Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets
Brownell, James E, Bedford, Lynn, Lowe, James, Dick, Lawrence R, Mayer, R. John
Published in Nature reviews. Drug discovery (01.01.2011)
Published in Nature reviews. Drug discovery (01.01.2011)
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Journal Article
Assembly, structure, and function of the 26S proteasome
Bedford, Lynn, Paine, Simon, Sheppard, Paul W, Mayer, R. John, Roelofs, Jeroen
Published in Trends in cell biology (01.07.2010)
Published in Trends in cell biology (01.07.2010)
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Journal Article
Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway
Kageyama, Shun, Sou, Yu-shin, Uemura, Takefumi, Kametaka, Satoshi, Saito, Tetsuya, Ishimura, Ryosuke, Kouno, Tsuguka, Bedford, Lynn, Mayer, R. John, Lee, Myung-Shik, Yamamoto, Masayuki, Waguri, Satoshi, Tanaka, Keiji, Komatsu, Masaaki
Published in The Journal of biological chemistry (05.09.2014)
Published in The Journal of biological chemistry (05.09.2014)
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Journal Article
Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies
Bedford, Lynn, Hay, David, Devoy, Anny, Paine, Simon, Powe, Des G, Seth, Rashmi, Gray, Trevor, Topham, Ian, Fone, Kevin, Rezvani, Nooshin, Mee, Maureen, Soane, Tim, Layfield, Robert, Sheppard, Paul W, Ebendal, Ted, Usoskin, Dmitry, Lowe, James, Mayer, R. John
Published in The Journal of neuroscience (13.08.2008)
Published in The Journal of neuroscience (13.08.2008)
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Journal Article
Monoamine oxidase-A promotes protective autophagy in human SH-SY5Y neuroblastoma cells through Bcl-2 phosphorylation
Ugun-Klusek, Aslihan, Theodosi, Theodosis S, Fitzgerald, Julia C, Burté, Florence, Ufer, Christoph, Boocock, David J, Yu-Wai-Man, Patrick, Bedford, Lynn, Billett, E Ellen
Published in Redox biology (01.01.2019)
Published in Redox biology (01.01.2019)
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Journal Article
Alcohol-related brain damage in humans
Erdozain, Amaia M, Morentin, Benito, Bedford, Lynn, King, Emma, Tooth, David, Brewer, Charlotte, Wayne, Declan, Johnson, Laura, Gerdes, Henry K, Wigmore, Peter, Callado, Luis F, Carter, Wayne G
Published in PloS one (03.04.2014)
Published in PloS one (03.04.2014)
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Journal Article
Pale body-like inclusion formation and neurodegeneration following depletion of 26S proteasomes in mouse brain neurones are independent of α-synuclein
Paine, Simon M L, Anderson, Glenn, Bedford, Karen, Lawler, Karen, Mayer, R John, Lowe, James, Bedford, Lynn
Published in PloS one (2013)
Published in PloS one (2013)
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Journal Article
Heterozygosity for the proteasomal Psmc1 ATPase is insufficient to cause neuropathology in mouse brain, but causes cell cycle defects in mouse embryonic fibroblasts
Rezvani, Nooshin, Elkharaz, Jamal, Lawler, Karen, Mee, Maureen, Mayer, R. John, Bedford, Lynn
Published in Neuroscience letters (19.07.2012)
Published in Neuroscience letters (19.07.2012)
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Journal Article
Id4 is required for the correct timing of neural differentiation
Bedford, Lynn, Walker, Robert, Kondo, Toru, van Crüchten, Ingeborg, King, Emerson R., Sablitzky, Fred
Published in Developmental biology (15.04.2005)
Published in Developmental biology (15.04.2005)
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Journal Article
The UPS and autophagy in chronic neurodegenerative disease: Six of one and half a dozen of the other-Or not?
Bedford, Lynn, Paine, Simon, Rezvani, Nooshin, Mee, Maureen, Lowe, James, Mayer, R. John
Published in Autophagy (16.02.2009)
Published in Autophagy (16.02.2009)
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Journal Article
Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons
Geiszler, Philippine C, Ugun-Klusek, Aslihan, Lawler, Karen, Pardon, Marie-Christine, Yuchun, Ding, Bai, Li, Daykin, Clare A, Auer, Dorothee P, Bedford, Lynn
Published in Scientific reports (19.03.2018)
Published in Scientific reports (19.03.2018)
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Journal Article
Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway
Ugun-Klusek, Aslihan, Tatham, Michael H, Elkharaz, Jamal, Constantin-Teodosiu, Dumitru, Lawler, Karen, Mohamed, Hala, Paine, Simon M L, Anderson, Glen, John Mayer, R, Lowe, James, Ellen Billett, E, Bedford, Lynn
Published in Cell death & disease (05.01.2017)
Published in Cell death & disease (05.01.2017)
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Journal Article
Implications for oxidative stress and astrocytes following 26S proteasomal depletion in mouse forebrain neurones
Elkharaz, Jamal, Ugun-Klusek, Aslihan, Constantin-Teodosiu, Dumitru, Lawler, Karen, Mayer, R John, Billett, Ellen, Lowe, James, Bedford, Lynn
Published in Biochimica et biophysica acta (01.12.2013)
Published in Biochimica et biophysica acta (01.12.2013)
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Journal Article
CRMP2 hyperphosphorylation is characteristic of Alzheimer's disease and not a feature common to other neurodegenerative diseases
Williamson, Ritchie, van Aalten, Lidy, Mann, David M A, Platt, Bettina, Plattner, Florian, Bedford, Lynn, Mayer, John, Howlett, David, Usardi, Alessia, Sutherland, Calum, Cole, Adam R
Published in Journal of Alzheimer's disease (01.01.2011)
Published in Journal of Alzheimer's disease (01.01.2011)
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Journal Article
Pale Body-Like Inclusion Formation and Neurodegeneration following Depletion of 26S Proteasomes in Mouse Brain Neurones are Independent of [alpha]-Synuclein
Paine, Simon M. L, Anderson, Glenn, Bedford, Karen, Lawler, Karen, Mayer, R. John, Lowe, James, Bedford, Lynn
Published in PloS one (30.01.2013)
Published in PloS one (30.01.2013)
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Journal Article
Diverse polyubiquitin chains accumulate following 26S proteasomal dysfunction in mammalian neurones
Bedford, Lynn, Layfield, Robert, Mayer, R. John, Peng, Junmin, Xu, Ping
Published in Neuroscience letters (10.03.2011)
Published in Neuroscience letters (10.03.2011)
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Journal Article