)
Published in Cell reports (Cambridge) (21.02.2017)
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Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells
Rufini, Alessandra, Cavallo, Francesca, Condò, Ivano, Fortuni, Silvia, De Martino, Gabriella, Incani, Ottaviano, Di Venere, Almerinda, Benini, Monica, Massaro, Damiano Sergio, Arcuri, Gaetano, Serio, Dario, Malisan, Florence, Testi, Roberto
Published in Neurobiology of disease (01.03.2015)
Published in Neurobiology of disease (01.03.2015)
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Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich's ataxia
Alfedi, Giulia, Luffarelli, Riccardo, Condò, Ivano, Pedini, Giorgia, Mannucci, Liliana, Massaro, Damiano S., Benini, Monica, Toschi, Nicola, Alaimo, Giorgia, Panarello, Luca, Pacini, Laura, Fortuni, Silvia, Serio, Dario, Malisan, Florence, Testi, Roberto, Rufini, Alessandra
Published in Movement disorders (01.03.2019)
Published in Movement disorders (01.03.2019)
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Frataxin deficiency in Friedreich’s ataxia is associated with reduced levels of HAX-1, a regulator of cardiomyocyte death and survival
Tiano, Francesca, Amati, Francesca, Cherubini, Fabio, Morini, Elena, Vancheri, Chiara, Maletta, Sara, Fortuni, Silvia, Serio, Dario, Quatrana, Andrea, Luffarelli, Riccardo, Benini, Monica, Alfedi, Giulia, Panarello, Luca, Rufini, Alessandra, Toschi, Nicola, Frontali, Marina, Romano, Silvia, Marcotulli, Christian, Casali, Carlo, Gioiosa, Silvia, Mariotti, Caterina, Mongelli, Alessia, Fichera, Mario, Condò, Ivano, Novelli, Giuseppe, Testi, Roberto, Malisan, Florence
Published in Human molecular genetics (01.02.2020)
Published in Human molecular genetics (01.02.2020)
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Biophysical characterisation of the recombinant human frataxin precursor
Castro, Ignacio Hugo, Ferrari, Alejandro, Herrera, María Georgina, Noguera, Martín Ezequiel, Maso, Lorenzo, Benini, Monica, Rufini, Alessandra, Testi, Roberto, Costantini, Paola, Santos, Javier
Published in FEBS open bio (01.03.2018)
Published in FEBS open bio (01.03.2018)
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