An Xpb Mouse Model for Combined Xeroderma Pigmentosum and Cockayne Syndrome Reveals Progeroid Features upon Further Attenuation of DNA Repair
Andressoo, Jaan-Olle, Weeda, Geert, de Wit, Jan, Mitchell, James R., Beems, Rudolf B., van Steeg, Harry, van der Horst, Gijsbertus T. J., Hoeijmakers, Jan H.
Published in Molecular and Cellular Biology (01.03.2009)
Published in Molecular and Cellular Biology (01.03.2009)
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Increased Sensitivity to UV Radiation in Mice with a p53 Point Mutation at Ser389
Bruins, Wendy, Zwart, Edwin, Attardi, Laura D., Iwakuma, Tomoo, Hoogervorst, Esther M., Beems, Rudolf B., Miranda, Barbara, van Oostrom, Conny T. M., van den Berg, Jolanda, van den Aardweg, Gerard J., Lozano, Guillermina, van Steeg, Harry, Jacks, Tyler, de Vries, Annemieke
Published in Molecular and Cellular Biology (01.10.2004)
Published in Molecular and Cellular Biology (01.10.2004)
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Finding transcriptomics biomarkers for in vivo identification of (non-)genotoxic carcinogens using wild-type and Xpa/p53 mutant mouse models
Jonker, Martijs J., Bruning, Oskar, van Iterson, Maarten, Schaap, Mirjam M., van der Hoeven, Tessa V., Vrieling, Harry, Beems, Rudolf B., de Vries, Annemieke, van Steeg, Harry, Breit, Timo M., Luijten, Mirjam
Published in Carcinogenesis (New York) (01.10.2009)
Published in Carcinogenesis (New York) (01.10.2009)
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Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development
WIJNHOVEN, Susan W. P, ZWART, Edwin, VAN STEEG, Harry, DE VRIES, Annemieke, SPEKSNIJDER, Ewoud N, BEEMS, Rudolf B, OLIVE, Kenneth P, TUVESON, David A, JONKERS, Jos, SCHAAP, Mirjam M, VAN DEN BERG, Jolanda, JACKS, Tyler
Published in Cancer research (Chicago, Ill.) (15.09.2005)
Published in Cancer research (Chicago, Ill.) (15.09.2005)
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Journal Article
MPHASYS: a mouse phenotype analysis system
Calder, R Brent, Beems, Rudolf B, van Steeg, Harry, Mian, I Saira, Lohman, Paul H M, Vijg, Jan
Published in BMC bioinformatics (06.06.2007)
Published in BMC bioinformatics (06.06.2007)
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Phenacetin acts as a weak genotoxic compound preferentially in the kidney of DNA repair deficient Xpa mice
Luijten, Mirjam, Speksnijder, Ewoud N, van Alphen, Niels, Westerman, Anja, Heisterkamp, Siem H, van Benthem, Jan, van Kreijl, Coen F, Beems, Rudolf B, van Steeg, Harry
Published in Mutation research (11.04.2006)
Published in Mutation research (11.04.2006)
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Broad segmental progeroid changes in short-lived Ercc1(-/Δ7) mice
Dollé, Martijn E T, Kuiper, Raoul V, Roodbergen, Marianne, Robinson, Joke, de Vlugt, Sisca, Wijnhoven, Susan W P, Beems, Rudolf B, de la Fonteyne, Liset, de With, Piet, van der Pluijm, Ingrid, Niedernhofer, Laura J, Hasty, Paul, Vijg, Jan, Hoeijmakers, Jan H J, van Steeg, Harry
Published in Pathobiology of aging & age related diseases (2011)
Published in Pathobiology of aging & age related diseases (2011)
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Mouse Models for Xeroderma Pigmentosum Group A and Group C Show Divergent Cancer Phenotypes
MELIS, Joost P. M, WIJNHOVEN, Susan W. P, VAN STEEG, Harry, BEEMS, Rudolf B, ROODBERGEN, Marianne, VAN DEN BERG, Jolanda, MOON, Hojin, FRIEDBERG, Errol, VAN DER HORST, Gijsbertus T. J, HOEIJMAKERS, Jan H. J, VIJG, Jan
Published in Cancer research (Chicago, Ill.) (01.03.2008)
Published in Cancer research (Chicago, Ill.) (01.03.2008)
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Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction
Wijnhoven, Susan W P, Beems, Rudolf B, Roodbergen, Marianne, van den Berg, Jolanda, Lohman, Paul H M, Diderich, Karin, van der Horst, Gijsbertus T J, Vijg, Jan, Hoeijmakers, Jan H J, van Steeg, Harry
Published in DNA repair (21.11.2005)
Published in DNA repair (21.11.2005)
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Journal Article
Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage
WIJNHOVEN, Susan W. P, SPEKSNIJDER, Ewoud N, VAN STEEG, Harry, JONKERS, Jos, DE VRIES, Annemieke, XIAOLING LIU, ZWART, Edwin, VANOOSTROM, Conny Th. M, BEEMS, Rudolf B, HOOGERVORST, Esther M, SCHAAP, Mirjam M, ATTARDI, Laura D, JACKS, Tyler
Published in Cancer research (Chicago, Ill.) (15.05.2007)
Published in Cancer research (Chicago, Ill.) (15.05.2007)
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Defective Transcription-Coupled Repair in Cockayne Syndrome B Mice Is Associated with Skin Cancer Predisposition
van der Horst, Gijsbertus T.J, van Steeg, Harry, Berg, Rob J.W, van Gool, Alain J, de Wit, Jan, Weeda, Geert, Morreau, Hans, Beems, Rudolf B, van Kreijl, Coen F, de Gruijl, Frank R, Bootsma, Dirk, Hoeijmakers, Jan H.J
Published in Cell (02.05.1997)
Published in Cell (02.05.1997)
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Journal Article
DNA repair-deficient Xpa/p53 knockout mice are sensitive to the non-genotoxic carcinogen cyclosporine A: escape of initiated cells from immunosurveillance?
