Discovery and Structure−Activity Relationship of (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT2C Receptor Agonist for the Treatment of Obesity
Smith, Brian M, Smith, Jeffrey M, Tsai, James H, Schultz, Jeffrey A, Gilson, Charles A, Estrada, Scott A, Chen, Rita R, Park, Douglas M, Prieto, Emily B, Gallardo, Charlemagne S, Sengupta, Dipanjan, Dosa, Peter I, Covel, Jon A, Ren, Albert, Webb, Robert R, Beeley, Nigel R. A, Martin, Michael, Morgan, Michael, Espitia, Stephen, Saldana, Hazel R, Bjenning, Christina, Whelan, Kevin T, Grottick, Andrew J, Menzaghi, Frederique, Thomsen, William J
Published in Journal of medicinal chemistry (24.01.2008)
Published in Journal of medicinal chemistry (24.01.2008)
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Discovery of 1-[3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin) and Related 5-Hydroxytryptamine2A Inverse Agonists for the Treatment of Insomnia
Teegarden, Bradley R, Li, Hongmei, Jayakumar, Honnappa, Strah-Pleynet, Sonja, Dosa, Peter I, Selaya, Susan D, Kato, Naomi, Elwell, Katie H, Davidson, Jarrod, Cheng, Karen, Saldana, Hazel, Frazer, John M, Whelan, Kevin, Foster, Jonathan, Espitia, Stephan, Webb, Robert R, Beeley, Nigel R. A, Thomsen, William, Morairty, Stephen R, Kilduff, Thomas S, Al-Shamma, Hussien A
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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CHEMOSENSORY RECEPTOR LIGAND-BASED THERAPIES
BEELEY NIGEL R. A, FINEMAN MARK S, BROWN MARTIN R, JONES CHRISTOPHER R. G, BARON ALAIN D
Year of Publication 21.03.2014
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Year of Publication 21.03.2014
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Discovery of 1-[3-(4-Bromo-2-methyl-2 H -pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin) and Related 5-Hydroxytryptamine 2A Inverse Agonists for the Treatment of Insomnia
Teegarden, Bradley R., Li, Hongmei, Jayakumar, Honnappa, Strah-Pleynet, Sonja, Dosa, Peter I., Selaya, Susan D., Kato, Naomi, Elwell, Katie H., Davidson, Jarrod, Cheng, Karen, Saldana, Hazel, Frazer, John M., Whelan, Kevin, Foster, Jonathan, Espitia, Stephan, Webb, Robert R., Beeley, Nigel R. A., Thomsen, William, Morairty, Stephen R., Kilduff, Thomas S., Al-Shamma, Hussien A.
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity
SMITH, Brian M, SMITH, Jeffrey M, DIPANJAN SENGUPTA, THOMSEN, William J, SALDANA, Hazel R, WHELAN, Kevin T, MENZAGHI, Frederique, WEBB, Robert R, BEELEY, Nigel R. A, TSAI, James H, SCHULTZ, Jeffrey A, GILSON, Charles A, ESTRADA, Scott A, CHEN, Rita R, PARK, Douglas M, PRIETO, Emily B, GALLARDO, Charlemagne S
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
Published in Bioorganic & medicinal chemistry letters (01.03.2005)
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A GENERAL-SYNTHESIS OF N-SUBSTITUTED ISOTHIAZOL-3(2H)-ONES
BEELEY, NRA, HARWOOD, LM, HEDGER, PC
Published in Journal of the Chemical Society, Perkin Transactions 1 (1994)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1994)
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Discovery and Structure-Activity Relationship of (1R)-8-Chloro-2,3,4,5-tetrahydro-l-methyl-1H-3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT2C Receptor Agonist for the Treatment of Obesity
SMITH, Brian M, SMITH, Jeffrey M, SENGUPTA, Dipanjan, DOSA, Peter I, COVEL, Jon A, REN, Albert, WEBB, Robert R, BEELEY, Nigel R. A, MARTIN, Michael, MORGAN, Michael, ESPITIA, Stephen, SALDANA, Hazel R, TSAI, James H, BJENNING, Christina, WHELAN, Kevin T, GROTTICK, Andrew J, MENZAGHI, Frederique, THOMSEN, William J, SCHULTZ, Jeffrey A, GILSON, Charles A, ESTRADA, Scott A, CHEN, Rita R, PARK, Douglas M, PRIETO, Emily B, GALLARDO, Charlemagne S
Published in Journal of medicinal chemistry (2008)
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Published in Journal of medicinal chemistry (2008)
Journal Article
Discovery and Structure−Activity Relationship of (1 R )-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1 H -3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT 2C Receptor Agonist for the Treatment of Obesity
Smith, Brian M., Smith, Jeffrey M., Tsai, James H., Schultz, Jeffrey A., Gilson, Charles A., Estrada, Scott A., Chen, Rita R., Park, Douglas M., Prieto, Emily B., Gallardo, Charlemagne S., Sengupta, Dipanjan, Dosa, Peter I., Covel, Jon A., Ren, Albert, Webb, Robert R., Beeley, Nigel R. A., Martin, Michael, Morgan, Michael, Espitia, Stephen, Saldana, Hazel R., Bjenning, Christina, Whelan, Kevin T., Grottick, Andrew J., Menzaghi, Frederique, Thomsen, William J.
Published in Journal of medicinal chemistry (01.01.2008)
Published in Journal of medicinal chemistry (01.01.2008)
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Synthesis of C- and N-functionalised derivatives of 1,4,7-triazacyclononane-1,4,7-triyltriacetic acid (NOTA), 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetrayltetra-acetic acid (DOTA), and diethylenenetriaminepenta-acetic acid (DTPA): bifunctional complexing agents for the derivatisation of antibodies
Cox, Jonathan P. L., Craig, Andrew S., Helps, Ian M., Jankowski, Karl J., Parker, David, Eaton, Michael A. W., Millican, Andrew T., Millar, Kenneth, Beeley, Nigel R. A., Boyce, Byron A.
Published in Journal of the Chemical Society, Perkin Transactions 1 (1990)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1990)
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