Targeted Degradation of Structured RNAs via Ribonuclease-Targeting Chimeras (RiboTacs)
Haj-Yahia, Salma, Nandi, Arijit, Benhamou, Raphael I
Published in Expert opinion on drug discovery (03.08.2023)
Published in Expert opinion on drug discovery (03.08.2023)
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Journal Article
Di-N-Methylation of Anti-Gram-Positive Aminoglycoside-Derived Membrane Disruptors Improves Antimicrobial Potency and Broadens Spectrum to Gram-Negative Bacteria
Benhamou, Raphael I., Shaul, Pazit, Herzog, Ido M., Fridman, Micha
Published in Angewandte Chemie International Edition (09.11.2015)
Published in Angewandte Chemie International Edition (09.11.2015)
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Journal Article
Targeting the SARS-CoV‑2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders
Haniff, Hafeez S, Tong, Yuquan, Liu, Xiaohui, Chen, Jonathan L, Suresh, Blessy M, Andrews, Ryan J, Peterson, Jake M, O’Leary, Collin A, Benhamou, Raphael I, Moss, Walter N, Disney, Matthew D
Published in ACS central science (28.10.2020)
Published in ACS central science (28.10.2020)
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Journal Article
Fluorescent Tracking of the Endoplasmic Reticulum in Live Pathogenic Fungal Cells
Benhamou, Raphael I, Jaber, Qais Z, Herzog, Ido M, Roichman, Yael, Fridman, Micha
Published in ACS chemical biology (21.12.2018)
Published in ACS chemical biology (21.12.2018)
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Journal Article
Real-Time Imaging of the Azole Class of Antifungal Drugs in Live Candida Cells
Benhamou, Raphael I, Bibi, Maayan, Steinbuch, Kfir B, Engel, Hamutal, Levin, Maayan, Roichman, Yael, Berman, Judith, Fridman, Micha
Published in ACS chemical biology (21.07.2017)
Published in ACS chemical biology (21.07.2017)
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Journal Article
Bacterial-derived exopolysaccharides enhance antifungal drug tolerance in a cross-kingdom oral biofilm
Kim, Dongyeop, Liu, Yuan, Benhamou, Raphael I., Sanchez, Hiram, Simón-Soro, Áurea, Li, Yong, Hwang, Geelsu, Fridman, Micha, Andes, David R., Koo, Hyun
Published in The ISME Journal (01.06.2018)
Published in The ISME Journal (01.06.2018)
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Journal Article
Localizing Antifungal Drugs to the Correct Organelle Can Markedly Enhance their Efficacy
Benhamou, Raphael I., Bibi, Maayan, Berman, Judith, Fridman, Micha
Published in Angewandte Chemie International Edition (22.05.2018)
Published in Angewandte Chemie International Edition (22.05.2018)
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Journal Article
Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment
Zhang, Peiyuan, Liu, Xiaohui, Abegg, Daniel, Tanaka, Toru, Tong, Yuquan, Benhamou, Raphael I, Baisden, Jared, Crynen, Gogce, Meyer, Samantha M, Cameron, Michael D, Chatterjee, Arnab K, Adibekian, Alexander, Childs-Disney, Jessica L, Disney, Matthew D
Published in Journal of the American Chemical Society (25.08.2021)
Published in Journal of the American Chemical Society (25.08.2021)
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Journal Article
Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus
Matzov, Donna, Eyal, Zohar, Benhamou, Raphael I, Shalev-Benami, Moran, Halfon, Yehuda, Krupkin, Miri, Zimmerman, Ella, Rozenberg, Haim, Bashan, Anat, Fridman, Micha, Yonath, Ada
Published in Nucleic acids research (29.09.2017)
Published in Nucleic acids research (29.09.2017)
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Journal Article
Programming inactive RNA-binding small molecules into bioactive degraders
Tong, Yuquan, Lee, Yeongju, Liu, Xiaohui, Childs-Disney, Jessica L., Suresh, Blessy M., Benhamou, Raphael I., Yang, Chunying, Li, Weimin, Costales, Matthew G., Haniff, Hafeez S., Sievers, Sonja, Abegg, Daniel, Wegner, Tristan, Paulisch, Tiffany O., Lekah, Elizabeth, Grefe, Maison, Crynen, Gogce, Van Meter, Montina, Wang, Tenghui, Gibaut, Quentin M. R., Cleveland, John L., Adibekian, Alexander, Glorius, Frank, Waldmann, Herbert, Disney, Matthew D.
Published in Nature (London) (01.06.2023)
Published in Nature (London) (01.06.2023)
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Journal Article
DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor
Benhamou, Raphael I, Suresh, Blessy M, Tong, Yuquan, Cochrane, Wesley G, Cavett, Valerie, Vezina-Dawod, Simon, Abegg, Daniel, Childs-Disney, Jessica L, Adibekian, Alexander, Paegel, Brian M, Disney, Matthew D
Published in Proceedings of the National Academy of Sciences - PNAS (08.02.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (08.02.2022)
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Journal Article
Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles
Elias, Rebecca, Benhamou, Raphael I., Jaber, Qais Z., Dorot, Orly, Zada, Sivan Louzoun, Oved, Keren, Pichinuk, Edward, Fridman, Micha
Published in European journal of medicinal chemistry (01.10.2019)
Published in European journal of medicinal chemistry (01.10.2019)
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Journal Article
Antifungal Imidazole-Decorated Cationic Amphiphiles with Markedly Low Hemolytic Activity
Benhamou, Raphael I., Steinbuch, Kfir B., Fridman, Micha
Published in Chemistry : a European journal (01.08.2016)
Published in Chemistry : a European journal (01.08.2016)
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Journal Article
A Druglike Small Molecule that Targets r(CCUG) Repeats in Myotonic Dystrophy Type 2 Facilitates Degradation by RNA Quality Control Pathways
Wagner-Griffin, Sarah, Abe, Masahito, Benhamou, Raphael I, Angelbello, Alicia J, Vishnu, Kamalakannan, Chen, Jonathan L, Childs-Disney, Jessica L, Disney, Matthew D
Published in Journal of medicinal chemistry (24.06.2021)
Published in Journal of medicinal chemistry (24.06.2021)
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Journal Article
A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex
Angelbello, Alicia J., Benhamou, Raphael I., Rzuczek, Suzanne G., Choudhary, Shruti, Tang, Zhenzhi, Chen, Jonathan L., Roy, Madhuparna, Wang, Kye Won, Yildirim, Ilyas, Jun, Albert S., Thornton, Charles A., Disney, Matthew D.
Published in Cell chemical biology (21.01.2021)
Published in Cell chemical biology (21.01.2021)
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