A Phase 1, randomized, double-blind, placebo-controlled, single- and multiple-dose escalation study to evaluate the safety and pharmacokinetics/pharmacodynamics of PF-06835375, a C-X-C chemokine receptor type 5 directed antibody, in patients with systemic lupus erythematosus or rheumatoid arthritis
Cohen, Stanley, Beebe, Jean S, Chindalore, Vishala, Guan, Shunjie, Hassan-Zahraee, Mina, Saxena, Madhurima, Xi, Li, Hyde, Craig, Koride, Sarita, Levin, Robert, Lubaczewski, Shannon, Salganik, Mikhail, Sloan, Abigail, Stevens, Erin, Peeva, Elena, Vincent, Michael S, Martin, David A, Chu, Myron
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Published in Arthritis research & therapy (06.06.2024)
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Discovering in vivo cytokine-eQTL interactions from a lupus clinical trial
Davenport, Emma E, Amariuta, Tiffany, Gutierrez-Arcelus, Maria, Slowikowski, Kamil, Westra, Harm-Jan, Luo, Yang, Shen, Ciyue, Rao, Deepak A, Zhang, Ying, Pearson, Stephen, von Schack, David, Beebe, Jean S, Bing, Nan, John, Sally, Vincent, Michael S, Zhang, Baohong, Raychaudhuri, Soumya
Published in Genome Biology (19.10.2018)
Published in Genome Biology (19.10.2018)
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Exploratory pharmacodynamics and efficacy of PF-06817024 in a Phase 1 study of patients with chronic rhinosinusitis and atopic dermatitis
Danto, Spencer I, Tsamandouras, Nikolaos, Reddy, Padma, Gilbert, Steven A, Mancuso, Jessica Y, Page, Karen, Beebe, Jean S, Peeva, Elena, Vincent, Michael S
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Combination Therapy Enhances the Inhibition of Tumor Growth with the Fully Human Anti–Type 1 Insulin-Like Growth Factor Receptor Monoclonal Antibody CP-751,871
COHEN, Bruce D, BAKER, Deborah A, MOYER, James D, SODERSTROM, Catherine, TKALCEVIC, George, ROSSI, Ann Marie, MILLER, Penny E, TENGOWSKI, Mark W, WANG, Faye, GUALBERTO, Antonio, BEEBE, Jean S
Published in Clinical cancer research (01.03.2005)
Published in Clinical cancer research (01.03.2005)
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Anti-IL21 receptor monoclonal antibody (ATR-107): Safety, pharmacokinetics, and pharmacodynamic evaluation in healthy volunteers: a phase I, first-in-human study
Hua, Fei, Comer, Gail M, Stockert, Lori, Jin, Bo, Nowak, John, Pleasic-Williams, Susan, Wunderlich, David, Cheng, John, Beebe, Jean S
Published in Journal of clinical pharmacology (01.01.2014)
Published in Journal of clinical pharmacology (01.01.2014)
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Efficacy and Safety of Oral Janus Kinase 1 Inhibitor Abrocitinib for Patients With Atopic Dermatitis: A Phase 2 Randomized Clinical Trial
Gooderham, Melinda J, Forman, Seth B, Bissonnette, Robert, Beebe, Jean S, Zhang, Weidong, Banfield, Chris, Zhu, Linda, Papacharalambous, Jocelyne, Vincent, Michael S, Peeva, Elena
Published in JAMA dermatology (Chicago, Ill.) (01.12.2019)
Published in JAMA dermatology (Chicago, Ill.) (01.12.2019)
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Efficacy and Safety of PF‐06651600 (Ritlecitinib), a Novel JAK3/TEC Inhibitor, in Patients With Moderate‐to‐Severe Rheumatoid Arthritis and an Inadequate Response to Methotrexate
Robinson, Michael F., Damjanov, Nemanja, Stamenkovic, Bojana, Radunovic, Goran, Kivitz, Alan, Cox, Lori, Manukyan, Zorayr, Banfield, Christopher, Saunders, Michael, Chandra, Deepa, Vincent, Michael S., Mancuso, Jessica, Peeva, Elena, Beebe, Jean S.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.10.2020)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.10.2020)
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Efficacy and safety of topical brepocitinib for the treatment of mild‐to‐moderate atopic dermatitis: a phase IIb, randomized, double‐blind, vehicle‐controlled, dose‐ranging and parallel‐group study
Landis, Megan N., Arya, Mark, Smith, Stacy, Draelos, Zoe, Usdan, Lisa, Tarabar, Sanela, Pradhan, Vivek, Aggarwal, Sudeepta, Banfield, Christopher, Peeva, Elena, Vincent, Michael S., Sikirica, Vanja, Xenakis, Jason, Beebe, Jean S.
