Epichaperome inhibition targets TP53-mutant AML and AML stem/progenitor cells
Carter, Bing Z., Mak, Po Yee, Muftuoglu, Muharrem, Tao, Wenjing, Ke, Baozhen, Pei, Jingqi, Bedoy, Andrea D., Ostermann, Lauren B., Nishida, Yuki, Isgandarova, Sevinj, Sobieski, Mary, Nguyen, Nghi, Powell, Reid T., Martinez-Moczygemba, Margarita, Stephan, Clifford, Basyal, Mahesh, Pemmaraju, Naveen, Boettcher, Steffen, Ebert, Benjamin L., Shpall, Elizabeth J., Wallner, Barbara, Morgan, Robert A., Karras, Georgios I., Moll, Ute M., Andreeff, Michael
Published in Blood (21.09.2023)
Published in Blood (21.09.2023)
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Journal Article
Novel Hypomethylating Agent Ntx-301 Exhibits Anti-Leukemia Activity in Venetoclax-Resistant and TP53-Mutant AML
Carter, Bing Z., Mak, Po Yee, Ke, Baozhen, Bedoy, Andrea, Boettcher, Steffen, Ostermann, Lauren B., Shpall, Elizabeth J., Andreeff, Michael
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Single-Cell Proteomic Analysis Reveals Menin Inhibition-Induced Proteomic Alterations in AML Patients Treated with Revumenib
Muftuoglu, Muharrem, Li, Li, Basyal, Mahesh, Ayoub, Edward, Lv, Jiangxing, Bedoy, Andrea, Patsilevas, Tallie, Bidikian, Aram, Issa, Ghayas C., Andreeff, Michael
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Selective Targeting of TP53-Y220C Mutant AML By PC14586 Results in TP53 Wild-Type Conformation and Synergistical Apoptosis Induction By Concomitant Inhibition of Xpo-1, MDM2, or Bcl-2
Carter, Bing Z., Mak, Po Yee, Ke, Baozhen, Nishida, Yuki, Boettcher, Steffen, Bedoy, Andrea, Ostermann, Lauren B., DiNardo, Courtney D., Puzio-Kuter, Anna, Levine, Arnold, Andreeff, Michael
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Single-Cell Genomics and Proteomics Reveals Venetoclax-Resistant Monocytic Differentiation of TP53 LOH Clones in TP53 Mutant AML
Ayoub, Edward, Li, Li, Muftuoglu, Muharrem, Nishida, Yuki, Mohanty, Vakul, Leighton, Jake S, Patsilevas, Tallie, Basyal, Mahesh, Bedoy, Andrea, Haferlach, Torsten, Takahashi, Koichi, Chen, Ken, Navin, Nicholas, Issa, Ghayas C., Andreeff, Michael
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article