Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase
Grey, Ron, Pierce, Albert C., Bemis, Guy W., Jacobs, Marc D., Moody, Cameron Stuver, Jajoo, Rahul, Mohal, Narinder, Green, Jeremy
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
Get full text
Journal Article
Structure-Guided Design of Potent and Selective Pyrimidylpyrrole Inhibitors of Extracellular Signal-Regulated Kinase (ERK) Using Conformational Control
Aronov, Alex M, Tang, Qing, Martinez-Botella, Gabriel, Bemis, Guy W, Cao, Jingrong, Chen, Guanjing, Ewing, Nigel P, Ford, Pamella J, Germann, Ursula A, Green, Jeremy, Hale, Michael R, Jacobs, Marc, Janetka, James W, Maltais, Francois, Markland, William, Namchuk, Mark N, Nanthakumar, Suganthini, Poondru, Srinivasu, Straub, Judy, ter Haar, Ernst, Xie, Xiaoling
Published in Journal of medicinal chemistry (22.10.2009)
Published in Journal of medicinal chemistry (22.10.2009)
Get full text
Journal Article
Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors
Aronov, Alex M, Baker, Christopher, Bemis, Guy W, Cao, Jingrong, Chen, Guanjing, Ford, Pamella J, Germann, Ursula A, Green, Jeremy, Hale, Michael R, Jacobs, Marc, Janetka, James W, Maltais, Francois, Martinez-Botella, Gabriel, Namchuk, Mark N, Straub, Judy, Tang, Qing, Xie, Xiaoling
Published in Journal of medicinal chemistry (22.03.2007)
Published in Journal of medicinal chemistry (22.03.2007)
Get full text
Journal Article
The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor
Duffy, John P, Harrington, Edmund M, Salituro, Francesco G, Cochran, John E, Green, Jeremy, Gao, Huai, Bemis, Guy W, Evindar, Ghotas, Galullo, Vincent P, Ford, Pamella J, Germann, Ursula A, Wilson, Keith P, Bellon, Steven F, Chen, Guanging, Taslimi, Paul, Jones, Peter, Huang, Cassey, Pazhanisamy, S, Wang, Yow-Ming, Murcko, Mark A, Su, Michael S.S
Published in ACS medicinal chemistry letters (13.10.2011)
Published in ACS medicinal chemistry letters (13.10.2011)
Get full text
Journal Article
CORES: An Automated Method for Generating Three-Dimensional Models of Protein/Ligand Complexes
Hare, Brian J, Walters, W. Patrick, Caron, Paul R, Bemis, Guy W
Published in Journal of medicinal chemistry (09.09.2004)
Published in Journal of medicinal chemistry (09.09.2004)
Get full text
Journal Article
The SHAPES strategy: an NMR-based approach for lead generation in drug discovery
Fejzo, Jasna, Lepre, Christopher A, Peng, Jeffrey W, Bemis, Guy W, Ajay, Murcko, Mark A, Moore, Jonathan M
Published in Chemistry & biology (01.10.1999)
Published in Chemistry & biology (01.10.1999)
Get full text
Journal Article
Dramatic reversal of diastereoselectivity in an N-acyliminium ion cyclization leading to hexahydropyrrolo[2,1-a]isoquinolines. A case of competing steric interactions
Maryanoff, Bruce E, McComsey, David F, Almond, Harold R, Mutter, Martin S, Bemis, Guy W, Whittle, Robert R, Olofson, R. A
Published in Journal of organic chemistry (01.04.1986)
Published in Journal of organic chemistry (01.04.1986)
Get full text
Journal Article
A molecular dynamics study of the stability of chymotrypsin acyl enzymes
Bemis, Guy W, Carlson-Golab, Gail, Katzenellenbogen, John A
Published in Journal of the American Chemical Society (01.01.1992)
Published in Journal of the American Chemical Society (01.01.1992)
Get full text
Journal Article
The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
Wilson, Keith P., McCaffrey, Patricia G., Hsiao, Kathy, Pazhanisamy, Sam, Galullo, Vincent, Bemis, Guy W., Fitzgibbon, Matthew J., Caron, Paul R., Murcko, Mark A., Su, Michael S.S.
Published in Chemistry & biology (01.06.1997)
Published in Chemistry & biology (01.06.1997)
Get full text
Journal Article
UREA DERIVATIVES AS INHIBITORS OF IMPDH ENZYME
BEMIS GUY W, NOVAK PERRY M, BETHIEL RANDY S, RONKIN STEVEN M, SAUNDERS JEFFREY O, ARMISTEAD DAVID M, BADIA MICHAEL C, FRANK CATHARINE A
Year of Publication 15.02.2000
Get full text
Year of Publication 15.02.2000
Patent
Inhibitors of p38 MAP kinase: therapeutic intervention in cytokine-mediated diseases
Salituro, F G, Germann, U A, Wilson, K P, Bemis, G W, Fox, T, Su, M S
Published in Current medicinal chemistry (01.09.1999)
Published in Current medicinal chemistry (01.09.1999)
Get more information
Journal Article
Bile pigments as HIV-1 protease inhibitors and their effects on HIV-1 viral maturation and infectivity in vitro
McPhee, F, Caldera, P S, Bemis, G W, McDonagh, A F, Kuntz, I D, Craik, C S
Published in Biochemical journal (01.12.1996)
Published in Biochemical journal (01.12.1996)
Get full text
Journal Article