Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity
Mobbs, Jesse I, Belousoff, Matthew J, Harikumar, Kaleeckal G, Piper, Sarah J, Xu, Xiaomeng, Furness, Sebastian G B, Venugopal, Hari, Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Thal, David M, Miller, Laurence J, Sexton, Patrick M
Published in PLoS biology (01.06.2021)
Published in PLoS biology (01.06.2021)
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Journal Article
Routine sub-2.5 Å cryo-EM structure determination of GPCRs
Danev, Radostin, Belousoff, Matthew, Liang, Yi-Lynn, Zhang, Xin, Eisenstein, Fabian, Wootten, Denise, Sexton, Patrick M.
Published in Nature communications (15.07.2021)
Published in Nature communications (15.07.2021)
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Journal Article
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists
Zhang, Xin, Belousoff, Matthew J., Zhao, Peishen, Kooistra, Albert J., Truong, Tin T., Ang, Sheng Yu, Underwood, Christina Rye, Egebjerg, Thomas, Šenel, Petr, Stewart, Gregory D., Liang, Yi-Lynn, Glukhova, Alisa, Venugopal, Hari, Christopoulos, Arthur, Furness, Sebastian G.B., Miller, Laurence J., Reedtz-Runge, Steffen, Langmead, Christopher J., Gloriam, David E., Danev, Radostin, Sexton, Patrick M., Wootten, Denise
Published in Molecular cell (05.11.2020)
Published in Molecular cell (05.11.2020)
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Journal Article
Activation of the GLP-1 receptor by a non-peptidic agonist
Zhao, Peishen, Liang, Yi-Lynn, Belousoff, Matthew J., Deganutti, Giuseppe, Fletcher, Madeleine M., Willard, Francis S., Bell, Michael G., Christe, Michael E., Sloop, Kyle W., Inoue, Asuka, Truong, Tin T., Clydesdale, Lachlan, Furness, Sebastian G. B., Christopoulos, Arthur, Wang, Ming-Wei, Miller, Laurence J., Reynolds, Christopher A., Danev, Radostin, Sexton, Patrick M., Wootten, Denise
Published in Nature (London) (16.01.2020)
Published in Nature (London) (16.01.2020)
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Journal Article
Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation
Liang, Yi-Lynn, Belousoff, Matthew J., Zhao, Peishen, Koole, Cassandra, Fletcher, Madeleine M., Truong, Tin T., Julita, Villy, Christopoulos, George, Xu, H. Eric, Zhang, Yan, Khoshouei, Maryam, Christopoulos, Arthur, Danev, Radostin, Sexton, Patrick M., Wootten, Denise
Published in Molecular cell (06.02.2020)
Published in Molecular cell (06.02.2020)
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Journal Article
Structure and dynamics of the CGRP receptor in apo and peptide-bound forms
Josephs, Tracy M, Belousoff, Matthew J, Liang, Yi-Lynn, Piper, Sarah J, Cao, Jianjun, Garama, Daniel J, Leach, Katie, Gregory, Karen J, Christopoulos, Arthur, Hay, Debbie L, Danev, Radostin, Wootten, Denise, Sexton, Patrick M
Published in Science (American Association for the Advancement of Science) (09.04.2021)
Published in Science (American Association for the Advancement of Science) (09.04.2021)
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Journal Article
Evolving cryo-EM structural approaches for GPCR drug discovery
Zhang, Xin, Johnson, Rachel M., Drulyte, Ieva, Yu, Lingbo, Kotecha, Abhay, Danev, Radostin, Wootten, Denise, Sexton, Patrick M., Belousoff, Matthew J.