van Kesteren, Petra C.E., Beems, Rudolf B., Luijten, Mirjam, Robinson, Joke, de Vries, Annemieke, van Steeg, Harry
Published in Carcinogenesis (New York) (01.03.2009)
Published in Carcinogenesis (New York) (01.03.2009)
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Lack of p53 Ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-induced bladder tumors but not ionizing radiation-induced lymphomas
Hoogervorst, Esther M, Bruins, Wendy, Zwart, Edwin, van Oostrom, Conny Th M, van den Aardweg, Gerard J, Beems, Rudolf B, van den Berg, Jolanda, Jacks, Tyler, van Steeg, Harry, de Vries, Annemieke
Published in Cancer research (Chicago, Ill.) (01.05.2005)
Published in Cancer research (Chicago, Ill.) (01.05.2005)
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Journal Article
p53 Heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice
HOOGERVORST, Esther M, VAN OOSTROM, Conny Th. M, BEEMS, Rudolf B, VAN BENTHEM, Jan, GIELIS, Siska, VERMEULEN, Jolanda P, WESTER, Piet W, VOS, Joseph G, DE VRIES, Annemieke, VAN STEEG, Harry
Published in Cancer research (Chicago, Ill.) (01.08.2004)
Published in Cancer research (Chicago, Ill.) (01.08.2004)
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Modulation of mammary tumor development in Tg.NK (MMTV/c- neu) mice by dietary fatty acids and life stage-specific exposure to phytoestrogens
Luijten, Mirjam, Verhoef, Aart, Dormans, Jan A.M.A., Beems, Rudolf B., Cremers, Hans W.J.M., Nagelkerke, Nico J.D., Adlercreutz, Herman, Peñalvo, José L., Piersma, Aldert H.
Published in Reproductive toxicology (Elmsford, N.Y.) (01.04.2007)
Published in Reproductive toxicology (Elmsford, N.Y.) (01.04.2007)
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Suppression of UV carcinogenesis by difluoromethylornithine in nucleotide excision repair-deficient Xpa knockout mice
REBEL, Heggert, VAN STEEG, Harry, BEEMS, Rudolf B, SCHOUTEN, Ron, DE GRUIJL, Frank R, TERLETH, Carrol
Published in Cancer research (Chicago, Ill.) (01.03.2002)
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Published in Cancer research (Chicago, Ill.) (01.03.2002)
Journal Article
2-AAF-induced tumor development in nucleotide excision repair-deficient mice is associated with a defect in global genome repair but not with transcription coupled repair
Hoogervorst, Esther M., Oostrom, Conny Th. M. van, Beems, Rudolf B., Benthem, Jan van, Berg, Jolanda van den, Kreijl, Coen F. van, Vos, Joseph G., Vries, Annemieke de, van Steeg, Harry
Published in DNA repair (02.01.2005)
Published in DNA repair (02.01.2005)
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Journal Article
Combined oral benzo[a]pyrene and inhalatory ozone exposure have no effect on lung tumor development in DNA repair-deficient Xpa mice
Hoogervorst, Esther M., de Vries, Annemieke, Beems, Rudolf B., van Oostrom, Conny Th.M., Wester, Piet W., Vos, Joseph G., Bruins, Wendy, Roodbergen, Marianne, Cassee, Flemming R., Vijg, Jan, van Schooten, Frederik-Jan, van Steeg, Harry
Published in Carcinogenesis (New York) (01.03.2003)
Published in Carcinogenesis (New York) (01.03.2003)
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Journal Article
Accelerated aging pathology in ad libitum fed XpdTTD mice is accompanied by features suggestive of caloric restriction
WIJNHOVEN, Susan W. P, BEEMS, Rudolf B, ROODBERGEN, Marianne, VAN DEN BERG, Jolanda, LOHMAN, Paul H. M, DIDERICH, Karin, VAN DER HORST, Gijsbertus T. J, VIJG, Jan, HOEIJMAKERS, Jan H. J, VAN STEEG, Harry
Published in DNA repair (01.11.2005)
Published in DNA repair (01.11.2005)
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