Published in British journal of dermatology (1951) (01.12.2022)
Published in British journal of dermatology (1951) (01.12.2022)
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Efficacy and Safety of the TYK2/JAK1 Inhibitor Brepocitinib for Active Psoriatic Arthritis: A Phase IIb Randomized Controlled Trial
Mease, Philip, Helliwell, Philip, Silwinska‐Stanczyk, Paula, Miakisz, Malgorzata, Ostor, Andrew, Peeva, Elena, Vincent, Michael S., Sun, Qiankun, Sikirica, Vanja, Winnette, Randall, Qiu, Ruolun, Li, Gang, Feng, Gang, Beebe, Jean S., Martin, David A.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.08.2023)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.08.2023)
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Efficacy and safety of topical brepocitinib cream for mild-to-moderate chronic plaque psoriasis: a phase IIb randomized double-blind vehicle-controlled parallel-group study
Landis, Megan N, Smith, Stacy R, Berstein, Gabriel, Fetterly, Gerald, Ghosh, Pranab, Feng, Gang, Pradhan, Vivek, Aggarwal, Sudeepta, Banfield, Christopher, Peeva, Elena, Vincent, Michael S, Beebe, Jean S, Tarabar, Sanela
Published in British journal of dermatology (1951) (07.07.2023)
Published in British journal of dermatology (1951) (07.07.2023)
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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PF‐06817024 in Healthy Participants, Participants with Chronic Rhinosinusitis with Nasal Polyps, and Participants with Atopic Dermatitis: A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled Study
Danto, Spencer I., Tsamandouras, Nikolaos, Reddy, Padmalatha, Gilbert, Steven, Mancuso, Jessica, Page, Karen, Peeva, Elena, Vincent, Michael S., Beebe, Jean S.
Published in Journal of clinical pharmacology (01.05.2024)
Published in Journal of clinical pharmacology (01.05.2024)
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Design and SAR of thienopyrimidine and thienopyridine inhibitors of VEGFR-2 kinase activity
Munchhof, Michael J., Beebe, Jean S., Casavant, Jeffery M., Cooper, Beth A., Doty, Jonathan L., Higdon, R.Carla, Hillerman, Stephen M., Soderstrom, Catherine I., Knauth, Elisabeth A., Marx, Matthew A., Rossi, Ann Marie K., Sobolov, Susan B., Sun, Jianmin
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
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Evidence for the Epidermal Growth Factor Receptor As a Target for Lung Cancer Prevention
Lonardo, Fulvio, Dragnev, Konstantin H, Freemantle, Sarah J, Ma, Yan, Memoli, Natalie, Sekula, David, Knauth, Elisabeth A, Beebe, Jean S, Dmitrovsky, Ethan
Published in Clinical cancer research (01.01.2002)
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Published in Clinical cancer research (01.01.2002)
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Increased Serum Enzyme Levels Associated with Kupffer Cell Reduction with No Signs of Hepatic or Skeletal Muscle Injury
Radi, Zaher A, Koza-Taylor, Petra H, Bell, Rosonald R, Obert, Leslie A, Runnels, Herbert A, Beebe, Jean S, Lawton, Michael P, Sadis, Seth
Published in The American journal of pathology (01.07.2011)
Published in The American journal of pathology (01.07.2011)
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Microarray analysis uncovers retinoid targets in human bronchial epithelial cells
