Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design
Rut, Wioletta, Lv, Zongyang, Zmudzinski, Mikolaj, Patchett, Stephanie, Nayak, Digant, Snipas, Scott J, El Oualid, Farid, Huang, Tony T, Bekes, Miklos, Drag, Marcin, Olsen, Shaun K
Published in Science advances (16.10.2020)
Published in Science advances (16.10.2020)
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Journal Article
Structure and Substrate Recognition of the Escherichia coli DNA Adenine Methyltransferase
Horton, John R., Liebert, Kirsten, Bekes, Miklos, Jeltsch, Albert, Cheng, Xiaodong
Published in Journal of molecular biology (28.04.2006)
Published in Journal of molecular biology (28.04.2006)
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Synthetic substrates for measuring activity of autophagy proteases-autophagins (Atg4): Autophagins (Atg4)
Shu, Chih-Wen, Drag, Marcin, Bekes, Miklos, Zhai, Dayong, Salvesen, Guy S., Reed, John C.
Published in Autophagy (01.10.2010)
Published in Autophagy (01.10.2010)
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Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes)
Drag, Marcin, Mikolajczyk, Jowita, Bekes, Miklos, Reyes-Turcu, Francisca E, Ellman, Jonathan A, Wilkinson, Keith D, Salvesen, Guy S
Published in Biochemical journal (01.11.2008)
Published in Biochemical journal (01.11.2008)
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Journal Article
PROTAC targeted protein degraders: the past is prologue
Békés, Miklós, Langley, David R., Crews, Craig M.
Published in Nature reviews. Drug discovery (01.03.2022)
Published in Nature reviews. Drug discovery (01.03.2022)
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Journal Article
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Rut, Wioletta, Zmudzinski, Mikolaj, Snipas, Scott J, Bekes, Miklos, Huang, Tony T, Drag, Marcin
Published in Chemical Science (21.06.2020)
Published in Chemical Science (21.06.2020)
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Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes† †Electronic supplementary information (ESI) available: DUBs substrate specificity, DUB labelling in cell lysates, pull-down experiment, structures of natural and unnatural amino acids and characterization of all compounds (PDF). See DOI: 10.1039/d0sc01347a
Rut, Wioletta, Zmudzinski, Mikolaj, Snipas, Scott J., Bekes, Miklos, Huang, Tony T., Drag, Marcin
Published in Chemical science (Cambridge) (27.05.2020)
Published in Chemical science (Cambridge) (27.05.2020)
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Journal Article
Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease
Békés, Miklós, van der Heden van Noort, Gerbrand J., Ekkebus, Reggy, Ovaa, Huib, Huang, Tony T., Lima, Christopher D.
Published in Molecular cell (19.05.2016)
Published in Molecular cell (19.05.2016)
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Journal Article
Deubiquitinases as a Signaling Target of Oxidative Stress
Cotto-Rios, Xiomaris M., Békés, Miklós, Chapman, Jessica, Ueberheide, Beatrix, Huang, Tony T.
Published in Cell reports (Cambridge) (27.12.2012)
Published in Cell reports (Cambridge) (27.12.2012)
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Journal Article
Abstract PR09: KRAS-targeted PROTAC degraders are broadly efficacious against KRAS-dependent tumor models
Smith, Kathryn, Lopez-Arroyo, Andrea, Berk, Jason, Hegan, Peter, Nower, Peter, Tice, Samantha, Moutran, Aurelie, Pizzano, Jennifer, Dowtin, Amanda, Bookbinder, Mark, Bortolon, Elizabeth, Cadelina, Greg, Karim, Fazlul, Digianantonio, Katie, Bekes, Miklos, Medina, Jesus
Published in Molecular cancer research (01.05.2023)
Published in Molecular cancer research (01.05.2023)
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Oral Estrogen Receptor PROTAC Vepdegestrant (ARV-471) Is Highly Efficacious as Monotherapy and in Combination with CDK4/6 or PI3K/mTOR Pathway Inhibitors in Preclinical ER+ Breast Cancer Models
Gough, Sheryl M, Flanagan, John J, Teh, Jessica, Andreoli, Monica, Rousseau, Emma, Pannone, Melissa, Bookbinder, Mark, Willard, Ryan, Davenport, Kim, Bortolon, Elizabeth, Cadelina, Gregory, Gordon, Debbie, Pizzano, Jennifer, Macaluso, Jennifer, Soto, Leofal, Corradi, John, Digianantonio, Katherine, Drulyte, Ieva, Morgan, Alicia, Quinn, Connor, Békés, Miklós, Ferraro, Caterina, Chen, Xin, Wang, Gan, Dong, Hanqing, Wang, Jing, Langley, David R, Houston, John, Gedrich, Richard, Taylor, Ian C
Published in Clinical cancer research (15.08.2024)
Published in Clinical cancer research (15.08.2024)
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Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules
Hickey, Christopher M., Digianantonio, Katherine M., Zimmermann, Kurt, Harbin, Alicia, Quinn, Connor, Patel, Avani, Gareiss, Peter, Chapman, Amanda, Tiberi, Bernadette, Dobrodziej, Jennifer, Corradi, John, Cacace, Angela M., Langley, David R., Békés, Miklós
Published in Nature structural & molecular biology (01.02.2024)
Published in Nature structural & molecular biology (01.02.2024)
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Journal Article
Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs
Mikolajczyk, Jowita, Drag, Marcin, Békés, Miklós, Cao, John T, Ronai, Ze'ev, Salvesen, Guy S
Published in The Journal of biological chemistry (07.09.2007)
Published in The Journal of biological chemistry (07.09.2007)
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Journal Article
The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity
Suisse, Annabelle, Békés, Miklós, Huang, Tony T., Treisman, Jessica E.
Published in Fly (Austin, Tex.) (03.04.2018)
Published in Fly (Austin, Tex.) (03.04.2018)
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Journal Article
Protection from Isopeptidase-Mediated Deconjugation Regulates Paralog-Selective Sumoylation of RanGAP1
Zhu, Shanshan, Goeres, Jacqueline, Sixt, Katherine M., Békés, Miklós, Zhang, Xiang-Dong, Salvesen, Guy S., Matunis, Michael J.
Published in Molecular cell (13.03.2009)
Published in Molecular cell (13.03.2009)
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Journal Article
DUB-Resistant Ubiquitin to Survey Ubiquitination Switches in Mammalian Cells
Békés, Miklós, Okamoto, Keiji, Crist, Sarah B., Jones, Mathew J., Chapman, Jessica R., Brasher, Bradley B., Melandri, Francesco D., Ueberheide, Beatrix M., Lazzerini Denchi, Eros, Huang, Tony T.
Published in Cell reports (Cambridge) (14.11.2013)
Published in Cell reports (Cambridge) (14.11.2013)
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