Identification of the Clinical Candidate (R)‑(1-(4-Fluorophenyl)-6-((1-methyl‑1H‑pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro‑1H‑pyrazolo[3,4‑g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist
Hunt, Hazel J, Belanoff, Joseph K, Walters, Iain, Gourdet, Benoit, Thomas, Jennifer, Barton, Naomi, Unitt, John, Phillips, Timothy, Swift, Denise, Eaton, Emily
Published in Journal of medicinal chemistry (27.04.2017)
Published in Journal of medicinal chemistry (27.04.2017)
Get full text
Journal Article
Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator
Zalachoras, Ioannis, Houtman, René, Atucha, Erika, Devos, Rene, Tijssen, Ans M. I., Hu, Pu, Lockey, Peter M., Datson, Nicole A., Belanoff, Joseph K., Lucassen, Paul J., Joëls, Marian, de Kloet, E. Ronald, Roozendaal, Benno, Hunt, Hazel, Meijer, Onno C.
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (07.05.2013)
Get full text
Journal Article
Effects of selective and non-selective glucocorticoid receptor II antagonists on rapid-onset diabetes in young rats
Beaudry, Jacqueline L, Dunford, Emily C, Teich, Trevor, Zaharieva, Dessi, Hunt, Hazel, Belanoff, Joseph K, Riddell, Michael C
Published in PloS one (18.03.2014)
Published in PloS one (18.03.2014)
Get full text
Journal Article
Acute effects of neonatal dexamethasone treatment on proliferation and astrocyte immunoreactivity in hippocampus and corpus callosum: Towards a rescue strategy
Claessens, Sanne E.F, Belanoff, Joseph K, Kanatsou, Sofia, Lucassen, Paul J, Champagne, Danielle L, Ronald de Kloet, E
Published in Brain research (30.10.2012)
Published in Brain research (30.10.2012)
Get full text
Journal Article
Rapid reversal of psychotic depression using mifepristone
Belanoff, J K, Flores, B H, Kalezhan, M, Sund, B, Schatzberg, A F
Published in Journal of clinical psychopharmacology (01.10.2001)
Published in Journal of clinical psychopharmacology (01.10.2001)
Get more information
Journal Article
New selective glucocorticoid receptor modulators reverse amyloid-β peptide-induced hippocampus toxicity
Pineau, Fanny, Canet, Geoffrey, Desrumaux, Catherine, Hunt, Hazel, Chevallier, Nathalie, Ollivier, Matthias, Belanoff, Joseph K, Givalois, Laurent
Published in Neurobiology of aging (01.09.2016)
Published in Neurobiology of aging (01.09.2016)
Get full text
Journal Article
Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals
Vendruscolo, Leandro F, Estey, David, Goodell, Vivian, Macshane, Lauren G, Logrip, Marian L, Schlosburg, Joel E, McGinn, M Adrienne, Zamora-Martinez, Eva R, Belanoff, Joseph K, Hunt, Hazel J, Sanna, Pietro P, George, Olivier, Koob, George F, Edwards, Scott, Mason, Barbara J
Published in The Journal of clinical investigation (01.08.2015)
Published in The Journal of clinical investigation (01.08.2015)
Get full text
Journal Article
Glucocorticoid receptors signaling impairment potentiates amyloid-β oligomers-induced pathology in an acute model of Alzheimer's disease
Canet, Geoffrey, Pineau, Fanny, Zussy, Charleine, Hernandez, Célia, Hunt, Hazel, Chevallier, Nathalie, Perrier, Véronique, Torrent, Joan, Belanoff, Joseph K, Meijer, Onno C, Desrumaux, Catherine, Givalois, Laurent
Published in The FASEB journal (01.01.2020)
Published in The FASEB journal (01.01.2020)
Get more information
Journal Article
Resetting the Stress System with a Mifepristone Challenge
Dalm, Sergiu, Karssen, Adriaan M., Meijer, Onno C., Belanoff, Joseph K., de Kloet, E. Ronald
Published in Cellular and molecular neurobiology (01.05.2019)
Published in Cellular and molecular neurobiology (01.05.2019)
Get full text
Journal Article
Selective Glucocorticoid Receptor Modulation Prevents and Reverses Nonalcoholic Fatty Liver Disease in Male Mice
Koorneef, Lisa L, van den Heuvel, José K, Kroon, Jan, Boon, Mariëtte R, 't Hoen, Peter A C, Hettne, Kristina M, van de Velde, Nienke M, Kolenbrander, Kelsey B, Streefland, Trea C M, Mol, Isabel M, Sips, Hetty C M, Kielbasa, Szymon M, Mei, Hailiang, Belanoff, Joseph K, Pereira, Alberto M, Oosterveer, Maaike H, Hunt, Hazel, Rensen, Patrick C N, Meijer, Onno C
Published in Endocrinology (Philadelphia) (01.12.2018)
Published in Endocrinology (Philadelphia) (01.12.2018)
Get full text
Journal Article
A Mixed Glucocorticoid/Mineralocorticoid Selective Modulator With Dominant Antagonism in the Male Rat Brain
Atucha, Erika, Zalachoras, Ioannis, van den Heuvel, José K, van Weert, Lisa T. C. M, Melchers, Diana, Mol, Isabel M, Belanoff, Joseph K, Houtman, René, Hunt, Hazel, Roozendaal, Benno, Meijer, Onno C
Published in Endocrinology (Philadelphia) (01.11.2015)
Published in Endocrinology (Philadelphia) (01.11.2015)
Get full text
Journal Article
1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile
Hunt, Hazel J., Belanoff, Joseph K., Golding, Emily, Gourdet, Benoit, Phillips, Timothy, Swift, Denise, Thomas, Jennifer, Unitt, John F., Walters, Iain
Published in Bioorganic & medicinal chemistry letters (15.12.2015)
Published in Bioorganic & medicinal chemistry letters (15.12.2015)
Get full text
Journal Article
Glucocorticoid antagonism limits adiposity rebound and glucose intolerance in young male rats following the cessation of daily exercise and caloric restriction
Teich, Trevor, Dunford, Emily C, Porras, Deanna P, Pivovarov, Jacklyn A, Beaudry, Jacqueline L, Hunt, Hazel, Belanoff, Joseph K, Riddell, Michael C
Published in American journal of physiology: endocrinology and metabolism (01.07.2016)
Published in American journal of physiology: endocrinology and metabolism (01.07.2016)
Get full text
Journal Article