YAN MA, KOZA-TAYLOR, Petra H, DIMATTIA, Debra A, HAMES, Lynn, HAONING FU, DRAGNEV, Konstantin H, TURI, Tom, BEEBE, Jean S, FREEMANTLE, Sarah J, DMITROVSKY, Ethan
Published in Oncogene (31.07.2003)
Published in Oncogene (31.07.2003)
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Patient-Reported Symptoms and Disease Impacts in Adults With Moderate-to-Severe Atopic Dermatitis: Results From a Phase 2b Study With Abrocitinib
Simpson, Eric L, Wollenberg, Andreas, Bissonnette, Robert, Silverberg, Jonathan I, Papacharalambous, Jocelyne, Zhu, Linda, Zhang, Weidong, Beebe, Jean S, Vincent, Michael, Peeva, Elena, Bushmakin, Andrew G, Cappelleri, Joseph C, Chen, Linda, Sikirica, Vanja, Xenakis, Jason
Published in Dermatitis (01.10.2021)
Published in Dermatitis (01.10.2021)
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A Phase 1 Study to Assess Mass Balance and Absolute Bioavailability of Zimlovisertib in Healthy Male Participants Using a 14C‐Microtracer Approach
Singh, Ravi Shankar P., Dowty, Martin E., Salganik, Mikhail, Brodfuehrer, Joanne I., Walker, Gregory S., Sharma, Raman, Beebe, Jean S., Danto, Spencer I.
Published in Clinical pharmacology in drug development (01.07.2022)
Published in Clinical pharmacology in drug development (01.07.2022)
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A Phase 1 Study to Assess Mass Balance and Absolute Bioavailability of Zimlovisertib in Healthy Male Participants Using a 14 C-Microtracer Approach
Singh, Ravi Shankar P, Dowty, Martin E, Salganik, Mikhail, Brodfuehrer, Joanne I, Walker, Gregory S, Sharma, Raman, Beebe, Jean S, Danto, Spencer I
Published in Clinical pharmacology in drug development (01.07.2022)
Published in Clinical pharmacology in drug development (01.07.2022)
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Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy
Beebe, Jean S, Jani, Jitesh P, Knauth, Elisabeth, Goodwin, Peter, Higdon, Carla, Rossi, Ann Marie, Emerson, Erling, Finkelstein, Martin, Floyd, Eugenia, Harriman, Shawn, Atherton, Jim, Hillerman, Steve, Soderstrom, Cathy, Kou, Kou, Gant, Tom, Noe, Mark C, Foster, Barb, Rastinejad, Farzan, Marx, Matthew A, Schaeffer, Tracey, Whalen, Pamela M, Roberts, W Gregory
Published in Cancer research (Chicago, Ill.) (01.11.2003)
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Published in Cancer research (Chicago, Ill.) (01.11.2003)
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Discovery and synthesis of novel 4-aminopyrrolopyrimidine Tie-2 kinase inhibitors for the treatment of solid tumors
Arcari, Joel T., Beebe, Jean S., Berliner, Martin A., Bernardo, Vincent, Boehm, Merin, Borzillo, Gary V., Clark, Tracey, Cohen, Bruce D., Connell, Richard D., Frost, Heather N., Gordon, Deborah A., Hungerford, William M., Kakar, Shefali M., Kanter, Aaron, Keene, Nandell F., Knauth, Elizabeth A., LaGreca, Susan D., Lu, Yong, Martinez-Alsina, Louis, Marx, Matthew A., Morris, Joel, Patel, Nandini C., Savage, Doug, Soderstrom, Cathy I., Thompson, Carl, Tkalcevic, George, Tom, Norma J., Vajdos, Felix F., Valentine, James J., Vincent, Patrick W., Wessel, Matthew D., Chen, Jinshan M.
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
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