Published in Structure (London) (02.09.2021)
Published in Structure (London) (02.09.2021)
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Journal Article
Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes
Zhang, Xin, Belousoff, Matthew J., Liang, Yi-Lynn, Danev, Radostin, Sexton, Patrick M., Wootten, Denise
Published in Cell reports (Cambridge) (13.07.2021)
Published in Cell reports (Cambridge) (13.07.2021)
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Journal Article
The architecture and stabilisation of flagellotropic tailed bacteriophages
Hardy, Joshua M., Dunstan, Rhys A., Grinter, Rhys, Belousoff, Matthew J., Wang, Jiawei, Pickard, Derek, Venugopal, Hariprasad, Dougan, Gordon, Lithgow, Trevor, Coulibaly, Fasséli
Published in Nature communications (27.07.2020)
Published in Nature communications (27.07.2020)
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Journal Article
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
Deganutti, Giuseppe, Liang, Yi-Lynn, Zhang, Xin, Khoshouei, Maryam, Clydesdale, Lachlan, Belousoff, Matthew J., Venugopal, Hari, Truong, Tin T., Glukhova, Alisa, Keller, Andrew N., Gregory, Karen J., Leach, Katie, Christopoulos, Arthur, Danev, Radostin, Reynolds, Christopher A., Zhao, Peishen, Sexton, Patrick M., Wootten, Denise
Published in Nature communications (10.01.2022)
Published in Nature communications (10.01.2022)
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Journal Article
Global Trends in Proteome Remodeling of the Outer Membrane Modulate Antimicrobial Permeability in Klebsiella pneumoniae
Rocker, Andrea, Lacey, Jake A, Belousoff, Matthew J, Wilksch, Jonathan J, Strugnell, Richard A, Davies, Mark R, Lithgow, Trevor
Published in mBio (14.04.2020)
Published in mBio (14.04.2020)
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Journal Article
Structure and Membrane Topography of the Vibrio-Type Secretin Complex from the Type 2 Secretion System of Enteropathogenic Escherichia coli
Hay, Iain D, Belousoff, Matthew J, Dunstan, Rhys A, Bamert, Rebecca S, Lithgow, Trevor
Published in Journal of bacteriology (01.03.2018)
Published in Journal of bacteriology (01.03.2018)
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Journal Article
A structural basis for amylin receptor phenotype
Cao, Jianjun, Belousoff, Matthew J, Liang, Yi-Lynn, Johnson, Rachel M, Josephs, Tracy M, Fletcher, Madeleine M, Christopoulos, Arthur, Hay, Debbie L, Danev, Radostin, Wootten, Denise, Sexton, Patrick M
Published in Science (American Association for the Advancement of Science) (25.03.2022)
Published in Science (American Association for the Advancement of Science) (25.03.2022)
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Journal Article
Evolution of the Translocation and Assembly Module (TAM)
Heinz, Eva, Selkrig, Joel, Belousoff, Matthew J, Lithgow, Trevor
Published in Genome biology and evolution (01.06.2015)
Published in Genome biology and evolution (01.06.2015)
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Journal Article
Structure and dynamics of the active Gs-coupled human secretin receptor
Dong, Maoqing, Deganutti, Giuseppe, Piper, Sarah J., Liang, Yi-Lynn, Khoshouei, Maryam, Belousoff, Matthew J., Harikumar, Kaleeckal G., Reynolds, Christopher A., Glukhova, Alisa, Furness, Sebastian G. B., Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Sexton, Patrick M., Miller, Laurence J.
Published in Nature communications (18.08.2020)
Published in Nature communications (18.08.2020)
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Journal Article
Structural and functional diversity among agonist-bound states of the GLP-1 receptor
Cary, Brian P., Deganutti, Giuseppe, Zhao, Peishen, Truong, Tin T., Piper, Sarah J., Liu, Xinyu, Belousoff, Matthew J., Danev, Radostin, Sexton, Patrick M., Wootten, Denise, Gellman, Samuel H.
Published in Nature chemical biology (01.03.2022)
Published in Nature chemical biology (01.03.2022)
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Journal Article
Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling
Harikumar, Kaleeckal G, Zhao, Peishen, Cary, Brian P, Xu, Xiaomeng, Desai, Aditya J, Dong, Maoqing, Mobbs, Jesse I, Toufaily, Chirine, Furness, Sebastian G B, Christopoulos, Arthur, Belousoff, Matthew J, Wootten, Denise, Sexton, Patrick M, Miller, Laurence J
Published in PLoS biology (31.07.2024)
Published in PLoS biology (31.07.2024)
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Journal Article
Discovery of an archetypal protein transport system in bacterial outer membranes
Selkrig, Joel, Mosbahi, Khedidja, Webb, Chaille T, Belousoff, Matthew J, Perry, Andrew J, Wells, Timothy J, Morris, Faye, Leyton, Denisse L, Totsika, Makrina, Phan, Minh-Duy, Celik, Nermin, Kelly, Michelle, Oates, Clare, Hartland, Elizabeth L, Robins-Browne, Roy M, Ramarathinam, Sri Harsha, Purcell, Anthony W, Schembri, Mark A, Strugnell, Richard A, Henderson, Ian R, Walker, Daniel, Lithgow, Trevor
Published in Nature structural & molecular biology (01.05.2012)
Published in Nature structural & molecular biology (01.05.2012)
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